Neonates with congenital Polycystic Kidney Disease (PKD) are often associated with multiple organ abnormalities
and result in poor prognosis. Renal Replacement Therapy (RRT) sometimes required to treat PKD patients with
declined renal function. Peritoneal dialysis (PD) widely used as RRT due to several advantages. However, PD installment in neonates had never been performed in Yogyakarta, Indonesia, due to lack of neonatal tenckhoff and
inaccuracy of dwelling scale. We present a neonate, preterm, with bilateral PKD and kidney failure, and needed
performed RRT. After considering all disadvantages we performed PD in this neonate. This report will elaborate on
all issues that ensued, and how to resolve it, to improve management kidney failure for neonates that requiring PD
in Yogyakarta, Indonesia.