Objective To study the clinical effects of the intensive insulin therapy on diabetes with acute obstructive suppurative cholangitis in elderly patients.Methods Sixty-four patients aged over 70 were divided into two groups:group A(maintenance of blood glucose at a level between 4.4 and 6.1lmmol/L)and group B(maintenance of blood glucose at a level between 10.0 and 11.1mmol/L).Insulin was infused by micro-injection pump.The changes of APACHEII score postoperative complications,average length of stay in hospital and prognosis were observed.Results The average APACHEII score of group A was significantly decreased after 3rd day postoperation(P＜0.01).The average length of stay in hospital of group A was significantly shorter than that of group B(P＜0.05).The postoperative complications of group A were significantly decreased(P＜0.05).Conclusion Intensive insulin therapy contributes to the outcome of the elderly patients with acute obstructive suppurative cholangitis.