Objective: To determine the effect of pre-operative isometric exercise (PIE) on vascular caliber of pediatric chronic kidney disease (CKD) Stage 2-5D patients. Materials and Methods: This is a single-blind, randomized, single-center trial of 28 CKD patients. Fourteen participants allocated in the intervention group (PIE) were provided with a handgrip device and performed handgrip exercise consisting of two sets of 30 contractions daily while another 14 participants did not perform the exercise and were considered as controls (NE). For both groups, Duplex Ultrasonography was performed at baseline, four and eight weeks post-intervention. Results: Twenty-four CKD patients were included and analyzed. The mean age was 15.8 (+/- 1.9) years. There were 16 (66.7%) females and eight (33%) Males, 10 (41.7%) underweight (<18 kg/m2 ), 23 (95.8%) right-handed, 12 (50%) with Chronic Glomerulonephritis, and 10 (41.7%) with stage 2 CKD. Both the intervention and control group revealed a statistically significant increase in the caliber of the non-dominant cephalic (ante-cubital) vein at four- and eight-weeks post-intervention. Conclusion PIE might not significantly impact vessel diameter in pediatric CKD population as compared to adult CKD patients. Further studies on reliability of ultrasonography of blood vessels utilizing a larger sample size and more controlled milieu are recommended.
Renal Insufficiency, Chronic

Introduction: Musculoskeletal complaints have been observed in the recovery phase of patients with moderate-to-severe coronavirus disease 2019 (COVID-19). We noted several referrals for physical rehabilitation at the University of the Philippines-Philippine General Hospital (UP-PGH), a designated COVID-19 referral center. These observations resembled the musculoskeletal manifestations associated with poorer outcomes reported in other coronavirus studies. Objectives: The study determined the musculoskeletal signs and symptoms of adults in the recovery phase of moderate to severe COVID-19 using the COVID Musculoskeletal Assessment Tool (CMAT). Methods: This was a three-phased, prospective, descriptive study of adults admitted for COVID-19 at the UP-PGH. Phase 1 was the development of the CMAT based on a review of related literature and patient charts, and patient interviews. The tool was pretested and validated in Phase 2 before it was used in the evaluation of study participants in Phase 3 of the research. Data was encoded using Microsoft® Excel 2007 and analyzed using STATA, Version 12.0 (Texas, USA). Descriptive statistics were used to summarize the variables collected for the study. Results: A cohort of 40 patients admitted at the UP-PGH for moderate-to-severe COVID-19 infection was evaluated using the CMAT. Most of the patients had an average age of 55 years and were males. Majority resided in an urban area, reached high school education, and were ambulatory before their illness. The most common comorbidities were hypertension and diabetes. All patients required oxygen support. Based on the CMAT, majority of the participants complained of muscle pain, generalized weakness, and easy fatigability. Other common findings were neck-shoulder and lower limb pain, dyspnea on exertion, limited mobility in the trunk, hips, and knees, joint pains, and decreased muscle strength. Half of the participants needed a wheelchair or walker to ambulate. These findings may be due to the COVID-19 disease and to prolonged confinement in bed. Only one patient underwent physical therapy through bedside instructions. Conclusion Musculoskeletal signs and symptoms were common in the patients recovering from COVID-19 disease. The COVID-19 Musculoskeletal Assessment Tool facilitated the evaluation of patients and the recording of results. Early referral for medical rehabilitation and timely intervention are strongly recommended.
COVID-19 ; Coronavirus ; Myalgia