To clarify the relation between living habitudes in Japan including daily fare and health, the state of health of 21 Japanese-Brazilians living in Japan was investigated. The relation was analyzed based on their views, about the Japanese customs. Only two persons were found to have adapted themselves to the living environment in Japan, 10 persons were not adaptable sufficiently and 9 suffered from maladaptation. Asked why they were not adaptable, they gave personal relations, difficulty in reading and writing, workplace stress, etc. It was also found that at the present their biggest worry concerned the future, followed by personal relations, Japanese language, work and education in that order. Our investigation brought to light the fact that there was much to be done by the local community in terms of receiving immigrants. When it came to foodstuffs, after visiting Japan, the intake of salt, meat and fruit decreased, and fish increased. Like most Japanese, the Japanese-Brazilians regarded salad and rice-baseddiet healthy, but coffee not good. Referring to some foodstuffs which are customarily eaten less, many said they feel eating a lot of fish and shellfish in Japan is good for the health, but little fruit and little bean food are not good. As for the present health condition, more than half of the subjects said they had some problem. In the relation between the change in weight and the change in eating habit, only the increased intake of sugar was related to weight gain. The effect of the Japanese way of life on their health must be continuously followed up on with the common and different points of the customs in eating between Brazil and Japan taken into account.

Today's one of the most important problems both in the industrial hygiene and the community health care is the health protection of farmers who are working in factories. There are many such farmers in the San'in rural districts. We surveyed the working conditions of 370 factories in Shimane Prefecture and found that they had many problems to be solved. The problems in the factories, mostly small-scale factories, are summarized as aging of workers, long working hours, insufficient rest, harmful work and night work.
Even in Sada-cho, where the local government is promoting the comprehensive community health care and encouraging the health care activity of inhabitants, the health care for factory workers is performed insufficiently. Some factories do not carry out even a periodical health examination of the workers.
We established the Sada-cho Occupational Health Association in cooperation with the local government, Izumo Health Center, Shimane Labor Standard Inspection Office and the factories in Sada-cho for the purpose of promoting the unified activity of the industrial hygiene and the community health care.

The exposure to the organophosphate pesticide (DDVP) by sprayers was assessed based on the measurements of concentration in the greenhouse. The serum concentrations of DDVP were examined 1 hour after spraying in two men who worked in the greenhouse with gas masks. Their serum concentration level was 21.2 ng/ml and 15.0 ng/ml, respectively, while serum cholinesterase was within normal level in both men. Changes in aerial DDVP concentrations in the greenhouse were examined. The result showed a higher concentration at the lower point (0.7 m high from the ground) than at the higher point (1.4 m high from the ground). The aerial concentration remained high (0.5ppm-2.0 ppm) for two days after spraying and started to decline thereafter to 0.5 ppm or less. On the seventh day, it was undetectable.
From these results, we suggest that the following precautions should be taken toprevent pesticide exposure in the greenhouse. 1. Wearing only a gas mask but also goggles are recommended when pesticides are being sprayed. 2. The work in the greenhouse should be postponed until the second day after spraying because of the aerial residue of pesticide. 3. The frequent ventilation and gas mask are necessary till the seventh day after spraying. 4. Ventilation of the zone near the ground should be done sufficiently when the workers take the half-sitting posture like “buds gathering, ” because they are exposed to higher aerial concentrations of pesticide than when they are working in a standing posture.

To investigate the problems confronting the present health care system for the elderly in depopulated areas of Japan, we examined the living conditions of solitary aged people in two rural communities, Sada and Koryo, Shimane Prefecture, where the percentage of aged population is the highest among all the prefectures in Japan. Just as community characteristics ofthe two areas are different from each other, so are the features of the elderly's health needs.
Sada is a mountainous agricultural community, where the acreage of cultivated land per household is relatively large. As many families are composed of three generations, only a small number of aged people are living by themselves.
Koryo is a urbanized agricultural community on the outskirts of Izumo City. As the acreage of cultivated land per household is narrower, the average number of family members is smaller, and the percentage of the elderly, especially female, living alone is remarkable.
In Sada as well as Koryo the solitary life of the elderly mostly resulted from the death of their spouse. Their daily contact with their children is scarce, because most childrenlive in big cities far away from their parent's home. The rate of the solitary elderly whose children and their family will return home in future is 27.0% in Sada and 43.4% in Koryo.
Most of the social problems the solitary elderly face are derived from strained household economy. The rate of the elderly whose living expenses are less than 60, 000 yen a month is 41.2% in Sada and 31.6% in Koryo. As the economic resources of the solitary elderly are generally meager, the community should gear up to meet their economic needs.

Epidemiological surveys suggest an important role for niacin in the causes of Parkinson's disease, in that niacin deficiency, the nutritional condition that causes pellagra, appears to protect against Parkinson's disease. Absorbed niacin is used in the synthesis of nicotinamide adenine dinucleotide (NAD) in the body, and in the metabolic process NAD releases nicotinamide by poly(ADP-ribosyl)ation, the activation of which has been reported to mediate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. Recently nicotinamide N-methyltransferase (EC2.1.1.1) activity has been discovered in the human brain, and the released nicotinamide may be methylated to 1-methylnicotinamide (MNA), via this enzyme, in the brain. A deficiency in mitochondrial NADH: ubiquinone oxidoreductase (complex 1) activity is believed to be a critical factor in the development of Parkinson's disease. MNA has been found to destroy several subunits of cerebral complex 1, leading to the suggestion that MNA is concerned in the pathogenesis of Parkinson's disease. Based on these findings, it is hypothesized that niacin is a causal substance in the development of Parkinson's disease through the following processes: NAD produced from niacin releases nicotinamide via poly(ADP-ribosyl)ation, activated by the hydroxyl radical. Released excess nicotinamide is methylated to MNA in the cytoplasm, and superoxides formed by MNA via complex I destroy complex 1 subunits directly, or indirectly via mitochondrial DNA damage. Hereditary or environmental factors may cause acceleration of this cycle, resulting in neuronal death.

The new community-based curriculum in Shimane Medical University, Japan, which are mainly based on family health practice and community health approach, is useful for students to understand the comprehensive medicine and holistic approach to community-based primary health care.
It is important to introduce district health workers in the preventive education for medical students to obtain to humanistic attitude and to change their value and behavior.
The importance of the exposure to the community health activities organized with man power and social resources should be more stressed in the improvement of the medical education curriculum and also of educational methodology to learn the essential physicians' nature such as humanity, responsibility, cooperation, positive attitude, and ability of problem solving.