Objective:To investigate the mechanism in growth inhibition of garcinia acid to kidney cancer cell lines ( RC-2 ) . Methods:RC-2 cells were cultured in vitro, and garcinia acid at various concentrations was co-cultured with RC-2 cells. The antipro-liferative activities were determined by CCK-8 assay, the percentage of apoptosis was determined by flow cytometry analysis, and the expression levels of Survivin and related proteins in Wnt3α/β-catenin signal pathway were measured using Western Blot analysis. Re-sults:After the treatment with garcinia acid for 24h and 48h, the proliferation of RC-2 cells was significantly suppressed by garcinia acid in a dose-dependent manner, and all garcinia acid groups had significantly higher apoptosis percentage of RC-2 cells than the con-trol group. In G0/G1 period, RC-2 cells reduced while increased in G2/M period, and in S period, the cells remained the same a-mount. The expression levels of Survivin, Wnt3α and β-catenin decreased in RC-2 cells after the treatment with garcinia acid. Con-clusion:Garcinia acid can inhibit the proliferation and promote the apoptosis of RC-2 cells, and the mechanism may be related with the inhibition of Wnt3α/β-catenin signal pathway and further decreasing the expression levels of Survivin.

Many voting activities such asThe Best Medical Workers put medical workers onto moral high ground,while medical dispute,medical anomie and other news pushed them to the abyss of criticism.These are all involved in the pan-moralization of medicine-related consensus of mass media.Taking specific opinion as example,this paper listed the pan-moralization characteristics including judging the complicated problems with ethical standard merely,evaluating behaviors of physicians and patients with idealistic principles,determining the whole moral outlook from the individuals,analyzed the reason of social emotional outbursts,traditional moral interference,media ethics anomie,and lack of public rationality,and finally proposes the strategies to avoid pan-moralization of medicine-related consensus from the micro and macro level.

Inflammasomes are molecular platforms built around several proteins ,composed of intracellular pattern-recognition receptors,the adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC)and caspase-1. The inflammasome was believed as the cellular machinery triggering the maturation of proinflammatory cytokines such as interleukin-1β(IL-1β)to engage innate immune defenses. Several types of inflammasomes have been identified ,and among them NLRP3 inflam?masome is currently the most fully characterized inflammasome. Recent studies showed that a variety of cardiovascular risk factors , including dyslipidemia,hypertension and kidney disease,hyperhomocysteinemia,obesity,diabetes and metabolic syndrome,can activate NLRP3 inflammasomes,process the maturation of proinflammatory cytokines IL-1βand IL-18,and promote atherosclerosis. The activation of NLRP3 inflammasomes was also associated with decreased stability of atherosclerotic plaque. These studies suggested an important role of NLRP3 inflammasomes in the pathogenesis of cardiovascular disease. Targeting NLRP3 inflammasome at the stage of its assembling or activation may be a novel strategy for prevention and treatment of cardiovascular disease.

ObjectiveTo observe the clinical efficacy of electroacupuncture plus magnetic resonance in treatingpostoperative gastroparesis syndrome.MethodPatients with postoperative gastroparesis syndrome were recruited and coded according to the onset time, and then randomized into a treatment group of 10 cases and a control group of 10 cases. The treatment group was intervened by electroacupuncture plus magnetic resonance, while the control group was by electroacupuncture. The recovery time of gastrointestinal motility and drainage volume of gastric fluid were observed after treatment.ResultThe drainage volume of gastric fluid was significantly reduced (P<0.05) and it took less time to recover the gastrointestinal motility in the treatment group;compared to the control group, it took a significantly shorter time to recover the gastrointestinal motility in the treatmentgroup (P<0.05); after 20-day treatment, the drainage volume of gastric fluid was markedly reduced in the treatment group (P<0.05). ConclusionElectroacupuncture plus magnetic resonance can produce a more significant therapeutic efficacy in treating postoperative gastroparesis syndrome thanelectroacupuncture alone.

Social media users increasingly participate in the health communication, which plays a positive role as well as causes ethical anomie. Health communication should comply with several ethical principles such as non-maleficence, preciseness and realism, kindness and benevolence, popular expression and applicability and so on. It is suggested that the media should use the principal force of the competent department, operating organiza-tion, user, and the public. Meanwhile, it should strengthen ethical responsibility and control of health communica-tion and jointly promote the healthy development by strengthening self-discipline consciousness of users, impro-ving the supervision efficiency of the platform, cultivating media literacy of the public, and raising cost of ethical anomie.

Contemporary international competition is the main aspect in development of science level and technology capaci?ty, and innovation ability, and the competition must rely on top talent. The graduate students ( including master′s and doctoral students) are the main reserve and source oftop talent. As a doctoral postgraduate tutor of Otolaryngology&Head and Neck Surger?y, I deliver some of personal views and opinions on this professional postgraduate education present situation and the conceives about the future. Based on some of my knowledge and understanding for progress and tendency of this professional research fields, I put for?ward some of aspects and contents which will be worth focused research and exploration for training objective nad requirements, charac?teristics and current situation, culture mode of Otolaryngology & Head and Neck Surgery postgraduate students.

Plastic and cosmetic surgery is an emerging disci-pline which can create beauty with medical intervention.It can be say that plastic and cosmetic surgery can combine medicine with aesthetics and art.Plastic surgeon is the angel of this perfect combination.In this paper, the author discusses how to be a qualified plastic surgeon to real-ize the combination of medical, aesthetics and art through more than 30 years clinical experience and teaching practice in plastic and cosmetic surgery.

In this paper, the characteristics of new media information dissemination are interpreted in detail, including the expression of liberalization, virus-disseminating, inclination of news entertainment, violence of pub-lic opinion and over-exposure of privacy. This article takes the immoral cases of medical news in recent years as examples, deeply analyzes the serious phenomena of medical news under new media environment, such as misrepr-esentation, loss of authority, moral loss of reputation, loss of social rationality and disclosure of public privacy.

In the circumstance of that the medical system reform follows to the principle of combination of government leading and market mechanism and in view of medical ethics boundary and stratification, this paper pointed out that whether the discussion and introspection of society or the doctors,medical decision-making should focus on the relationship between medical behavior and the patients′health interests, which is ensured by reasona-ble system. Decided by the current situation of medical decision -making stratification, layered construction of medical ethics is beneficial to that the medical behaviors gradually regress to the ethical value, while establishment of diagnosis and treatment norms is the ethical choice of current medical decision-making.

Objective To analyze the clinical features and significance of the samples which the expression of ANA is positive and the expression of anti‐ENA antibody is negative .Methods Detect ANA and anti‐ENA antibody of all the 297 samples by indi‐rect immunofluorescence method and biological chip technology ,repectively .And analyze the fluorescence karyotype of ANA posi‐tive specimens with double‐blind method .Screen the samples which anti‐ENA antibody express negative from ANA positive sam‐ples .Compare and analyze the fluorescent karyotype .Results Of all the 297 samples ,74 cases were positive for ANA ,the positive rate was 24 .9% (74/297) .The majority of patterns were speckled pattern (43 cases ,58 .1% ) ,cytoplasmic granular pattern (9 ca‐ses ,12 .2% ) ,and antibody to centromere antigen(9 cases ,12 .2% ) ,respectively .In 74 cases of ANA positive specimens ,ENA anti‐body the negative rate of ENA antibody is 17 .6% (13/74) .Of the 13 cases ,the most frequently occurred pattern was the speckled pattern(11 cases ,84 .6% ) ,the rate of cytoplasmic granular pattern and antibody to centromere antigen was 7 .7% (1/13) respec‐tively .Conclusion In the serum samples which express ANA positive and ENA antibody negative ,the rate of speckled pattern is significantly higher than the other patterns ,and far more than the rate of speckled pattern in the samples which express ENA anti‐body and ANA positive (52 .5% ) (chi‐square= 5 .018 ,P< 0 .05) ,with statistical significance .We consider the speckled pattern samples be in favour of discovering new antibodys of this kind of serum sample .