Constraint-induced movement therapy (CIMT) is a new approach to rehabilitation of movement in patients after neurological injury and increase their functional independence. This approach has been demonstrated to successfully transfer improvement in the quality and amount of upper extremity use from clinic to the real-life setting. The main purpose of this article is to describe the component and unique aspects of CIMT protocol according to the author's observation in CIMT laboratory at the University of Alabama at Birmingham (UAB).