Thyroid hormones play important roles in growth, development, and metabolism of various cells and tissues. It has been assumed for a long time that thyroid hormones are lipophilic and enter cells by passive diffusion, but it has become increasingly clear that cellular uptake and efflux of thyroid hormones are mediated by transporters. The discovery of these thyroid hormone transporters will lead to a better understanding of the tissuespecific regulation of thyroid hormones.

Antibodies, Antineutrophil Cytoplasmic ; analysis ; immunology ; Antibodies, Antinuclear ; analysis ; immunology ; Antigens, Nuclear ; immunology ; Arthritis, Juvenile ; immunology ; Autoantibodies ; analysis ; immunology ; Humans ; Monitoring, Physiologic ; methods ; Nucleosomes ; immunology ; Phospholipids ; immunology ; Rheumatic Diseases ; immunology ; physiopathology

Objective To observe the clinical efficacy ofShenqi Unguent on sub-clinical hypothyroidism patients with qi-deficiency constitution.Methods A total of 60 patients were randomly divided into treatment group and control group. The treatment group took the traditional Chinese medicine ofShenqi Unguent, while the control group took euthyrox orally for 6 months. Changes of carotid intima-media thickness (CIMT), thyroid function (FT3, FT4, TSH, TG-Ab, TPO-Ab), and TCM syndrome integral before and after treatment of the two groups were observed. Results After treatment, the TCM syndrome integrals of the treatment group were significantly improved, compared with the control group (P<0.01). Similarly, CIMT of the treatment group were obviously increased, compared with the control group (P<0.05). Meanwhile, levels of serum TG-Ab and TPO-Ab were distinctly reduced than that of the control group (P<0.01).ConclusionShenqi Unguent has marked clinical efficacy on sub-clinical hypothyroidism patients with qi-deficiency constitution.

hypothyroidism is a common subclinical disease in endocrinology. Its diagnosis is based on an elevated serum TSH but normal FT 4 levels. The adverse outcome of subclinical hypothyroidism is progressing to overt hypothyroidism with an increased risk for atherosclerosis and myocardial infarction . Two factors may affect the development of overt hypothyroidism: the levels of serum TSH and thyroid autoantibodies and both factors have additional effects on the outcome. The benefits of treatment with T 4for preventing the development of overt hypothyroidism is not yet certain; subclinical hypothyroidism is a strong indicator of risk for atherosclerosis and myocardial infarction, just like other known major risk fators such as hypercholestrolemia, hypertension, smoking and diabetes (odds ratio for aortic atherosclerosis 1.9; odds ratio for myocardial infarction 3.1). The treatment with T 4 for the patients could reduce the levels of serum cholesterol. The effects of subclinical hypothyroidism in pregnant women on the IQ of their children have been widely focused. According to the results from a published epidemiological study, the normal reference values of TSH, thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) detected by immunochemiluminesence assay (ICMA) method and the cut-off values of TPOAb and TgAb associated with thyroid diseases have been proposed.

For the first time,the iodine-induced thyroid diseases group of China Medical University has finished a five-year prospective epidemiological study on the incidences of thyroid diseases in the three communities with various levels of iodine intake.The results indicated that increased incidences of subclinical hypothyroidism and autoimmune thyroiditis in the communities with more than adequate and excessive iodine intake.The individuals with positive thyroid autoantibodies at baseline more likely became hypothyroid due to more than adequate and excessive iodine intake.These adverse effects are mainly involved in the susceptible populations for thyroid diseases.Hence it appears to be reasonable that iodine supplementation should be conducted by localization and individualization.

Objective:To investigate the Ki-67,MMP-7,MMP-2 expression in cervical intraepithelial neoplasm(CIN)and cervical cancer,with the aim of evaluating their association with the development,aggressiveness and lymph node metastasis.Methods:The immunohistochemical S-P method and image analysis were used to detect Ki-67,MMP-7,MMP-2 expression in 50 cases with cervical cancer,23 cases with CIN and 20 cases of normal control.Results:Ki-67,MMP-7,MMP-2 were mainly expressed in the membrane and /or cytoplasm in tumor cells.The positive rate of Ki-67,MMP-7and MMP-2 were 72.00%,78.00%,76.00%in carcinoma,47.83%, 60.87%,56.52%in CIN lesions,10,0,0 in normal cervical tissues respectively.Expression rate in ICC was obviously higher than that in control group(P0.05).High grade diseases and those with lymph node involved presented with higher ki-67 expression than low grade diseases and those without lymph node metastasis(P

Objectives:To evaluate the diagnostie value of 16 row helical CT with application of volume viewer. Methods:A retrospective analysis of 52 patienis'numerical data was made. All patients with clinical suspected cerebral vessels disease were detected by the 16 row helical CT angiography with application of voltume viewer, and the imaging data were compared with those of DSA or pathology. Results:of 52 cases,a total of 33 intracranial aneurysms were detected by the application of volume viewer, which clearly displayed the body, neck and parenl artery of intracranial aneurysms, and showed the aneurysms relation with peripheral vessels and cranioaural. In 52cases, 8 cases of cerebral vascular malformations showed Ihe form, the size and the hemisphere of cacogenesis cerehral vessels, as well as the amount of feeding artery and draining vein. In 2 case Moyamoya disease, 16 row helical CT angiography showed paragraph of obliteration Cerebral vessels and branch stem paraplasm. Conclusion:There is clinical application value in 16 row helical CT angiography for the diagnosis of cerehral vessels disease, which provides guidance fur clinical treatment.

Objective To explore the TCM syndrome and its distribution regularity of premature ovarian failure(POF) as well as the relation between the etiological factor and TCM syndrome of it.Methods The pathogenetic condition and etiological factor of 122 patients with POF were surveyed,and TCM syndrome differentiation was carried out on them.Results The TCM symptoms of POF manifested the tendency of variety.Among the 122 cases,Gan-stagnation and Shen-deficiency type accounted for 33.61% of them,Gan-Shen yin deficiency type for 18.03%,Pi-Shen yang deficiency type for 15.57%,Jin damage due to excessive heat type for 15.57%,Shen-deficiency blood stasis type for 8.20%,and Gan-stagnation and Pi-deficiency type for 7.38%.The influence of modern living environment and life style to the disease was found in 68.03% of the patients’ case history.31.15% of the patients was induced by emotion,31.97% by drugs and disease,and 4.92% by both of them.In patients induced by emotion,the proportion of Gan-stagnation and Shen-deficiency type was the highest as compared with the other types(P0.05).Conclusion Gan-stagnation and Shen-deficiency type,Gan-Shen yin deficiency,Pi-Shen yang deficiency type and Jin damage due to excessive heat are the commonly encountered syndromes in patients with POF.Besides the congenital,Shen-Qi and Chong-Ren Qi-blood insufficiency as well as the genetic factor,the modern living environment and life style have the promotion in the genesis of POF.

Contrast induced nephropathy(CIN)has become the third leading cause of hospitalized acquired nephropathy, with high morbidity and mortality involving the use of iodinated contrast media especially in patients already suffered from renal insufficiency. This complication has been recognized gradually, however, it is still oftenly ignored by the diagnostic and interventional radiologists. The prevalence, definition, risk factors, prevention and treatment, and prognosis have been reviewed in this article. It is addressed that increasing the realization of CIN is the key factor to prevent and manage such a complication for every interventional radiologist.

OBJECTIVE: To clarify the pathogens in plateau hospital-acquired pulmonary infection and their antimicrobial susceptibility so as to provide scientific basis for clinical first-line treatment in the rational use of antibacterial drugs. METHODS: The bacteriological culture and drug susceptibility experiment on sputum and bronchial douche fluid collected from 1 396 patients with hospital-acquired pulmonary infection in our hospital from 2004 to 2006 as well as the filed medical records were analyzed retrospectively. RESULTS: 789 positive bacteria were isolated, of which, 77.82% (614/789) were gram-negative bacilli (GNB), with Klebsiella spp showing the highest percentage, accounting for 53.91% (331/614); 21.04% (166/789) were gram-positive bacteria, with staph showing the highest percentage, accounting for 46.99% (78/789).Most of the GNB were sensitive to imipenem, sulbactam/cefoperazone, then to aminoglycosides. The susceptibility rate of Gram-positive bacteria to vancomycin was 90.36%. CONCLUSION: Gram-negative bacilli were the main hospital infection pathogens, which were sensitive to imipenem, sulbactam/cefoperazone but highly resistant to ceftazidime, which calls for attention in the clinic.