Aims: Herbal and medicinal plants bioactive compounds of Jatropha curcas, Piper nigrum and P. betle have been shown to possess therapeutic properties. This study investigates the presence and characterization of phytochemical compounds as well as to evaluate the antimicrobial activities of the methanolic crude extract of the leaves and seeds of J. curcas, P. nigrum L. and P. betle. Methodology and results: The study on antibacterial and antifungal efficacy of the crude extracts of leaves and seeds were carried out using standard disc diffusion method. The crude extracts were found to exhibit an average response of antimicrobial activity with the inhibition zones ranged from 3% to 28% for antibacterial and from 21% to 79% for antifungal activity. Among all extracts, the leaf extract of P. betle showed a good antibacterial activity against Staphylococcus aureus and excellent antifungal properties against Aspergillus niger and A. flavus. The phytochemical screening analysis revealed the presence of saponin, tannins, glycosides, terpenoids, reducing sugar, flavonoid and anthraquinones. However, phlobatannins was not present. Total phenolic content (TPC) and total flavonoid content (TFC) were highly detected in the crude extract of P. betle and recorded as 13.33 mg of gallic acid equivalents, GAE (mg/ 100 mg sample) and 0.88 mg of RE (mg/100 mg sample), respectively. GC-MS analysis of the bioactive compounds reveals the presence of diethyl phthalate, 2-hexadecen-1-ol (Phytol), hexadecanoic acid, piperine, phenol and other minor compounds. Conclusion, significance and impact of study: The study suggested that P. betle has a potential as a source for antimicrobial agent from plants extracts. Nevertheless, further studies are needed to elucidate their precise mechanism of action.
Therapeutics

The randomized Controlled Trial is the standard design to prove the effectiveness of drugs or other forms of interventions. In this type of clinical research, individuals are randomly assigned (randomization) to either of the two or more groups, one with the intervention the other without the intervention being tested or another intervention. When done properly, it can provide the best evidence of effectiveness
Therapeutics

Screening 142 marine organisms extracts with three human cancer cell lines which were experimental grew in laboratory showed that: the number of agent having cytotoxic activity was rather high. Among 142 samples, 37 samples (26.1%) have resistant activity to at least 1 cell line. Of the 37 samples, 19 samples (7%) have resistant activity to two cell lines, 8 samples (5.6%) have resistant activity to 3 cell lines. The samples with remarkable activity have been collected with large quantity for chemical studies according to cytotoxic activity and related information
Neoplasms ; Therapeutics

75 patients (75 eyes) with endogenous endophthalmitis were treated at Department of Glaucoma, National Hospital of Ophthalmology from 01 January 2004 to 31 December 2004. Results: Endogenous endophthalmitis occurred in 0.13% of all cases at Department of Glaucoma and approximately 1% of hospitalized patients. It is more common in male than in female (58.67% vs 41.33%). The mean age is 37.31± 20.14. Patients under 30 years old present a high rate (49.33%). The right eye infection is more often than the left eye (54.67% vs 45.33%). No case of bilateral involvement is detected. 57.3% of all cases are cultivator. Endogenous endophthalmitis is mostly detected from October to December (46.67%). Gram(+) bacteria are the most common pathogens (45.7%). Fungal infection is the least frequent cause. The outcome of treatment for endogenous endophthalmitis is limit, with 57.33% has visual acuity limited to light perception or totally blind. Retinal detachment appears in 10.67% of all cases. 2.67% has ocular atrophy and 18.67% require the necessity for enucleation
Endophthalmitis ; Therapeutics

Prospective study was carried out on 31 patients with severe hypertension treated in Vietnam Heart Institute. Those subjects were treated with intravenously LOXEN in the first 10 hours, measured blood pressure by the Holter. Results: nicardipin (LOXEN) is calci channel blocker with a good antihypertensive effect in treatment of severe hypertension. At initial dose 7.5 - 8.0 mg/hour, after the sixth minute, the drug had effect of antihypertention (p<0.05), at the 18th minute, blood pressure reduced by15%. At the normal dose 2-3 mg/hour by the time of 1, 4 and 10 hour, blood pressure gradually decreased and reached 16%, 22% and 24%, respectively compared to initial blood pressure. Nicardipin is easy to use and well tolerate, there was no patients with allergy or died of the medicament
Hypertension ; Therapeutics

This study comprised 9 eyes with severe myopia of 7 patients (4 male, 3 female) between 36 and 50 years, having phacoemulsification, intraocular lens implantation with suitable capacity. Follow up duration was 12 months. Results: the preoperative uncorrected visual acuity was < 1/10 in all patients. Postoperatively, 55.5% cases with uncorrected visual acuity and 66.7% cases achieved the best corrected visual acuity of 5/10 or better. The mean preoperative hyperopic spherical equivalent was +6,89 ± 1,67D reduced to +0,75±0,62D. Postoperative complications were low: 1 eye had posterior capsule opaque (11,1%), 1 eye had inflammatory membrane. No intraoperative complications
Hyperopia ; Therapeutics

Study was carried out on 80 mechanical energy menorrhagia patients under 18 years of age, treated with rigevidon combined with preventive antibiotics and commonly drugs as oxytoxine, ecgometrine at the Newborn & Mother Protection Hospital in 2000. The results showed that: with single dose of 2 tablets per day, taken in unique time in the evening, and then reduction of dose to 1 tablet per day when bleeding stopped, to make a 28 days menstruation cycle, the good efficacy was observed in 96.25% of patients (77 patients respond well to treatment). After, maintain treatment for 3 months following to make an artificial menstruation cycle then stop completely. All of patients had no any seriously complications, including menorrhagia after stopping treatment
Menorrhagia ; Therapeutics

Objective: to study the ability of cedemex in preventing the spirit dependence (anti readdiction). Animals and method: using the method of position taste with condition to establish the model of spirit dependence to morphine in white house- mouse. Results: Among the mice taking continuously cedemex by 5 days, with 3 different doses, then using hydrocortisone to stimulate, the residence time in white boxes did not last clearly, the behaviour toward preferring white boxes was not recovered and it returned to position state without condition. But in morphine group when using NaCl 9%o, the residence time in white boxes did last clearly, the behaviour toward preferring white boxes was recovered.
Morphine ; Therapeutics

One of the challenges for the current malaria management in the province of Thua Thien - Hue is imported malaria caused by the movement of population across the Vietnam - Laos border and between the malaria endemic areas from Quang Nam to Quang Tri provinces by the newly constructed route of Ho Chi Minh. Under that circumstance, the active measures have been set up for control and prevention of malaria infection, especially for risk cases. These measures appear to be initially effective. The incidence, fatality has been controlled. The risk of imported malaria has been over. However, those measures need to be sustained in the border areas and the Ho Chi Minh route to maintain the achievements
Malaria ; Therapeutics

A randomized controlled trial was carried out on two groups of patients who were received either Flagystatine (nystatin 1000000 UI/metronidazol 500 mg) or Neo Penotran (miconazol 100mg/metronidazol 500 mg), twice a day for 7 days. Gynecological and microbiological assessments were carried out before treatment and 14 days after the first visit. In Flagystatine and Neo Penotran groups, clinical cure rates were 42% and 77.9% respectively; microbiological cure rates were 68.2% and 72.1%. In Neo Penotran group, functional symptoms were reduced more than organic symptom (84.8% and 79.1%, respectively). This difference was not so remarkable in Flagystatine group (64.8% and 65.95, respectively). Side effects of Neo Penotran were insignificant. Neo Penotran therapy without supportive treatment had higher efficacy in vaginitis at dosage of two pill a day in 7 days. The drug showed effects in both of function symptoms and organic symptoms, in clinical and paraclinical
Vaginitis ; Therapeutics