1.Effect of drynaria total flavonoid on TGF-β1 and BMP-2 secretion in the process of rats bone mesenchymal stem cells osteogenic differentiation
Xiaochun SHU ; Danhua ZHU ; Hongyun LU ; Tianjiao PANG ; Liao SUN ; Lihong YE ; Jing SHEN ; Danhong XIE
Chinese Journal of Endocrinology and Metabolism 2010;26(11):990-992
The rats were assigned to blank control group, classical induction group, and drynaria total flavonoid group. Whole bone marrow culture method was applied to isolate and purify rats bone mesenchymal stem cells (BMSCs). Akaline phosphatase activity, calcium nodes, TGF-β1 and BMP-2 secretion in the process of bone mesenchymal stem cells osteogenic differentiation were detected. The results showed that compared to the blank group and classical group, drynaria total flavonoid promoted osteogenic differentiation accompanied with increased TGF-β1 and BMP-2 secretion (all P<0. 05). Drynaria total flavonoid may promote osteogenic differentiation of BMSCs via upregulating TGF-β1 and BMP-2 expressions, and play an active role in the treatment of osteoporosis.
2.Pathogenesis of Chronic Obstructive Pulmonary Disease and Modulating Effect of Traditional Chinese Medicine: A Review
Jiyu ZOU ; Tianjiao WANG ; Ningzi ZANG ; Yongming LIU ; Lijian PANG ; Linlin WANG ; Xiaodong LYU
Chinese Journal of Experimental Traditional Medical Formulae 2025;31(1):287-298
Chronic obstructive pulmonary disease (COPD), as a chronic respiratory disease that can be prevented and intervened but cannot be completely cured, has increasing incidence and mortality rates year by year, often complicated by one or more comorbidities. However, there is currently no specific treatment available. Therefore, the healthcare issues related to COPD are urgent and prominent. Traditional Chinese medicine (TCM) delays the progression of COPD through multiple mechanisms, pathways, and targets. As a result, exploring the pathogenesis of COPD and identifying TCM treatment approaches and effective prescriptions are key issues that urgently need to be addressed in clinical practice. In TCM, COPD is categorized into syndromes such as "cough", "asthma", and "lung distension". It is believed that the deficiency in the origin runs through the entire disease. When external pathogens invade, Qi becomes disordered, and phlegm and blood stasis begin to accumulate, leading to an excess condition in the manifestation. Modern medicine research on the pathogenesis of COPD mainly involves aspects such as inflammatory response, oxidative stress, autophagy imbalance, and aging. Studies have found that Chinese medicine monomers, single herbs, and compound prescriptions can improve COPD by inhibiting inflammation, reducing oxidative damage, correcting autophagy, and delaying aging. However, there is no study that intuitively organizes the various pathogenesis mechanisms of COPD and their interrelationships. At the same time, research on the therapeutic effects of TCM on COPD primarily focuses on exploring a single mechanism or pathway, without integrating multiple mechanisms, pathways, and targets. Additionally, there are very few studies that summarize the corresponding relationships between the various pathogenesis mechanisms of COPD and the regulatory effects and signaling pathways of Chinese medicine. This study, for the first time, combines the latest literature in China and abroad to explain the various pathogenesis mechanisms of COPD and their interrelationships using a combination of graphs, text, and tables. It also outlines the signaling pathways, targets, and mechanisms of Chinese medicine monomers, single herbs, and compound prescriptions in regulating COPD, in order to provide new ideas and strategies for the in-depth research and systematic treatment of COPD with TCM.
3.Utilization and quality assessment of digestive endoscopy in China: results from 5-year consecutive nationwide surveys.
Lei XIN ; Ye GAO ; Zhiyuan CHENG ; Tianjiao WANG ; Han LIN ; Yanan PANG ; Chang SUN ; Zengjun FU ; Zhaoshen LI ; Xudong MA ; Luowei WANG
Chinese Medical Journal 2022;135(16):2003-2010
BACKGROUND:
Worldwide, the volume and availability of digestive endoscopy have undergone dramatic development in recent years, with increasing attention on quality assurance. We investigated the utilization and quality of digestive endoscopy in China from 2015 to 2019 and developed a quantitative quality evaluation tool for medical institutions.
METHODS:
We invited all tertiary/secondary hospitals in Chinese mainland to participate in the survey annually. The questionnaires included the personnel, annual volume, and quality indicators of endoscopy. An endoscopy quality index (EQI) was developed based on recorded quality indicators using principal component analysis to determine the relative weight.
RESULTS:
From 2015 to 2019, 806, 1412, 2644, 2468, and 2541 hospitals were respectively enrolled in this study. The average annual volume of endoscopy increased from 12,445 to 16,206 (1.30-fold) and from 2938 to 4255 (1.45-fold) in tertiary and secondary hospitals, respectively. The most obvious growth was observed in diagnostic colonoscopy (1.44-fold for all hospitals after standardization). The proportion of early cancer among all esophageal and gastric cancers during diagnostic esophagogastroduodenoscopy increased from 12.3% (55,210/448,861) to 17.7% (85,429/482,647) and from 11.4% (69,411/608,866) to 16.9% (107,192/634,235), respectively. The adenoma detection rate of diagnostic colonoscopy increased from 14.9% (2,118,123/14,215,592) to 19.3% (3,943,203/20,431,104). The EQI model included 12 quality indicators, incorporating 64.9% (7.792/12) of the total variance into one comprehensive index. According to the EQI measurements, the quality of endoscopy was higher in tertiary hospitals and hospitals in developed areas with higher volume or more endoscopists than that in other hospitals.
CONCLUSIONS
Digestive endoscopy in China has developed considerably in recent years in terms of both volume and quality. The EQI is a promising tool to quantify the quality of endoscopy at different hospitals.
Humans
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Colonoscopy/methods*
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Endoscopy, Gastrointestinal
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Endoscopy, Digestive System/methods*
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Surveys and Questionnaires
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Adenoma
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China