Objective To observe the effects of trunk and ankle dorsiflexion training on the motor function of the hemiplegics affected lower limb. Methods 36 cases with hemiplegia were divided into two groups: treatment group (n=22) and control group (n=14). The treatment group accepted trunk and ankle dorsiflexion training, while the control group not. They were assessed with Ueda Assessment 2 months after treatment. Results 22 cases (100%) in the treatment group were grade 8 or higher, while 7 cases (50%) in the control group. Conclusion Trunk and ankle dorsiflexion training are important for the recovery of motor function in the hemiplegics.

A 60-years-old(85 kg,178 cm) coronary arterial disease patient having had acute myocardial infarction for several times received liver transplantation successfully.He had a previous episode of acute myocardial infarction associated with entire obstruction of right coronary 6 years ago,and was inserted a bracket then.One year ago the patient got chest pain again,and was diagnosed as inferior wall myocardial infarction.Then he received expectant treatment in internal medical department for several days.A 774HF75 PAC catheter(Edwards Lifescience,USA) was inserted into an internal jugular vein,and cardiac output,right ventricular end diastolic volume index,right ventricular ejection fraction,stroke volume index,system vascular resistance,pulmonary vascular resistance,left ventricular-stroke work index and right ventricular-stroke work index were calculated.During the operation,cardiovascular medications such as dopamine,norepinephrine,dobutamine were infused and adjusted by steps carefully.Electrolytes and acid-base balance were maintained normal.With these hemodynamic parameters,BGA and systemic management,the anesthesia was managed safely and successfully.

Objective:To explore the feasibility of guiding the volume management during orthotopic liver transplantation by right ventricular end-diastolic volume index(RVEDVI).Methods:Thirty-two patients who accepted OLT were studied during operation.A modified pulmonary artery catheter equipped with a fast response thermistor(774HF75)was used to determine RVEDVI,EF,CCI,CVP,MPAP,PAOP and SVI.The above-mentioned hemodynamic measures were taken in 9 phases:T0,before induction of anesthesia;T1,before operation;T2,pre-anhepatic phase;T3,30 minutes after PV occlusion;T4,10 minutes after graft reperfusion;T5,30 minutes after graft reperfusion;T6,60 minutes after graft reperfusion;T7,120 minutes after graft reperfusion;and T8,at the end of surgery.The linear regression analyses of SVI and CVP,SVI and PAOP,SVI and RVEDVI in each phase were calculated,and the best measure of representing the volume of the OLT patient was selected.Results:The variation of the RVEF value was(42.04?9.40)%.Linear regression analyses showed a significant correlation between RVEDVI and stroke volume index(SVI) in each phase(P

Objective To investigate the effect of ulinastatin on postoperative cardiac troponin I ( cTnI) in patients underwent carotid endarterectomy ( CEA) under general anesthesia. Methods Forty patients with severe symptomatic carotid artery stenosis underwent unilateral CEA under general anesthesia from January 2011 to March 2012 were divided into either a ulinastatin group or a control group according to a random number table ( n=20 in each group) . Patients in the ulinastatin group received 500 000 U of ulinastatin via veins before induction of anesthesia. The patients in the control group were given the same amount of isotonic saline. The serum concentrations of cardiac troponin I ( cTnI ) were detected before surgery and at day 1,2,and 3 after procedure. Myocardial injury was defined as the cTnI peak concentration>0. 04μg/L . Results The levels of serum cTnI before procedure and at day 1,2,and 3 after procedure in the ulinastatin group were median (M) 0. 00 (0. 00-0. 03) μg/L,0. 07 (0. 00-1. 45) μg/L,0. 01 (0. 00-1. 21)μg/L,and 0. 05 (0. 00-0. 89)μg/L,respectively;those in the control group were 0. 00 (0. 00-0. 01)μg/L,0. 00 (0. 00-1. 42)μg/L,0. 00 (0. 00-1. 39)μg/L,and 0. 00 (0. 00-1. 24)μg/L, respectively. At day 1 after procedure,6 patients ( 30%) in the control group and 11 ( 55%) in the ulinastatin group occurred myocardial injury. There was no significant difference between the two groups (P<0. 05). In all the patients with the increased cTnI levels,the peak cTnI occurred at the first day after procedure,however,they did not reach the level ( >1. 5μg/L) of indicating patients occurring myocardial infarction. Conclusion Ulinastatin may not decrease the postoperative serum cTnI levels in CEA patients under general anesthesia. For whether to the CEA patients have myocardial protective effect,more samples are needed to be confirmed.

Objective: To observe the efficacy of controlled hypotention with nicardipine and influences on endocrine system. Method: Twenty adult patient, ASA grade Ⅰ-Ⅱ, scheduled for bone tumour operation, were selected. After the operation begining, Nicar of 0.01-0.02mg/kg was given at central venous bolus, was infused at 1-4?g?kg?min~(-1). Result: Hemodynamics was very stable during controlled hypotension, regulating frequency of Niear dosage was 1.5?0.7 time/h, reaching time of aim blood pressure was 47?31s, BP recovery time from discontinuating Nicar intusion to pre-hypotention level was 40?11min and no hypertention rebound occurred after discontinuation of Nicar. Fifteen min following controlled hypotension, plasma catecholamine (CA) level increased (P0.05). During mass bleeding and subsequent malignant hypotension, serious arrhythmia and oliguria did not occur. Conclusion: Controlled hypotension with Niear is rapid, stable and easy without hypertension rebound. The influences of Nicar on plasma CA are only very obvious. Nicar has considerable protective effects on heart and kidney during mass bleeding.

Objective To determine perioperative changes of tumor necrosis factor alpha (TNF ?),superoxide dismutase(SOD),lipid peroxides(LPO) and creatine kinase MB (CK MB) in patients undergoing cardiopulmonary bypass (CPB) Methods Thirteen patients undergoing heart valves surgery were studied Blood samples were taken from artery and coronary sinus for measurement of plasma TNF ? and LPO concentrations, and plasma SOD and CK MB activities prior to CPB, 5min,30min after aorta declamping, at the end of operation, 6h and 18h after surgery respectively Blood gas analysis was done at various intervals and alveolar arterial oxygen gradient (P A a DO 2) was calculated The net myocardial release of TNF ? (coronary sinus plasma level minus arterial level) was recorded Results Arterial and coronary sinus TNF? levels increased significantly following aortic declamping as compared with those before CPB and were kept at the higher level till the end of operation (P

Objective To assess the influences of cardiopulmonary bypass (CPB) on energy matabolism and the effect of nicardipine pretreatment. Methods Sixteen patients with valvlar heart disease undergoing valve replacement were chosen and randomly allocated into control group (group C, n=8) and nicardipine pretreatment group (group N,n=8). In group N, nicardipine 0.5?g?kg -1?min -1 was continuously infused after induction of anesthesia and terminated before CPB. The total dose given was 0.5mg?kg -1. If the total dose was not reached before CPB, the rest dose was given immediately after the beginning of CPB. Arterial and coronary sinus blood samples were taken immediately before CPB,at 5,30min after the aortic declamping , the end of operation, 6 and 18h after operation.Blood lactate and glucose concentrations were measured. Blood gas was checked simultaneously. Then myocardial lactate extraction rate (LER) and myocardial glucose extraction rate(GER) and myocardial oxygen extraction index(MOEI) were calculated. Results In group C GER and LER decreased signficantly after aortic declamping as compared with those before CPB (P

Objective To investigate the feasibility of inducing controlled hypotension (CH) with nicardipine and low dose esmolol and its influence on blood catecholamine, blood beta 2-microlobulin (?2-mG) and tissue aerobic metabolism. Methods Thirty patients undergoing elective surgery for bone tumor were randomly divided into 3 groups: control group (C, n = 10); nicardipine group (N, n = 10) and nicardipine + esmolol group (N + E, n= 10). Controlled hypotension (CH) was started 15 min after incision. In group N nicardipine was infused at 2.5?g?kg-1?min-1 initially and in group N + E nicardipine (2.5?g?kg-1?min-1 ) and esmolol (12. 5?g?kg-1?min-1) were infused initially. When MAP was reduced to 60-70mm Hg nicardipine infusion rate was adjusted to maintain MAP at this level in both groups. In control group no CH was induced. The patients were premedicated with pethidine 25-50mg and scopolamine 0.3?g im. Anesthesia was induced with fentanyl 3?g?kg-1, propofol 1.2-2.5mg?kg-1 and vecuronium 0. 12mg?kg-1 iv and maintained with isoflurane inhalation (end-tidal concentration 1.0%-2.0%) and intermittent iv boluses of vecuronium . Radial artery was cannulated for continuous BP monitoring and internal jugular vein was cannulated for CVP monitoring. ECG , SpO2 and end-tidal CO2 concentration were continuously monitored . Blood samples were taken before CH (T0) , when MAP was reduced to 60-70mm Hg (T1), 30 min after CH had been maintained for 30min(T2 ), at the end of CH (T3) and at the end of operation (T4 ) for determination of concentrations of catecholamine ,?2-mG , lactate and Hb. Results The demographic data including age, body weight and height were comparable among the three groups. There was no significant difference in preoperative Hb and ALT, AST, Cr andBUN levels. There was also no significant difference in the duration of CH between group N and group N + E . In group C and N norepinephrine (NE) level gradually increased during CH whereas in group N + E NE level increased only slightly during CH as compared with the baseline value (T0) , and was maintained at this low level.?2-mG level was not significantly elevated during CH but lactate level increased significantly during CH in all three groups . There was no significant difference in urine output during CH among the three groups. Conclusion Hypotension with nicardipine does not result in tissue anaerobic metabolism and renal damage. Its combination with low dose esmolol has stress-inhibiting effect.

Objective To study the influence of pulmonary ischemia-reperfusion (I/R) induced by cardio-pulmonary bypass (CPB) on pulmonary function and the preventive effect of nicardipine.Methods Sixteen patients scheduled for cardiac valve replacement were randomly divided into two groups : control group ( n = 8) and nicardipine group ( n = 8) . In nicardipine group nicardipine 0.02 mg kg-1 was given at the beginning of CPB; while in control group normal saline was given instead of nicardipine. All patients were operated upon under TIVA with large doses of fentanyl. Swan-Ganz catheter was placed via internal jugular vein after induction of anesthesia. Mean pulmonary arterial pressure (MPAP), pulmonary vascular resistance index (PVRI) and lung compliance were measured and calculated before CPB (T0 ), 5min after declamping of vena cava (T1 ), at tennination of CPB (T2) and at the end of operation (T3 ). At the same time points arterial and mixed venous blood samples were taken for determination of TNF-a, SOD and LPO concentrations and polymorphonuclear leukocyte (PMN) count, intrapulmonary PMN trapping (PMNa-PMNv) and blood gases and calculation of PaO2/FiO2 , P(A-2,)O2 difference and Qs/Qt. The vena cava cross-clamping time was defined as pulmonary ischemia time. Results (1) In control group MPAP, PVRI, PaO2/FiO2 and Qs/Qt were significantly deteriorating after vena cava declamping (T1-T3) as compared with the baseline valves (T0) (P