Objective To investigate the effect of interventional therapy for acute severe pancreatitis.Methods A total of 70 patients with acute severe pancreatitis were randomly divided into Control(common medication) and Interventional Therapy groups(common medication plus interventional therapy) with 35 cases in each.The curative effect was compared between the two groups.Results Compared with the Control Group,the patients in the Interventional Therapy Group had a significantly lower mortality [25.7%(9/35) vs 5.7%(2/35);?2=5.285,P=0.022],lower incidence of ARDS [37.1%(13/35) vs 14.3%(5/35);?2=4.786,P=0.029],decreased incidence of pancreatic encephalopathy[34.3%(12/35) vs 11.4%(4/35);?2=5.185,P=0.023],shorter recovery time of serum amylase[(7.6?2.1) d vs(3.4?1.5) d;t=-9.628,P=0.000],and shorter hospital stay[(34.0?6.4) d vs.(23.5?8.9) d;t=-5.667,P=0.000].In the Interventional Group,the symptoms and signs disappeared at(10.0?2.4)d after the treatment,which was significantly earlier than that in the Control Group(18.0?2.6)d(t=-13.376,P=0.000).Conclusions Interventional therapy can effectively control acute severe pancreatitis and shorten the course of the disease.

ObjectiveTo study the risk factors and pathogenic characteristics of ventilator associated pneumonia(YAP). MethodsRisk factors of VAP,pathogens and drug resistance in 118 patients in ICU were analyzed retrospectively. ResultsThe incidence of VAP was 44.9％, and age, the mechanical ventilation time, state of consciousness,tracheotomy,the antibiotic combination are risk factors of incidence of VAP. 53cases of VAP(68.2％ )were infected by Gram negative bacilli,25.9％ were by Gram positive cocci,and 5.9％ were by fungi. Drug resistance was observed obviously. ConclusionThe occurrence of VAP was related with multiple factors. The gram negative bacteria are the major pathogens of VAP, and the rate of drug resistance was high. The occurrence of VAP could severely affect patients' prognosis.