Asialoglycoprotein receptor(ASGPR) is a specific receptor of mammalian hepatocytes.Reduction in ASGPR concentration has been proven to appear in liver cirrhosis and liver cancer.By liver ASGPR scintigraphy with 99mTcGSA,some indexes such as HH15、LHL15、[R]_0、R_0 can be obtained,which is useful for the evaluation of liver function.When combining with the techniques of functional scintigraphy and single photon emission computed tomography(SPECT),it becomes possible to functionally simulate the extension of hepatic resection and predict to some extent postoperative outcomes related to liver function.It is still a new professional field internationally,and almost absent domestically.It could be an important tool for quantificational evaluation of the risk of liver surgery and help determining the surgical procedures.We have here,with some of our research experiences in this field,written a review of ASGPR scintigraphy.

Objective To investigate the therapeutic effect of paclitaxel plus oxaliplatin chemotherapy to the transplanted non-small cell lung cancer of nude mice and the effect to the apoptosis protein expression of PDCD5 and XIAP with mice model.Methods A tumor-bearing mice were randomly divided into blank group, normal saline group, oxaliplatin group, paclitaxel group, paclitaxel plus oxaliplatin group.The gene expression of PDCD5 and XIAP was assayed by real-time quantitative PCR(q-PCR).The apoptosis related PDCD5 and XIAP protein were detected by Western blot.Finally, the tumor weight of each group was measured for statistical analysis.ResultsThe mRNA expression of PDCD5 was highest and the gene expression of XIAP was lowest in paclitaxel plus oxaliplatin group(P<0.01).The expression of PDCD5 protein was highest and the expression of XIAP protein was lowest in paclitaxel plus oxaliplatin group (P<0.01).Finally, compare the tumor weight of each group, paclitaxel plus oxaliplatin group has the least mass(P<0.01).Conclusions Paclitaxel plus oxaliplatin group chemotherapy significantly increases PDCD5 expression and reduce XIAP expression.Meanwhile, paclitaxel plus oxaliplatin chemotherapy can significantly reduce the tumor weight of happened non-small cell lung cancer.

Objectieve:In order to get the photoacoustic (PA) image of micro-blood vessel deep inside biological tissue.Materials and Methods:A 532nm pulse laser with the repetition rate of 10Hz was used as the pumping source.A wide band unfocused needle ultrasound transducer was used to collect time-domain PA signal of the tissue-mimicking phantom by circular scan.The 2D optical absorption image was reconstructed by time-domain spherical back projection algorithm.The spatial resolution was measured by line-spread-function(LSF).Results:The experimental results demonstrated that the spatial resolution was 0.1 mm and the PA image of the micro-vascular network agreed well with the tissue-mimicking phantom.Conclusion:The proposed method is valuable for the diagnosis of early cancer inside tissue.

There is no unity in judgment of obesity at home and abroad.WHO considered that there should have different evaluation criteria from childhood below and above 10 years and recommended "weight for height" be used for children under the age of 10 and body mass index(BMI)for children aged 10 to 24 years old.International Obesity Task Organization(IOTF) recommended BMI be suitable for young children for judgment overweight and obesity.Both of them had the same BMI standards for overweight and obesity for 18-year-old,25 and 30 kg/m2,respectively.But the Working Group on Obesity of China(WGOC)developed a criterion which cut-offs in 18 years were lower than that of WHO and IOTF,24 and 28 kg/m2,respectively.The treatment of obesity in childhood was different from that in adults.Many methods used for adults such as surgical liposuction,slimming drugs,hunger therapies and fasting could not be appropriate for childhood.A combined treatment in childhood including behavior modification,diet adjustment and exercise was recognized domestically and internationally.

Objective:To improve the quality standard for Anweiyang capsules. Methods: TLC was used to identify Glycyrrhiza inflata Bat. Licochalcone A was determined by RP-HPLC. Using a C18 Column, the mobile phase consisted of acetonitrile-0. 1% phos-phoric acid(40:60), and the detection wavelength was at 376 nm. Results:The herb could be identified by TLC. For licochalcone A, the linear range was from 25. 563 to 1 533. 798 ng, and the average recovery was 99. 8%(n=9). Conclusion:The method is simple and accurate, which can be used to improve and control the quality of Anweiyang capsules.

Objective To explore the appearance of CT angiography(CTA)and magnetic resonance angiography (MRA)in persis-tent carotid-basilar artery anastomoses,and discuss its clinical significance.Methods 1 7 patients of persistent carotid-basilar artery anastomoses diagnosed by CT and MR angiography were retrospectively reviewed.10 patients were examined by craniocervical CTA, 7 patients were examined by cranial and cervical MRA,and 3 patients were examined by CTA and MRA.Results 10 patients had persistent trigeminal arteries (PTA).Based on Saltzman type:6 cases were Saltzman type Ⅰ,2 cases were Saltzman typeⅡ,and 2 cases were Saltzman type Ⅲ.1 case of 3 persistent hypoglossal arteries(PHA)originated from the right carotid artery,and 2 cases originated from the left external carotid artery.2 cases of 4 proatlantal intersegmental artery(PIA)were right ipsilateral,and 2 cases were left ipsilateral.1 case of PTA and 1 case of PHA associated with an aneurysm.6 cases of PTA,2 cases of PHA and 1 case of PIA complicated with ipsilateral vertebral arteries artopied or hypoplasia of the contralateral vertebral artery.Conclusion CTA and MRA can demonstrate clearly the course of persistent carotid-basilar artery anastomoses and its complicating intracranial coexisting abnormalities.Diagnosis of this anatomic variation may be helpful for providing reliable data to the guidance of surgery and interven-tional treatment.

Objective To get photoacoustic (PA) image of vascular structure inside mouse brain in vivo.Methods A 532nm pulsed laser was used as the pumping source to generate PA signal,and a wide-band PVDF unfocused ultrasound transducer was used to collect time-domain PA signal by circular scan.PA signal recorded at each scanning position was then de-noised by wavelets transform using soft-thresholding.The PA image of the mouse brain vessel was reconstructed by time-domain spherical back projection algorithm.Results PA image agreed well with the histological picture of mouse brain vessel.Conclusion The experimental result indicates the potential value of clinical application.

Objective To study the clinical efficacy of Danhong injection for the treatment of idiopathic pul-monary fibrosis.Methods 84 patients with idiopathic pulmonary fibrosis were randomized into the control group ( prednisone treatment) and the observation group ( based on the prednisone treatment, added the Danhong injec-tion),42 patients per group.The clinical efficacy,oxygen partial pressure and CO diffusing capacity,the TGF-β1 in the serum and pulmonary ventilation in the two groups were observed and compared after 6-week treatment. Results Compared with the control group, the total effective rate was significantly increased ( 92.9% vs 71.4%) in the observed group(P<0.05);compared with the control group,the oxygen partial pressure [(67.57 ±9.93) vs (51.74 ±9.21)]mmHg and CO diffusing capacity[(18.98 ±3.44) vs (15.83 ±3.06)]mL/(min· mmHg) were obviously increased in the observed group after treatment( P<0.05);compared with the control group,the content of TGF-β1 in the serum was significantly reduced [(1.15 ±0.13) vs (3.02 ±0.28)]μg/L and the pulmonary ventila-tion [(1.85 ±0.36) vs (1.69 ±0.30)]L was obviously increased in the observed group after treatment(P<0.05);compared with the control group,the incidence of adverse reactions was obviously reduced (4.8%vs 19.0%) in the observed group(P<0.05).Conclusion The treatment of Danhong injection for the idiopathic pulmonary fibrosis has the significant efficacy and high safety,can effectively correct th hypoxemia,significantly improve the lung function, which is worthy of clinical promotion.

Objective To explore the modified mesh in female pelvic floor reconstruction for pelvic organ prolapse and clinical effects of the application.Methods 78 patients with pelvic organ prolapse,line modified mesh pelvic floor reconstruction surgery(study group)and vaginal hysterectomy and vaginal repair of anterior and posterior wall(control group)treatment,clinical efficacy was compared.Results The mean operating time,blood loss,average body temperature,catheter indwelling time,residual urine volume,and postoperative hospital stay showed no significant difference(P＞0.05).No postoperative infection,vaginal hematoma,mesh erosion occurred.Two groups of patients before discharge degree of POP-Q points are 0°or Ⅰ degree,to cure the standard.Vaginal length of the control group was significantly shorter than after treatment(P＜0.05),while no significant change in the observation group(P＞ 0.05).Control group,the recurrence rate was significantly higher than the observation group(P＜0.05),while the observation group of sexual satisfaction was better than the control group(P＜0.05).Conclusion The modified mesh treatment of female pelvic floor reconstruction is an effective method of pelvic organ prolapse,the surgical curative effect is better,the recurrence rate is lower,worthy of clinical application.