1.High prevalence of diabetes in stroke patients and its association with lacunar infarction
Zhe Kang Law ; Wan Nur Nafisah ; Ramesh Sahathevan ; Jee Yong Hing ; Mohd Firdaus Zakaria ; Nurul Munirah Mohd Shuhari ; Nur Fathihah Ahmad ; Teong Kui Ting ; Hui Jan Tan ; Shahrul Azmin ; Rabani Remli ; Azmawati Mohammed Nawi ; Norlinah Mohamed Ibrahim
Neurology Asia 2015;20(2):121-127
Background & Objectives: The burden of stroke is increasing, in part due to increasing prevalence of
diabetes mellitus. Given the high prevalence of diabetes in the Malaysian population (22.6%), we aimed
to determine the prevalence of diabetes in our stroke population. We also aimed to study the stroke
subtype associated with diabetes. We hypothesized that lacunar infarction would be more prevalent
in diabetics. Methods: We retrospectively reviewed data of consecutive patients with acute ischaemic
stroke admitted from October 2004 to December 2010 from our stroke registry. Demographic data, risk
factors profile and stroke subtypes were reviewed and analyzed. Results: Eight hundred and fifty eight
patients were identified from the registry. As high as 59.3% (n=509) of our patients were diabetics,
of which 49.2% (n=422) had pre-existing diabetes and 10.1% (n=87) were newly diagnosed. Lacunar
infarction was the commonest stroke subtype, comprising 60.6% (n=519) of all strokes. Diabetes was
significantly associated with lacunar infarction (OR 1.5, CI 95% 1.16-2.01, p=0.003), particularly in
those aged ≤ 55 years (OR 2.29, 95% CI 1.12-4.67) and HbA1C ≥ 6.5% (χ²=8.77, p=0.003).
Conclusions: The prevalence of diabetes in our stroke patients is amongst the highest reported.
Diabetes mellitus, particularly those with poor glycaemic control is strongly associated with lacunar
infarction.
Diabetes Mellitus
;
Stroke
Result Analysis
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