No abstract available.
Gout* ; Humans ; Thiazoles ; Febuxostat

The synthesis, structure elucidation and bio-activity of certain new 2-subtituted thiazole derivatives were reported. The newly prepared compounds were screened for their in vitro antibacterial and antifungal activities. The result revealed that almost compounds were active against fungi, 5 compounds were active against gram-positive bacteria. Meanwhile, 3 compounds had a remarkable both antibacterial and antifungal activities.
Thiazoles ; Analogs & derivatives

The objective of this study was to evaluate the effect of color measuring instrument by measuring the color of dental composite resins. Nine shade light cured composite resin disks were prepared (diameter : 15 mm, thickness : 4 mm). CIE L*a*b* color scale of each disk was measured with 3 different types of spectrophotometer [MiniScan XE plus (Model 4000S, Hunter Lab, USA), CM-3500d (Minolta, Japan) and Specbos 2100 Miniature VIS Reflection spectrometer (Serial No: 319416, JETI Technishe VIS Instrumentic GmbH, Germany)]. Miniscan XE Plus and CM-3500d using identical measuring geometry with different size of viewing aperture. But Specbos 2100 using different measuring geometry. Within the limitation of this study, there were color difference (DeltaE*) from 2.4 to 7.8 between Miniscan XE Plus and CM-3500d, but L*, a*, b* values showed the high correlation. However, there were great color difference (DeltaE*) in the extent of about 20 between instruments with the different measuring geometry. Therefore, color scale measured by color measuring instrument should be used as a relative value rather than an absolute value in the field of dentistry.
Dentistry ; Light ; Pyridines ; Thiazoles

Glucometers offer a simple and rapid method of self-monitoring blood glucose levels and are widely used by diabetic clinics and patients. The accuracy of a glucometer depends on the meter's performance as well as the user's proficiency level. It is also important to regularly use and calibrate the meter it in order to maintain consistent readings. Since glucometers are considered clinically accurate if the result is within +/- 15 mg/dL of the results of the manufacturer's measurement procedure at glucose concentrations < 75 mg/dL, and within +/- 20% at glucose concentrations > or = 75 mg/dL. It is crucial to compare the meter's result with a lab test result at least once a year in order to maintain the reliability of the meter. Diabetes educators should have thorough knowledge of each meter and be aware of its accuracy so that he or she can properly and accurately educate diabetic patients.
Blood Glucose ; Glucose ; Humans ; Pyridines ; Reading ; Thiazoles

As a technically demanding skill, microsurgery is taught in the lab, in the form of a course of variable length (depending on the centre). Microsurgical training courses usually use a mixture of non-living and live animal simulation models. In the literature, a plethora of microsurgical training models have been described, ranging from low to high fidelity models. Given the high costs associated with live animal models, cheaper alternatives are coming into vogue. In this paper we describe the use of the chicken aorta as a simple and cost effective low fidelity microsurgical simulation model for training.
Animal Experimentation ; Animals ; Aorta ; Chickens ; Microsurgery ; Models, Animal ; Pyridines ; Thiazoles

OBJECTIVES: The purpose of this study was to measure the power density of light curing units transmitted through resin inlays fabricated with direct composite (Filtek Z350, Filtek Supreme XT) and indirect composite (Sinfony). MATERIALS AND METHODS: A3 shade of Z350, A3B and A3E shades of Supreme XT, and A3, E3, and T1 shades of Sinfony were used to fabricate the resin inlays in 1.5 mm thickness. The power density of a halogen light curing unit (Optilux 360) and an LED light curing unit (Elipar S10) through the fabricated resin inlays was measured with a hand held dental radiometer (Cure Rite). To investigate the effect of each composite layer consisting the resin inlays on light transmission, resin specimens of each shade were fabricated in 0.5 mm thickness and power density was measured through the resin specimens. RESULTS: The power density through the resin inlays was lowest with the Z350 A3, followed by Supreme XT A3B and A3E. The power density was highest with Sinfony A3, E3, and T1 (p < 0.05). The power density through 0.5 mm thick resin specimens was lowest with dentin shades, Sinfony A3, Z350 A3, Supreme XT A3B, followed by enamel shades, Supreme XT A3E and Sinfony E3. The power density was highest with translucent shade, Sinfony T1 (p < 0.05). CONCLUSIONS: Using indirect lab composites with dentin, enamel, and translucent shades rather than direct composites with one or two shades could be advantageous in transmitting curing lights through resin inlays.
Composite Resins ; Dental Enamel ; Dentin ; Hand ; Inlays ; Light ; Pyridines ; Thiazoles

We attempted to determine whether energy density would influence calorie intake via cognitive cues, as reflected by satiety. This experiment was designed using two different energy density levels of Kimbab: normal Kimbab (1.6 kcal/g) vs low-density Kimbab (1.0 kcal/g). 26 female college students participated in this study. The subjects ate Kimbab in the lab once a week for 2 weeks. Each week at noon, they were served 24 units of either normal or low-density Kimbab, and we determined the units, grams, and calories of the real & cognitive intake of Kimbab, and also analyzed the satiety rate after eating Kimbab. Our results demonstrated that the real calorie intake from the low-density Kimbab was significantly lower than that of the normal Kimbab (290.3 kcal vs 474.4 kcal, p<0.001), but we noted no significant differences in the units and grams of real and cognitive intake between the normal and low-density Kimbab. However, despite consuming 39% lower caloric intake, the subjects reported similar levels of satiety rates with the two different density levels of Kimbab, as they did not perceive themselves to have eaten more normal Kimbab than low-density Kimbab. Thus, this study provides evidence that the energy density of food is a crucial determinant of caloric intake, and supports the notion that the consumption of low energy-dense foods may result in a reduction of caloric intake without altering satiety.
Cues ; Eating ; Energy Intake ; Female ; Humans ; Pyridines ; Thiazoles

PURPOSE: The purpose of this study was to evaluate the influence of porcelain re-firing on the formation of surface bubble and on the change in shade of metal-ceramic crown exposed to artificial saliva. MATERIALS AND METHODS: Thirty disk-shaped specimens were made in 10 mm diameter with 0.5 mm metal core thickness and 1 mm ceramic thickness. A spectroradiometer was used to determine the CIE Lab coordinates. The number and size of surface bubble were observed with a stereomicroscope. After the exposure to artificial saliva for 7 days, re-firing was performed at glazing temperature. After re-firing, the CIE Lab were calculated, and the number and size of surface bubble were observed again. The change in shade was expressed with DeltaE. Statistical analysis was done with paired t-test for the change in the number of surface bubble and student t-test for the change in the size of surface bubble (alpha= 0.05). RESULTS: Shade difference was calculated 2.14 DeltaE units. The mean number of surface bubble was 1.33 +/- 1.49 before re-firing, 3.27 +/- 2.90 after re-firing. After re-firing, the number of surface bubble was significantly increased (P<.05). The mean size of surface bubble was 81.97 +/- 32.03 microm before re-firing, 142.94 +/- 47.40 microm after re-firing. After re-firing, the size of surface bubble was significantly increased (P<.05). CONCLUSION: Shade change after re-firing was perceptible (DeltaE < 2.0) and clinically acceptable (DeltaE < 3.7). The number and size of surface bubble was significantly increased after re-firing. Further investigation to decrease the surface bubble on the extra oral repair of metal-ceramic crown, will be needed in future study.
Ceramics ; Crowns ; Dental Porcelain ; Humans ; Pyridines ; Saliva, Artificial ; Thiazoles

OBJECTIVE: To compare the urate-lowering efficacy and the safety of febuxostat, allopurinol and placebo in Korean patients with gout for 4 weeks. METHODS: Subjects (n=182) with gout were randomized to febuxostat (40, 80, 120 mg), allopurinol 300 mg, or placebo group. The primary end point was the proportion of subjects whose serum urate concentration fell to less than 6.0 mg/dL after the 4-week treatment. RESULTS: The primary end point was reached at 25.7%, 80.0% and 83.3% of patients receiving 40, 80 and 120 mg of febuxostat, respectively, 58.3% of those receiving 300 mg of allopurinol and none of the placebo (p<0.001: each febuxostat dose or allopurinol group versus placebo group, p=0.0484 and p=0.0196: febuxostat 80 and 120 mg compared with allopurinol, respectively). The number and proportion of subjects who developed adverse events (AEs) were 13 subjects (37%), 14 (39%) and 18 (50%) in the febuxostat of 40, 80 and 120 mg group, respectively, 21 (57%) in the allopurinol 300 mg group and 17 (46%) in the placebo group. No statistically significant differences in the incidence rates of adverse events were observed between the groups. There was no significant difference in gout flare-up incidence. CONCLUSION: Febuxostat, 80 mg or 120 mg, was more effective than allopurinol (300 mg) or placebo, when lowering the serum urate. The safety of febuxostat and allopurinol was comparable.
Allopurinol ; Gout ; Humans ; Incidence ; Thiazoles ; Uric Acid ; Febuxostat

PURPOSE: This research was conducted to identify major factors that influence competency for nursing students in basic nursing skills. METHOD: Data were collected by questionnaires from 290 first year students in one college of nursing. The instrument tools included motivation for admission to nursing, concern about fundamentals of nursing, perceived importance of fundamentals of nursing, level of active participation in fundamentals of nursing, number of times to use open Lab, Lab class satisfaction, self-efficacy, self-evaluation and student attitude. RESULTS: There was no significant correlation between competency in basic nursing skills and motivation for admission to nursing, concern about fundamentals of nursing, perceived importance of fundamentals of nursing, or number of times to use open Lab. Competency in basic nursing skill in these students showed a significantly positive correlation to Lab class satisfaction, self-efficacy, self-evaluation, student attitude and level of active participation in fundamentals of nursing. The major factors that influenced competency in basic nursing skills for nursing students were student attitude, self-efficacy and number of times to use open Lab. These factors explained 15.5% of the variance in competency. CONCLUSION: Basic nursing skill practice education programs should be developed to improve self-efficacy and active participation.
Diagnostic Self Evaluation ; Humans ; Motivation ; Pyridines ; Questionnaires ; Students, Nursing ; Thiazoles