Objective To improve the quality and santdard of medical French bilingual teaching and promote the learning ability of the students in medical universities. Medthods Analogy between English and French was applied to the intervention of bilingual teaching in the clinical students who were learning medical French. The advantages and disadvantages were analyzed.Results The students could apply their prior English to medical French learning and make progress in both languages. A series problems were found during the practice:arrangement of teaching contents, lack of teaching materials and shortage of teaching staff. Conclusion Analogy between English and French is an effective teaching method in both foreign language teaching and bilingual teaching. But the expected teaching goals can be achieved only by formulating reasonable teaching contents and strategies and mproving teachers’ quality.

Objective:To investigate whether celecoxib(CXB), a specific COX-2 inhibitor,can inhibit the proliferation of cyst lining epithelial cells through blocking mitogen-activated protein kinase(MAPK) signal transduction pathway.Methods: Primarily cultured cells were treated with different concentrations of CXB(0,2.5?10~(-6),5?10~(-6),1?10~(-5),2?10~(-5),3?10~(-5),4?10~(-5),5?10~(-5)mol/L) and the proliferative status was evaluated by BrdU assay.The levels of vascular endothelial growth factor(VEGF) were measured by enzyme-linked immunosorbent assay(ELISA);the production of proliferating cell nuclear antigen(PCNA) and phosphoMAPK were measured by real-time reverse transcription-PCR assay;and the expression of PCNA,MAPK and phospho-MAPK protein was detected by Western blotting.Results: BrdU assay revealed that CXB inhibited cell growth in a concentration-dependent manner;the maximum inhibition rate([63.9?1.2]%) was found when cells were treated with 2?10~(-5) mol/L CXB for 24 h.VEGF secretion by cyst lining epithelial cell was reduced by CXB in a concentration and time-dependent manner.The mRNA and protein levels of PCNA,phospho-MAPK in CXBtreated group were lower than those in control group(with no CXB treatment).Conclusion: CXB can obviously inhibit the proliferation of cyst lining epithelial cell and the secretion of VEGF,which might be through interfering with the phosphorylation of MAPK and partly blocking MAPK signal transduction pathway.

Oral rehabilitation restores form and function and impacts on general health.Teeth provide a discriminating sense of touch and directional specificity for occlusal perception,management of food with mastication and swallowing,and awareness of its texture and hard-ness.Peripheral feedback for control of jaw muscles includes the enamel-dentine-pulp complex and mechanoreceptors in the periodontal tis-sues.The implications of feedback from periodontal and other intra-oral mechanoreceptors as well as changes in central representation are significant for function and adaptation to oral rehabilitation.With implants,in the absence of the periodontium and periodontal mechanore-ceptor feedback,fine motor control of mastication is reduced,but patients are still able to function adequately.Further,there is no signifi-cant difference in function with full-arch fixed prostheses on teeth in comparison with implants.Predictable implant outcomes depend on bone support.Optimum restoration design appears to be significant for bone remodelling and bone strains around implants with occlusal loading. Finite element analysis data confirmed load concentrations at the coronal bone around the upper section of the implant where bone loss is com-monly observed clinically.Load concentration increased with steeper cusp inclination and broader occlusal table and decreased with central fossa loading and narrower occlusal table size.It is recommended that occlusal design should follow a narrow occlusal table,with central fossa loading in intercuspal contact and low cusp inclination to minimise lateral loading in function and parafunction.Acknowledging these features should address potential problems associated with the occlusion in implant therapy.

Recurrence and metastasis are main causes ofsurgical treatment failure of non-small cell lung cancer.In prevention of non-small cell lung cancer recurrence and metastasis,Chinese medicine has achieved a certain effect. It has been proved by clinical use of Chinese patent drugs, compound modification based on syndrome differentiation, integrated traditional Chinese and western medicine treatment, and molecular mechanism of anti-recurrence and metastasis, though there are still some problems. This article reviews the recent clinical and experimental research status.

Aim: To investigate the mechanism of anti-proliferation, anti-migration and anti-angiogenic effects of tanshinone ⅡA. Methods: In this study, MTT, 2-D/3-D migration, tube formation, PCR, chick embryo chorioallan-toic membrane (CAM) were used to evaluate the anti-proliferation, anti-migration and anti-angiogenic effects of tanshinone ⅡA. Results: Tanshinone ⅡA significantly inhibited the proliferation of human breast cancer line MDA-MB-435 with an IC_(50) of 21 nmol/mL And it is showed that breast cancer cells migration was effectively prevented by tanshinone ⅡA at 5 and 6 nmol/mL in a wound healing assay and a transwell migration assay. In ad-dition, tanshinone ⅡA inhibited the tube formation of newborn cattle aortic endothelial cells( NCAECs) after 2 h co-incubation with MDA-MB-435. These effects were not due to the inhibition of NCAECs proliferation; because tanshinone ⅡA non-selectively inhibited NCAECs growth with an IC_(50) of 124 nmol/mL Tanshinone ⅡA showed dose-dependent inhibitory effects on mRNA expression of VEGF and two transcription factors (HIF-1α/c-Myc) . Tashinone ⅡA was also found to inhibit angiogenic in vivo in the CAM assay. Conclusion: These results suggest that tanshinone ⅡA may exert its anti-proliferation, anti-migration and anti-angiogenic effects through down-regu-lating two transcription factors and VEGF. These novel anti-proliferations, anti-migrations, anti-angiogenic activi-ties of tanshinone ⅡA are likely to contribute to its cancer chemopreventive and therapeutic potential, especially in the treatment of breast cancer.

Prostate cancer is one of the most common malignant tumor of male population in the West.Via binding to androgen response element in the genome and interacting with co-regulators,androgen receptor can participate in the development of prostate cancer and the convertion from androgen dependent prostate cancer to androgen independent prostate cancer.Chromatin immunoprecipitation ,coupled with PCR , chip,and high-throughput sequencing ,makes a huge progress in the study on the downstream target genes of androgen receptor and provide a new way to understand the molecular mechanisms of castration -resistant prostate cancer.

Based on the research project of the French language teaching reform in Kunming Medical College——the Application and Analogy of Modern Foreign Languages Pedagogy,the successes and disadvantages of the visual-audio-oral course were studied.The teaching reform's purpose and focal points were primarily introduced.Then,the successful experiences of academic period arrangement,teaching materials selection,in-class instruction and students' academic achievements were elaborated.Finally,by making a comparison of students' French language proficiency between the present experimental classes and the former ordinary classes,a few disadvantages of the reform were interpreted.

OBJECTIVE:To investigate outpatients' cognition(including knowledge,attitude and behavior)on adverse drug reactions(ADR),and to analyze the influential factors of ADR cognition.METHODS:An on-the-spot questionnaire survey was conducted in which a total of 488 outpatients sampled from our hospital from May to December in 2007 were investigated and the data analyzed statistically.RESULTS:The correct rate was 36.6% for the questions related to cognition on ADR.70.5% of the patients investigated had a poor cognition on ADR.The factors influencing patients' cognition on ADR included educational background,ADR experience,pharmacists' guidance on medication,source of medicine knowledge,occupation,doctors' guidance on medication,community ADR lecture,and gender.CONCLUSION:The outpatients have a poor cognition on ADR.Both doctors and pharmacists should offer guidance on medication and give lecture in community to inform patients the knowledge about rational administration and ADR.

Objective To observe the therapeutic efficacy of moxa smoke fumigation in promoting the wounds healing and improving the pain at dressing changes after perianal abscess surgery.Method A hundred eligible patients with perianal abscess were divided into a treatment group and a control group by the random number table, 50 cases in each group. The subjects all received dressing change from nurses of the Anorectal Department. In addition, the treatment group received moxa smoke fumigation at wounds for 30 min and the control group received microwave radiation at wounds for 30 min, both after dressing change, for a total of 14 times. The wounds-healed time, Visual Analogue Scale (VAS) scores on the day 1, 2, 3, 7, and 14 after the surgery, and Verbal Rating Scale (VRS) scores of the two groups were observed.ResultPatients in the treatment group took significantly shorter time to heal the wounds compared to those in the control group (P<0.05); the VAS score on the first day after the surgery in the treatment group was insignificantly different from that in the control group (P>0.05), while the scores in the treatment group on day 2, 3, 7 and 14 were significantly lower than those in the control group (P<0.05); the VRS scores on day 1, 2, 3, 7, and 14 in the treatmentgroup were significantly lower than those in the control group (P<0.05).Conclusion Moxa smoke fumigation can promote the healing of the wounds after perianal abscess surgery, reduce the pain brought by dressing change, and this analgesic effect is consistent.

Infiltrated immune cells and cytokines in the tumor microenvironment may play different functions that appear tightly related to clinical outcomes.Radiotherapy mainly kills tumor cells through radiobio-logical effect,meanwhile it can indirectly change tumor immunologic microenvironment,and has a local or dis-tant anti-tumor immunological effect cooperatively.Animal experiments and clinical trials of radiotherapy com-bined with immunotherapy display well applied prospects,but the mode of radiotherapy in combined treatment needs further research.