One-hundred and twenty 4-week-old Wistar rats were selected.After making the model of goiter by iodine deficiency,the rats were divided into 4 groups:normal control group (NC),model control group (MC),excessive iodine group(IE) and herbs rich in iodine group (HIE).The rats were killed 0 week and 8 weeks after different treatments.The activity of rat serum glutathione peroxidase (GSH-Px),xanthineoxidase (XOD),and superoxide dismutase (SOD),as well as the levels of malondialdehyde (MDA) and hydrogen peroxide (H2O2),were measured by biochemical methods.The expression of 4-hydroxynonenal (4-HNE) in the rat thyroid was detected by immunohistochemistry method.The expression of peroxiredoxin5 (PRDX5) in the rat thyroid was detected by the Western blotting and immunohistochemistry.After 8 weeks of different treatments,the SOD activities in IE group decreased significantly compared with HIE group(P＜0.05).While the GSH-Px activities in IE group and HIE group decreased significantly compared with MC group (both P ＜ 0.01),the values of H2O2 in IE group increased significantly compared with NC group (P＜0.05).The values of MDA in IE group increased markedly compared with HIE group (P＜0.05).The XOD activities in IE group and HIE group were significantly higher than NC group.(both P＜0.01).The expression of thyroid 4-HNE in IE group was significantly higher than HIE group(P＜0.05).The expression of thyroid PRDX5 in HIE group was markedly higher than that in the other groups,as shown by both immunohistochemistry and Western blotting methods (all P＜0.05).Compared with excessive iodine intake,herbs rich in iodine may cause less damage to thyroid follicular cells and make iodine deficiency induced goiter recover more completely,suggesting that this improved result may be related to the enhanced antioxidant capacity,owing to administering iodine-rich herbs.

OBJECTIVETo observe the effects of rehabilitation training (RT) combined with intradermal needling, RT combined with acupuncture and RT alone on core muscle stability in children with cerebral palsy, and to explore the superior therapy to improve core muscle stability in children with cerebral palsy.

METHODSA total of 120 children with cerebral palsy aged from 2 to 4 years old were randomly divided into a RT and intradermal needling group (group A), a RT and acupuncture group (group B) and a RT group (group C), 40 cases in each one. The patients in the group C were treated with kinesitherapy and core muscle stability training, once a day. Along with identical RT of group C, the patients in the group B were treated with acupuncture (once a day), while the patients in the group A were treated with intradermal needling at Yaoyangguan (GV 3), Mingmen (GV 4), Jiaji (EX-B 2, L-L), and 4-week treatment was taken as one course. The integrated electromyography (iEMG) of surface electromyography, root mean square (RMS) and mean power frequency (MPF) of erector spinae muscles, Berg balance scale as well as B area (siting), C area (climbing and kneeling), D area (standing) and E area (walking, running and jumping) of gross motor function measure (GMFM) were compared before and after 3-course treatment.

RESULTS① Compared before treatment, the iEMG and RMS of erector spinae muscles in the group A and group B as well as MPF in the group A were all increased after treatment (all <0.05); after treatment, all the electromyography indexes in the group A were higher than those in the group B and group C (all <0.05); the RMS in the group B was higher than that in the group C (<0.05). ② Compared before treatment, the Berg balance scale was all increased after treatment in the three groups (all <0.05), and the scale in the group A was higher those that in the group B and group C (both <0.05). ③ Compared before treatment, the B area and C area of GMFM in the three groups as well as D area in the group A and group B were all improved after treatment (all <0.05); the B area, C area and D area in the group A and group B were higher than those in the group C (all <0.05); the B area and C area in the group A were higher than those in the group B (both <0.05).

CONCLUSIONBased on RT, the intradermal needling could better improve core muscle stability and balance-motor ability in children with cerebral palsy, which is superior to regular acupuncture and RT alone.