Objective To explore the clinical features of hypertrophic cardiomyopathy (HCM) in aged patients in China. Methods The 711 patients with HCM in our hospital from Sep 2002 to Sep 2008 were retrospectively reviewed. Clinical data were compared between patients older and younger than 65 years. Results The 103 patients(14.5%) were older than 65 years. Compared with those patients younger than 65 years, the aged patients had a higher prevalence in female (52. 5 vs 29. 0%, P<0. 01), in comorbidity (64. 1% vs 25.0%, P<0, 01)and in atrial fibrillation (21.4% vs 14.0%, P<0. 05). Cardiac insufficiency was the most common symptom in aged patients with HCM. The age(r=0. 213, P<0. 05), size of left atrium (r=0. 308, P<0. 01) and atrial fibrillation (r= 0. 362, P<0. 01) had significant correlation with heart function. The 24 % of patients had one or more major risks for HCM-related sudden cardiac death (SCD), among which syncope was most common. Conclusions A higher prevalence of comorbidity, a higher incidence of atrial fibrillation and worse heart function existed in aged patients with HCM. The major risks for HCM-related SCD should not be neglected in evaluation for aged patients.

Objective:To detect the expression levels of T cell immunoglobulin mucin-3 (Tim-3) in peripheral blood natural killer (NK) cells of patients with oral squamous cell carcinoma (OSCC) and to study their biological and clinical significance.Methods:The expression of Tim-3 in the CD3-CD56 + NK cells was examined in 72 patients with OSCC and 40 heathy controls (HC) by flow cytometry.The correlation of Tim-3 expression in NK cells with clinicopathological parameters was analyzed.Results:The proportion of CD3-CD56 + NK cells was significantly decreased in OSCC patients as compared with HC [(9.30 ± 2.52)％ vs (17.36 ± 3.15)％,P ＜ 0.001].The percentage of Tim-3 + CD3-CD56 + NK cells in OSCC patients was higher than that in HC [(14.35 ± 6.35) ％ vs (1.78 ± 0.86) ％,P ＜ 0.001].High percentage of Tim-3 + CD3-CD56 + NK cells was associated with cell differentiation,lymphatic metastasis and pathological stage of OSCC (P ＜ 0.01).Conclusion:Lower proportion of NK cells and higher level of Tim-3 in peripheral blood NK cells may play a role in the development of OSCC.

Cardiomyopathy, Hypertrophic ; complications ; pathology ; Electrocardiography ; Female ; Heart Aneurysm ; complications ; pathology ; Heart Ventricles ; pathology ; physiopathology ; Humans ; Middle Aged

Objective Septal reduction therapies were recommended for drug-refractory patients with hypertrophic ob-structive cardiomyopathy(HOCM).To explore and compare the effectiveness and safety in patients with hypertrophic obstruc-tive cardiomyopathy(HOCM) treated with surgery myectomy(SM) and alcohol septal ablation(SA).Methods The clinical data of 260 patients performed SA(n=184) or SM(n=76)between September 2002 and September 2014 in our institute were retrospectively reviewed.The t-test, rank sum test and chi-square test were used to compare the differences between the two groups, and the Cox regression model was used for multivariate survival analysis.All-cause mortality, cardiac cause death(peri-operative death were included ) , heart function improvement , procedure-related complications and permanent pacemaker de-pendence( PPM) constituted the main contents of this study .Results Compared with patients treated with SM , patients un-dergone SA were poor heart function status(2.97 ±0.29 vs 2.50 ±0.56, P =0.01), more prevalence of atrial fibrillation( 15.14％ vs 6.80％, P=0.046) and longer follow-up period[(5.4 ±3.8) years vs(2.5 ±2.2) years, P =0.01)].All-cause mortality for SA and SM were 3.3％ and 14.5％ respectively(P=0.001).The fatal cardiac events of SA and SM were 1.63％ and 13.16％ respectively(P<0.001).Sudden cardiac arrest were the main cardiac cause death for both patients trea-ted with SA and SM.The cardiac death of left ventricular systolic dysfunction was main found in patients treated with SM . Heart function improvement(NYHA) after SA and SM were 1.23 ±0.61 and 0.88 ±0.64 respectively(all P <0.01).And SA had a lower procedure-related PPM implantation(1.63％ vs 4.20％, P<0.05).Conclusion Our results shown that SA have survival advantage, lower PPM and similar heart function improvement compared with SM for refractory patients with HOCM.

Desmoid tumor is a rare, locally-invasive fibromatosis with a high recurrence rate and non-metastatic features. Here, we reported a 62-year male patient with desmoid tumor in the superior sulcus of left lung, complaining of cough, chest pain, limited-movement, and pain on the left upper arm. We performed extended resection of the tumor, including wedge resection of the left upper lobe, resection and anastomosis of partial left subclavian artery, resection of T1 nerve root, cauterization of adhesive pleura, and resection of the left first and second ribs. After surgery, the patient's symptoms were relived. The duration of hospital stay was 8 d. This is the first reported case of surgical treatment for the superior sulcus desmoid tumor.