Objective:To study the influence of cusp inclination of artificial posterior teeth on abutment displacement of unilateral distal-extension telescope crown denture.Methods:Study models of mandibular unilateral distal-extension and telescope crown dentures with the cusp inclination of 0?,12?,25? and 33? were respectively prepared. When food chip was masticated on the occlusal surface and the dentures were loaded by 29.4 N, 49 N or 68.6 N, the abutment displacement was measured.Then the data were calculated and reciprocally compared with statistical analyses. Results:Between anatomic and 25? semi-anatomic artificial posterior teeth, there were significant differences in the buccolingual and vertical abutment movement(P0.05). The parallel, inclination, twist-like and vertical movement of abutment increased with the increase of the load on the denture. The difference among different level of load was statistically significant (P

Objective To evaluate the efficacy of recombinant tissue-type plasminogen activator(rt-PA)and mild hypothermia for acute cerebral infarctions. Methods72 patients consistent with the inclusion criteria were randomly divided into 2 groups,hypothermia group receivied rt-PA combined with mild hypothermia and control group receiving rt-PA only.Neurological functions was evaluated with European Stroke Scale(ESS). ResultsAs intravenous thrombolytic therapy within 6h after the onset,the ESS scores examined 3 days after thrombolysis in hypothermia group was significantly higher than those in control group.As intravenous thrombolytic therapy during 6h to 12h after the onset,the ESS scores of hypothermia group increased more significantly from 24h after thrombolysis than those in control group. Conclusionft-PA combined with mild hypothermia was more effective than rT-PA only for acute cerebral infarctions,which was effective and relatively safe in the treatment of acute ischemic cerebral vascular disease.

Atrial tumor myocytes (AT-1 cells) were derived from tumor-bearing mice in which SV40 T large antigen drives atrial natriuretic promoter. AT-1 cells possess many features typically seen in cardiac cells from other species, such as spontaneous beating, multiple ion channels and responses to drugs, etc. Major ion channels are present in AT-1 cells: sodium, calcium and potassium channels. Sodium channel in AT-1 cells is highly sensitive to blocker tetrodotoxin. L- and T-type calcium channels respond to classical blockers. An important outward potassium current in AT-1 cells is the rapidly-activating delayed rectifier (IKr). IKr Is the sole time-dependently repolarizing potassium current in AT-1 cells. AT-1 cells are a very useful tool for studies in cardiac electrophysiology and pharmacology. As yet, a great number of cardiac and non-cardiac drugs have been tested for their IKr blocking actions in AT-1 cells. The polymorphic ventricular arrhythmia (torsade de pointes) is a severe side effect of IKr blockers.

Objective To compare of pregnancy induced hypertension caused postpartum hemorrhage by two treatment methods. Methods 104 patients with pregnancy induced hypertension were randomly divided into misopr-ostol plus oxytecin group ( observation group)54 cases and the control group ( 50 eases ), used oxytcoin alone, respec-tively, Results postpartum hemorrhage in The observation group of is five cases(9.2% )which was significantly low-er than the control group of 11 cases(22.0% ) ( X2= 3.95 ,P<0.05 ). average postparttun hemorrhage in observation group is ( 195.6±88.4) ml which was significantly lower than the control group (303.2±111.6) ml (t=2.31, P<0.05). Conclusion Misoprostol combined with oxytocin is effective, safe and convenient to patients with postpartum hemorrhage caused by pregnancy induced hypertension.

[Summary] The pathogenesis of type 1 diabetes has not been thoroughly understood. MicroRNA is a kind of small molecule RNA in regulating gene expression at post-transcriptional level. The dysfunction and amount changes of microRNA involve in the regulation of pancreaticβcell volume and function,and thus are related to type 1 diabetes. Here,we reviewed the research advances of microRNA in the development of the pancreas,insulin secretion and type 1 diabetes.

Objective To investigate the occupational exposures to skin injuries among undergraduate nursing students and analyze the causes,so as to provide advices for the standardized pre-service education of occupational protection.Methods To survey 260 students by simple sampling method using self-made questionnaire retrospectively at the end of the internship.The factors influencing skin injuries were analyzed.Results A total of 238 effective questionnaires were obtained.There were 96.64％ (230/238) practice students suffered skin injuries,the incidence rate was higher at the initial phase.The injuries-risk factors were using hollow needles and glass ampoule,dispensing and back to the set of the needle cap.The preventive measures which the students executed were squeezing out blood,washing with flowing water and sterilizing with iodine and alcohol.Only 58.47％ (473/809) students checked the reports of patients.Most of them were lack of the preventive awareness.Conclusions This study demonstrated that skin injuries occurred frequently among undergraduate nursing students of bachelor degree and their knowledge level about precautions was low.The standard education of pre-service occupational prevention,the occupational exposure post-processing and the reporting system were very necessary.

Transforming growth factor β( TGF-β) plays an important role in regulating cell proliferation , differentiation and apoptosis , and also in the carcinogenesis .Unlike its tumor suppressor function in normal tissue , continuous activation of TGF-βsignaling pathway in inflammatory microenvironment and cancer tissue promotes the progression of hepatocellular carcino-ma ( HCC) .Loss of Smad4 and epithelial to mesenchymal tran-sition ( EMT ) may be the potential mechanisms how TGF-βtransforms from a tumor suppressor to a tumor promoter .Further studies on regulatory mechanism of TGF-βsignaling pathway are of great significance , which could provide new evidence for pre-venting and treating HCC .

Statins, hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors , are widely used as a class of lipid-lowering drugs in clinic. Recent studies have shown that the use of statins can be anti-inflammatory, anti-fibrosis and reduce the incidence of hepatocellular carcinoma (HCC), which may provide a new method for the preventive treatment of HCC. This article will review the current research progress of statins, including the clinical evidence, the molecular mechanisms of anti-inflammatory, anti-fibrosis and anti-tumor in liver.

Objective To investigate the effect of mytomycin C in the operation of dacryocystorhinostomy for curing lacrimal passage obstruction. Method Forty-one patients with traumatic lacrimal passage obstruction were divided into treatment group (n=21, 14 males and 7 females with an average age of 32) and control group. (n=20, 12 males and 8 females with an average age of 35). The patients in treatment group received 0.4mg/ml of mytomycin C when undergoing dacryocystorhinostomy, while the patients in control group received no medicine when undergoing the same operation. Lacrimal passage was cleaned with water after operation, and the operational effectiveness of dacryocystorhinostomy were compared between the treatment group and control group. Results Twenty-one eyes were cured in treatment group, and the cure rate reached 100%. While for the 20 eyes in control group, 17 eyes were cured, and the cure rate was 85%. There existed statistical significance between the two groups (P

The bystander effect(BE) plays an important role in the gene therapy of cancer by the herpes thymidine kinase/ganciclovir(HSV-TK/GCV) system.It enhances the therapeutic efficacy of this system.Up to now,the exact underlying mechanism of the bystander effect remains unclear.A large body of evidence has indicated a close correlation of the connexin expression and gap junction in the targeted cells to the bystander effect.Here the publications concerning the relationship of gap junction with the bystander effect in the HSV-TK/GCV treatment have been reviewed.The possible cell death signals that can be transferred through gap junction to induce the bystander effect are also discussed.