1.Multiple system atrophy in a patient with primary ciliary dyskinesia
Hideya Sakaguchi ; Satoshi Yamashita ; Tomohiro Suga ; En Kimura ; Yasushi Maeda ; Teruyuki Hirano ; Makoto Uchino
Neurology Asia 2013;18(1):103-105
We present the case of a patient with primary ciliary dyskinesia who later developed clinically probable
multiple system atrophy. Multiple system atrophy is a sporadic neurodegenerative disorder clinically
characterised by various combinations of parkinsonism, cerebellar ataxia, autonomic failure, and
pyramidal sign. Primary ciliary dyskinesia is a genetically heterogeneous disorder of motile cilia and
results in chronic bronchitis, bronchiectasis, chronic rhinosinusitis, chronic otitis media, situs inversus,
and male infertility. Most of the causative genes for primary ciliary dyskinesia encode proteins that
are part of the heavy or intermediate chain of axonemal dynein in ciliary outer dynein arms. We
hypothesised that axonemal dynein dysfunction in primary ciliary dyskinesia results in reduced autophagy,
accompanied by impaired cytoplasmic dynein function, which in turn accelerates -synucleinopathy in
multiple system atrophy. Furthermore, we contemplated a potential association between primary cilia
and neuronal function. Although it is not yet clear if a causal link between multiple system atrophy
and primary ciliary dyskinesia exists, further investigation into the relationship between axonemal
dynein dysfunction in primary ciliary dyskinesia and α-synucleinopathy should be conducted.
5.Antiplatelet Therapy May Be Insufficient to Prevent Stroke Recurrence Before Percutaneous Patent Foramen Ovale Closure
Hiroyuki KAWANO ; Yuko HONDA ; Takashi JOHNO ; Hibiku MARUOKA ; Kaoru NAKANISHI ; Mikito SAITO ; Kensuke OGATA ; Atsushi YAMAMICHI ; Ayane KAWATAKE ; Teruyuki HIRANO
Journal of Stroke 2023;25(2):307-310