1.Nutritional evaluation of serum colloidal reactions. Especially Thymol turbidity test.
Masahide Imaki ; Tamotsu Miyoshi ; Takeshi Yoshimura
Journal of the Japanese Association of Rural Medicine 1985;34(2):117-121
The purpose of this study is to make clear comprehensive relationship between Thymol turbidity test values (TTT) and the dietary intakes of nutrients. The subjects of this study were 287 young healthy people in Tokushima prefecture.
The results of the survey were as follows:
1) In males, multiple regression analysis showed that variables which correlated best with the TTT values were dietary intakes of sugar energy and vegetable protein aged 30-49 years, and dietary intakes of animal fat and energy aged 50-69 years.
2) In females, multiple regression analysis showed that variables which correlated best with TTT values were dietary intakes of animal protein and vegetable fat aged 50 69 years, but there were no statistically significant correlation between TTT values and the dietary intakes of nutrients aged 30-49 years.
2.An epidemiological study on the fraction ratio of serum .GAMMA.-GTP(1) and nutrient intakes with the difference of somatotype.
Takeshi YOSHIMURA ; Tamotsu MIYOSHI ; Masahide IMAKI
Journal of the Japanese Association of Rural Medicine 1985;34(4):789-796
The purpose of the present paper is to explore the relationships between the activity and fraction ratio of serum γ-GTP and the dietary intake of nutrients through three groups (lean, normal and overweight) by Broca's index. Broca's index in each groups was under 89 for the lean group, from 90to 109 for the normal group and over 110 for the overweight group. The subjects of study were 249 young healthy men except alcoholic.
Results of the survey were as follows:
1) There were statistically significant correlation between serum total γ-GTP activity in normal group and vitamin C intake (P<0.05).
2) High negative correlations were observed between the fraction ratio of serum γ-GTP (1) and the vitamin B 1 intake (P<0.01), between the fraction ratio of serum γ-GTP (1) and vitamin C intake (P<0.01), and between the fraction ratio of serum γ-GTP (1) and the protein intake/kg of body weight (P<0.01) in the lean group. High negative correlations were observed between the fraction ratio of serum γ-GTP (1) and the protein intake (P<0.01), between the fraction ratio of serum y -GTP (1) and the vitamin B 1 intake (P<0.01), between the fraction ratio of serum γ-GTP (1) and vitamin C intake (P<0.01), and between the fraction ratio of serum γ-GTP (1) and the protein intake/kg of body weight (P<0.01) in the normal group. High negative correlation was observed between the fraction ratio of serum γ-GTP (1) and the vitamin C intake (P<0.01) in the overweight group.
3) Multiple regression analysis showed that the variables which correlated best with the fraction ratio of serum γ-GTP (1) were dietary intakes of the energy, the vitamin C and the protein intake/kg of body weight in the lean group. The fraction ratio of serum γ-GTP (1) related to the vitamin C intake and the protein intake/kg of body weight in the normal group. In the overweight group, the fraction ratio of serum γ-GTP (1) related to the vitamin C intake and the animal protein intake.
3.Epidemiological study on the relation of serum lactate dehydrogenase (LDH) isozymes and activity to protein intake in man.
Takeshi YOSHIMURA ; Tamotsu MIYOSHI ; Masahide IMAKI
Journal of the Japanese Association of Rural Medicine 1986;34(5):889-893
This paper reports the changes in the activity and isozyme pattern of serum LDH in healthy young men given a low protein diet (0.73-0.75/kg body weight; 40-50g/day) for 21 days.
Serum total LDH activity showed no significant change in eight healthy young volunteers who received low protein diet for 21 days. However, the percentages of LDH-5 and LDH-4 increased significantly (P<0.01) from basal levels of 5.9±2.3 and 7.1±1.4 to 10.6±2.9% and 10.1±0.9%, respectively on day 14.
These results suggest that measurements of the percentages of LDH-4 and LDH-5 isozymes can be used to evaluate the protein intake, but serum LDH activity cannot be used as an index of nutrition.
4.Study on the Blood Properties and Nutrient Intakes
Tamotsu Miyoshi ; Masahide Imaki ; Takeshi Yoshimura
Journal of the Japanese Association of Rural Medicine 1984;33(1):46-49
The purpose of this study is to make clear a comprehensive relationship between two groups of blood properties and nutrient intakes. The first group of measurement include hemoglobin contents, hematocrits and blood specific gravity and the second group of measurements includ energy, protein, fat, carbohydorate, vitamin A, B1, B2, C, animal protein, animal fat, iron, animal iron and age.
These figures are taken from the epidemiological survey of Tokushima prefecture, including 301 males and 379 females, investigated from 1975 to 1980.
Appling the canonical correlation analysis, we found the following results.
1) In male, only canonical correlations were statistically significant. The hematocrit related strongly to carbohydorate, animal protein, fat intakes and age.
2) In female, only canonical correlations were statisticall significant. Both hemoglobin contents and blood specific gravity effected carbohydorate and energy intakes.
5.Study on the serum enzyme activity and nutrient intakes. Application of canonical correlation analysis.
Masahide Imaki ; Tamotsu Miyoshi ; Masanobu Fujii ; Takamichi Tamura ; Takeshi Yoshimura
Journal of the Japanese Association of Rural Medicine 1985;33(5):892-896
The purpose of this study is to make clear a comprehensive relationship between two groups of serum enzyme activity and nutrient intakes. The first group of measurement include serum GOT, GPT, ALP activity and the second group of measurements include protein, fat, carbohydorate, vitamin A, B1, B2, C, animal protein, animal fat, age, and weight.
These figures are taken from the epidemiological survey of Tokushima prefecture, including 252 males and 383 females, investigated from 1975 to 1980.
Appling the canonical correlation analysis, we found the following results.
1) In male, only two canonical correlations were statistically significant. The serum GOT and GPT activity related to body weight, further serum GOT activity was effected quality of food intakes.
2) In Female, three canonical correlations were statistically significant. Both serum GOT and GPT activity related to protein intakes. High correlations were observed between serum GOT activty and vitamin B1, between serum GPT activity and vitamin C, between serum ALP activity and age.
6.A study on regional environmental hygiene in view of complaints about public nuisances in rural district.
Yoshiharu HORI ; Tamotsu MIYOSHI ; Masahide IMAKI ; Takeshi YOSHIMURA
Journal of the Japanese Association of Rural Medicine 1987;36(1):13-21
This survey was conducted in a local city, Tokushima for its 23 administrative sections, which were classified into rural, non-rural and mixed districts based on the data related to agriculture. Complaints of public nuisances in these districts have been examined and the following findings have been obtained.
1. Complaints about water pollution and offensive odor in the rural district and those about offensive odor and noise in the mixed district have been raised more often, respectively. While, in the non-rural district more complaints about noise have been raised. Thus, it is recognized that possible pollution phenomena vary depending on regional patterns.
2. In time-serial comparison between the first half (1977-1980) and the second half (1981-1984) of survey period, it is found that total complaints of public nuisances have been reduced and the complaints in the rural district have been increased for all the types excepting dust. Therefore, it is suggested that regional environment in suburban farm villages has been deteriorating.
7.Studies on the variation of human serum lipids by intaking lentinus edodes for the preservation of health in rural areas.
Takeo NAKAMURA ; Tamotsu MIYOSHI ; Masahide IMAKI ; Yuki YAMADA ; Takeshi YOSHIMURA
Journal of the Japanese Association of Rural Medicine 1987;36(1):33-38
For the preservation of health in rural areas, this paper reports on the variation of human serum lipids by intaking lentinus edodes.
Serum lipids levels showed no significant change by intaking lentinus edodes that amounts of 20, 40 and 60g per day each for 5 days. From data of correlationship between serum lipid levels and nutrition intake of experimental diet, it was recognized that high-density-lipoprotein cholesterol level was directly proportional to carbohydrate-fat ratio significantly (p< 0.02), and was inversely proportional to fat intake, fat-protein ratio and carbohydrate-protein ratio significantly (p< 0.05), respectively. Triglycerides level was inversely proportional to protein intake significantly (p< 0.05).
These results concluded that the decrease of serum cholesterol level by intaking of lentinus edodes in healthy young men whose serum cholesterol levels were in normal range was not recognized.
8.Relationship between the activity of serum lactate dehydrogenase(LDH) and serum vitamin C in Japanese men and women in their middle and old age.
Masahide IMAKI ; Tamotsu MIYOSHI ; Takeshi YOSHIMURA ; Seiki TANADA ; Kazuoki MATSUMOTO
Journal of the Japanese Association of Rural Medicine 1988;37(2):87-91
The effects of the serum vitamin C levels on the activity and isozyme pattern of serum lactate dehydrogenase (LDH) in males and females in their middle and old age were examined.
There was no siginificant correlation among the total serum, LDH activity and serum vitamin C levels in the 87 male and 83 female ranging from 45 to 84 years of age. However, high inverse correlations were found among the percentage of LDH-4 and LDH-5 and serum vitamin C levels all of age groups (45-59 years of age group, 60-69 years of age group and over 70 years of age group) of males and females.
These results suggest that the percentage of LDH-4 and LDH-5 are influenced by the vitamin C intake in males and females in their middle and old age.
9.Relationship between SGOT/SGPT ratio and energy intakes.
Masahide IMAKI ; Tamotsu MIYOSHI ; Takeshi YOSHIMURA ; Tatsumi TOMIYAY ; Yoshiharu HORI ; Takeo NAKAMURA
Journal of the Japanese Association of Rural Medicine 1987;35(5):887-890
Relationship between SGOT/SGPT ratio and energy intake were investigated in 1030 subjects (373 males, 657 females). These figures were taken from epidemiological survey of the Tokushima prefecture from 1975 to 1980.
The results of the survey were as follows.
1) Energy intakes in reversal group (SGOT/SGPT <1) was higher than that in nromal group (SGOT/SGPT >1).
2) Body weight in reversal group was higher than that in normal group except young woman (18-39 years).
3) Incidence of reversal of SGOT/SGPT ratio showed increasing values as energy intakes levels increased.
It is possible to conclude from the results that SGOT/SGPT ratio was affected by energy intakes.
10.Efficacy of once-weekly and twice-weekly injections of teriparatide by patient characteristics: A post hoc analysis of the TWICE study
Toshitsugu SUGIMOTO ; Takeshi YOSHIMURA ; Toyonobu UZAWA
Osteoporosis and Sarcopenia 2021;7(1):11-16
Objectives:
To assess differences in efficacy of a 28.2-μg teriparatide formulation for twice-weekly use (2/W-TPTD) by patient characteristics.
Methods:
A post hoc analysis was performed using data from a multicenter, randomized, double-blind, double-dummy, non-inferiority trial (TWICE study) conducted in Japan comparing the efficacies of once-weekly and twice-weekly injections of teriparatide (TPTD). Specifically, a stratified analysis of percentage changes from baseline was performed using the final data on lumbar spine bone mineral density (BMD) after a 48-week treatment period (n = 251, 2/W-TPTD; n = 239, a 56.5-μg teriparatide formulation for once-weekly use [1/W-TPTD]).
Results:
Across all subgroups defined by patient characteristics that included 9 or more subjects, the lumbar spine BMD increased significantly in both groups. In the 2/W-TPTD group, the percentage change was significantly higher in subjects with no non-vertebral fractures without large external force occurring at or after age 50 years versus those with such fractures. The lower the stratification in baseline lumbar spine BMD, total hip BMD, or femoral neck BMD, the greater was the percentage change.
Conclusions
Whereas all subgroups can expect a significant improvement in lumbar spine BMD, there were some patient characteristics that affected the percentage increase in BMD.