We report that a case of maxillary sinus carcinoma with severe pain for radiation oral mucositis was successfully managed by using indomethacin spray. Fifty three-year-old male who was treated with radiation and chemotherapy including 5-FU for his maxillary sinus carcinoma developed oral mucositis with severe pain. Several medications such as diclofenac sodium (tablet), oxycodone hydrochloride (sustained-release tablet), morphine sulfate (fine granule), fentanyl (patch), azulene (gargle) and lidocaine (viscous) did not provide satisfactory effects on the pain control. We, therefore, tried to use indomethacin spray (0.2 mg/0.08 mL/push) with the daily dose of 9.6±5.2 mg (2-10 push/once, 1-11 times daily). Indomethacin spray provided dramatic effects on his pain relief with the significant reduction of pain score (face scale) from 2.4±0.4 to 1.0±0.1 (p<0.01). Mean time for pain relief was 8.7±2.2 min. after applying indomethacin spray. The effects of indomethacin spray on the radiation oral mucositis were evaluated by pain score in five patients with head-and-neck carcinoma. The pain score was improved in all cases after introducing indomethacin spray (before vs. after: 3.2±0.5 vs. 1.6±0.6, p<0.01) with the 8.1±3.8 mg/day. There was no adverse events associated with the use of indomethacin spray. The results suggest that the use of indomethacin spray is an alternative approach to control the pain for radiation oral mucositis in patients under radiation therapy for head-and-neck carcinoma.

A compalative study of maximal aerobic power (MAP) with special reference to age were carried out as a basic study for determing the optimal physical load for successful living in modern society or in future ages. 169 males who have a sedentary living style profoundly affected by the motorization, 10-69 years of age, in suburban district of Fukuoka City (JAPAN) and 54 males who have a natural living style, 16-55 years of age, in rural districts of Nepal were selected as subjects. Measurement of MAP was made indirectly following to the method of Margaria et al.. Each subject were given two different intensity step up and down exercises, and MAP was calculated from heart rates immediately after exercises and individual's estimated maximal heart rate. % Fat was estimated from skinfold thickness according to the method of Nagamine.
Statistically significant correlations were found both of Japanese group (r= -0.554, P<0.001) and Nepalese group (r=0.561, P<0.001), and each regression equation etween MAP (ml/kg/min) and Age (yr) were as follows :
MAP=-0.350 Age +52.121 in the case of Japanese group.
MAP=-0.446 Age +63.395 in the case of Nepalese group.
However, difference of the regression coefficient was not significant.
Mean MAP per kilogram of body weight or per kilogram of lean body mass of every Japanese age groups wese lower than those of Nepalese groups with coincidental age, respectively. Generally, it is said that the socio-economical condition of Nepal today is a similar to that of Japan in the Meiji era. Therefore, it may be considered that modernization or urbanization have lowerd the system of Japanese people.
According to the review of literatures concerning to the living style and MAP in a evolutional and comparative point of view, it may be considerd that human races have maintained the relatively high MAP like Nepalese group today. Therefore, it is said conclusionally that the maintenance of mean MAP like Nepalese group is desirable in modern society or in future ages to prevent the degeneration of functions attributing the new health problem of modern society.

1. We observed how brain waves change, especially in frequency, during the period of physical exercise training as subjects are becoming more skilful.
2. In the first, subjects, with eyes closed, were given bicycle ergometer load in the hypnotic state, the brain waves of the subjects were clearer when they were suggested that they can pedal easily than when they were suggested that their pedaling is heavy.
3. In the second experiment, we took up a fourteen-year-old school girl as a subject, who had been unable to ride a bicycle and whose brain wave shows no alpha blocking while her eyes are open. Using a radio-telemeter, we took her electroencephalograms every day for about ten days when she was learning bicycle-riding. As a result, we find that her brain waves were complicated at first when she was pedaling with voluntary effort and with others' help, and that they were becoming simpler as she got used to riding, until alpha waves began to appear with her skill in and smoothness of riding.
4. In the third experiment, with a number of novices in skiing as our subjects, we made electroencephalographical observations of them practising on natural snow. In order to avoid the alpha blocking, we imposed the condition that they keep their eyes closed during the experiments. Brain waves were taken by using a radio-telemeter, whose receiver was set in a house and antenna in the middle of an about seventy-meter slow descent course. Because of their closed eyes, they seemed to feel no little fear so that their brain waves were too complicated to analyze and were mixed with electromyographical fluctuations. But as they became more skilled, their brain waves were more normal and simpler, until even alpha waves sometimes appeared during smooth descent skiing.
5. When we learn new exercise, we need higher mental activity using the cerebral cortex in the beginning, but that as we are growing more skilled and more used to the exercise, our mental activity becomes a lower and reflexive one that needs no much participation of the cerebral cortex. And alpha wave become to appear in the brain waves.
6. We discussed that how related our researches are with Jasper and Penfield's beta wave and “rhythme en arceau” of Gastaut and Chatrian in rolandic region blocking owing to the voluntary movement. It may be given a conclusion that electroencephalographic blockings are based on the mental activity of the preparation to voluntary movements.