Objective To study the feasibility and safety of transradial approach for coronary interventions Methods Coronary intervention was tried to be performed via transradial approach in 116 patients with coronary heart disease (96 males, 20 females, mean age 57 44?9 40 years) Results Transradial puncture failed in 5 cases and coronary interventions were performed via transfemoral approach instead Coronary intervention failed in 2 cases although transradial puncture succeeded Both transradial puncture and coronary intervention succeeded in the rest 109 cases One hundred and thirty five narrowed coronary arteries were dilated (69 LAD, 26 LCX, 39 RCA, 1 venous graft) One hundred and forty eight coronary lesions, including 15 type A, 106 type B and 27 type C lesions were treated One hundred and ten stents were implanted in 105 coronary arteries of 98 patients Rotablator was performed in one case and intracoronary ultrasound detected for another Changing guiding catheter was necessary for 25 cases during the procedure Transfusion was needed due to puncture site bleeding in one case Big hematoma was found in two cases Perforation of a branch of brachial artery happened in another case No surgery repair needed Conclusion Coronary intervention via transradial approach was feasible, but the radial artery puncture was somewhat difficult, and guiding catheter support is poor to some extent One must be cautious about vascular damages near the puncture site