1.Therapeutic effect of processed aconiti tuber on rheumatoid arthritis and its pharmacological analysis.
Koshiro CHIKAZAWA ; Shigeo ARAKI ; Taro TAMADA ; Kiyoo ITOH ; Hiroshi ITOH ; Motoo ARAI
Kampo Medicine 1987;37(4):297-304
It is well known that aconitine-alkaloids is effective for treatment of rheumatoid arthritis (RA). However, the clinical use is limited in part because of its side effects. In this study we examined the therapeutic effects of newly processed “bushi” (Shujibushi) in which the contents of original forms of aconitines were reduced to aboid their undesirable effects. The effectiveness of the “Shujibushi” was recognized in 65.8% (45/67) for clinical and definite RA and in 80.7% (21/26) for probable RA. There were not any adverse side effects.
In order to obtain possible explanations for the high effectiveness of the “Shujibushi”, we analized ingredients of the “Shujibushi” in comparison with “Uzu” another type of aconitine-alkaloids medicine. The “Shujibushi” contained the significantly larger amounts of total alkaloids compared with “Uzu”. The satisfactory effectiveness of the “Shujibushi” might be brought on by the high content of total alkaloids which seem to be composed of aconitine-metabolites and its original forms.
2.The Efficacy of Choreitogoshimotsuto for Radiation Hemorrhagic Cystitis
Satoshi TAMADA ; Minoru KATO ; Takeshi YAMASAKI ; Sayaka YASUDA ; Taro IGUCHI
Kampo Medicine 2022;73(2):187-189
We investigated the efficacy of choreitogoshimotsuto for radiation hemorrhagic cystitis. Of the 11 patients who could be followed up, hematuria disappeared in 8 cases. The median time to disappearance of gross hematuria was 74 days. There was no recurrence. Of the 3 ineffective patients, one had urinary diversion, and two had transurethral electrocoagulation and hyperbaric oxygen therapy. There were no adverse events associated with the use of choreitogoshimotsuto. Choreitogoshimotsuto might be effective for radiation hemorrhagic cystitis.
3.Simultaneous quantification of pyrethroid metabolites in urine of non-toilet-trained children in Japan.
Jun UEYAMA ; Yuki ITO ; Risa HAMADA ; Naoko OYA ; Sayaka KATO ; Taro MATSUKI ; Hazuki TAMADA ; Kayo KANEKO ; Shinji SAITOH ; Mayumi SUGIURA-OGASAWARA ; Takeshi EBARA ; Michihiro KAMIJIMA
Environmental Health and Preventive Medicine 2022;27(0):25-25
BACKGROUND:
Pyrethroid (PYR) insecticides are widely used for controlling various pests. There are two types that differ in terms of usage: agricultural-purpose PYR (agriculture-PYR) and hygiene purpose PYR (hygiene-PYRs). Few studies exist on the exposure to these chemicals in small children. In this study, we conducted biomonitoring of urinary pyrethroid metabolites in 1.5-year-old children throughout the year.
METHODS:
Study subjects were 1075 children participating in an Aichi regional sub-cohort of the Japan Environment and Children's Study as of 18-month health check-up. The concentrations of four specific hygiene-PYR metabolites including 2,3,5,6-tetrafluoro-1,4-benzenedimethanol (HOCH2-FB-Al), and five common metabolites of hygiene- and agriculture-PYRs including 3-phenoxybenzoic acid (3PBA) and cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (DCCA), were measured in urine samples extracted from soiled diapers using a triple quadrupole gas chromatograph-mass spectrometer.
RESULTS:
The highest detection frequencies were for 3PBA, followed by DCCA, 1R-trans-chrysanthemum dicarboxylic acid, and HOCH2-FB-Al. Among the six metabolites, urinary concentrations were seasonally varied. However, this variation was not observed in the most studied PYR metabolite, 3PBA. Spearman's correlation analysis demonstrated a significant positive correlation between FB-Al and DCCA (r = 0.56) and HOCH2-FB-Al and 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol (r = 0.60).
CONCLUSIONS
This biomonitoring survey found widespread and seasonally specific exposure to multiple hygiene- and agriculture-PYRs in 1.5-year-old Japanese children.
Agriculture
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Child, Preschool
;
Environmental Exposure/analysis*
;
Humans
;
Infant
;
Insecticides
;
Japan
;
Mass Spectrometry
;
Pyrethrins/urine*