1.Inattention Behavioral Assessment conducted by the Family at Home : Validity of BAAD (Behavioral Assessment of Attentional Disturbance)
Minoru Toyokura ; Takashi Sugawara ; Tomomi Hayashi ; Youko Nishimura ; Rie Murayama
The Japanese Journal of Rehabilitation Medicine 2009;46(5):306-311
Attentional disturbance following brain damage is usually evaluated by several neuropsychological tests. In a rehabilitation setting, however, the primary concern is not task performance, but rather functional real-world behavior. To address this requirement, a new assessment system for attentional behavior, BAAD (Behavioral Assessment of Attentional Disturbance), has been developed. This assessment is generally completed by the patient's therapist (occupational therapist, OT) during therapy. The aim of this study was to investigate whether BAAD completed by the family at home (BAAD-FM) yields results that are comparable to BAAD completed by an OT during occupational therapy (BAAD-OT). The subjects were 53 patients with brain damage. BAAD consists of six items thought to be associated with attentional behaviors. Each item is rated (0 to 3) based on the frequency with which the problem behaviors appeared during daily living at home and daily sessions of occupational therapy. The intraclass-correlation coefficient of the total score between BAAD-FM and BAAD-OT was 0.89. The mean (SD) values of the total scores were 3.7 (3.7) and 3.7 (3.6), respectively. Similarly, there were no significant differences in any of the item scores between BAAD-FM and BAAD-OT. The coincidence rate between the two BAAD tests on an item-by-item basis was over 64% for all items but one (43%). In conclusion, the total BAAD-FM score seemed comparable to the total BAAD-OT score and valuable for detecting attentional disturbance.
2.Questionnaire survey on infection control and prevention education in acupuncture schools
Masaaki SUGAWARA ; Hiroyoshi KOBAYASHI ; Takashi OKUBO ; Tomomi SAKAI
Journal of the Japan Society of Acupuncture and Moxibustion 2011;61(3):226-237
[Objective]We performed a questionnaire for the purpose of investigating the present conditions of infection control education in Japanese acupuncture schools and to discuss the problems.
[Methods]We conducted a postal survey by sending out questionnaires to 153acupuncture schools in Japan from December 2008 to March 2009.
[Results]Replies were obtained from 69.9%of the schools (107 out of 153schools). In their responses, 65%of the schools taught hand-washing with soap and alcohol-based hand rub as methods of hand hygiene. Moreover 58%of the schools used only single use needles (SUNs), 40%used both reusable and single use needles, and 2%used only reusable needles. However, single use was observed only at 25%of the schools that introduced SUNs.
Furthermore, we inquired whether the students were taught to use sterilized gloves and finger cots. The results illustrated that a proportion of schools provided the instruction;the proportion of constant instruction was 17%, that of the instructor's option was 35%, that of no requisite was 48%.
[Conclusion]From the above-mentioned results, it became clear that the direction for use of SUNs was not instructed adequately. In addition, this aseptic technique for puncture is not yet standardized in the school's education. It is necessary to realize the measures based on evidence and to employ them in educational programs at acupuncture schools.
3.Changes in serum immunogloblin levels and neutrophilic phagocytosis after exercise.
TAKASHI KUMAE ; KAZUO SUGAWARA ; KAZUHIKO MACHIDA ; AKIRA SHIMAOKA
Japanese Journal of Physical Fitness and Sports Medicine 1987;36(2):61-71
This paper is intended to give the information we need about personal reactivity to transient loads for the object of estimating human physical fitness. For this purpose, both serum immunoglobulin levels and neutrophilic phagocytosis were assayed as indices to self-defense activities.
To determine the later described reproducibility of experimental results, two independent experiments were made on two different groups -one consisting of twelve and the other of fourteen male voluntary students of our college- exercised in the playgroud. The serum levels of three immunoglobulins (IgG, IgA and IgM) and two complements (C3 and C4), prior to and immediately after exercise, were compared with each other. They rose without exception after exercise.
Paired T-test revealed that in the group of twelve students, rises in IgG, IgA, C3, α-1-antitrypsin and transferrin were significant at P<0.1%, 5%, 5%, 5% and 0.1%, and in the group of fourteen rises in IgG, IgA, IgM, C 3, C 4, α-1-antitrypsin and transferrin were significant at P<1%, 0.1%, 1%, 0.1%, 0.1%, 0.1% and 0.1%, respectively.
In the meantime, the neutrophilic phagocytosis (%) was significantly decreased immediately after exercise in both groups (P-<1% and P-<0.1% respectively) .
4.Effect of training on physical exersice-induced changes in non-specific humoral immunity.
TAKASHI KUMAE ; SHIGEYOSHI KURAKAKE ; KAZUHIKO MACHIDA ; KAZUO SUGAWARA
Japanese Journal of Physical Fitness and Sports Medicine 1994;43(1):75-83
Although it is generally thought that habitual exercise protects an individual from infections, few careful scientific studies have been conducted. To clarify the influences of physical training on non-specific humoral immunity, both serum opsonic activity, which is a more direct indicator for the strength of non-specific humoral immunity to infections, and serum immunoglobulin and complement levels of 18 healthy male volunteers were assayed before and after a 10-week of training as indices of immuno defense.
The serum levels of three immunoglobulins (IgG, IgA and 1gM) and one complement (C3) were compared prior to and immediately after exercise both before and after training. Paired t-test revealed that before training exercise-induced increases in IgG and C 3 were significant and after training increases in IgG, IgA, IgM and C 3 were significant. But baseline (prior to exercise) levels of these immunoglobulins and complement were significantly suppressed during the training period.
Serum opsonic activity was compared with each other in the same way as serum protein levels. The noutrophilic chemiluminescence Peak Height (PH), which is one of the indicators of serum opsonic activity, was significantly decreased immediately after exercise at the beginning stage of the training. After the training period, serum opsonic activity showed no noteworthy exercise-induced variations and baseline levels were slightly increased during the training period.
These findings suggest that resistance and reactivity to the physical stress are improved and the non-specific humoral immunity, self-defense ability against infections, is considered to be improved by the training.
5.EFFECT OF PHYSICL ACTIVITY ON SYSTOLIC BLOOD PRESSURE IN ELDERLY HUMANS
TAKUMI TANABE ; SEIJI MAEDA ; JUN SUGAWARA ; TAKESHI OTSUKI ; TAKASHI MIYAUCHI ; SHINYA KUNO ; RYUICHI AJISAKA ; MITSUO MATSUDA
Japanese Journal of Physical Fitness and Sports Medicine 2003;52(Supplement):167-176
Arterial compliance progressively decreases with aging. This aging-induced reduction of arterial compliance causes an increase of systolic blood pressure (SBP), whereas regular exercise increases arterial compliance. We hypothesized that an increase in daily physical activity (DPA) produces a beneficial effect on systemic arterial compliance (SAC ; an index of central arterial compliance) and this phenomenon could decrease SBP in the elderly. We investigated the relationship among DPA, SAC, SBP, diastolic blood pressure (DBP), and some other risk factors for cardiovascular and/or cerebrovascular events (total cholesterol, HDL-cholesterol, and HOMA-R) cross-sectionally in 127 elderly persons (42 male, 85 female : aged 74±4 years) . The DPA was estimated by expended calories using an accelerometer. The SAC was calculated from a finger pulse pressure waveform recorded by using PORTAPRES ; and stroke volume obtained from the same pressure waveform based on the volume-clump method. The analyses demonstrated that SBP was directly and decreasingly affected by SAC, and that DPA had an increasing effect on SAC. Furthermore, SBP was directly and increasingly affected by DBP, and DBP was directly and decreasingly affected by both SAC and DPA. Therefore, it is considered that DPA may have suppressive effects on the rise of SBP through the indirect effects of changing SAC and DBP. These findings suggest that an increase in DPA could improve the age-induced reduction of arterial compliance and rise of SBP in elderly humans.
6.The Unique Correlation between Anti-Mutagenicity of Human Saliva and Change in Body Weight
Masahiro TODA ; Kanehisa MORIMOTO ; Sei-ichi NAKAMURA ; Takashi UMEDA ; Shigeyuki NAKAJI ; Kazuo SUGAWARA
Environmental Health and Preventive Medicine 2001;6(2):82-87
The purpose of this study was to investigate the effect of weight reduction on the anti-mutagenicity of human saliva. Subjects were 16 male college judo players. The anti-mutagenicity of the saliva was measured using the umu test. There was an inhibiting effect of the saliva on the mutagenicity of AF-2. However, a modifying effect of the saliva on Trp-P-1 was not observed. On the day before a competition and 7 days after the competition, the inhibiting capacity of the saliva for the mutagenicity of AF-2 decreased and increased in two non-weight reduction and two weight reduction groups, respectively. However, on the day before the competition, the changed body weights (r=−0.77, p<0.01) and BMI (r=−0.77, p<0.01) were significantly correlated with that of the inhibiting capacity of the saliva for the mutagenicity of AF-2. In addition, the BMI at 20 days before the competition was not significantly but markedly correlated with it (r=0.50, p=0.057). At 7 days after the competition, however, these correlations were not found. These findings suggest a unique correlation between the anti-mutagenicity of human saliva and body weight or BMI.
Saliva
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competition
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Human
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Body Weight
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g <3>
7.The Effect of the Weight Reduction on the Salivary Cortisol Levels of Judo Players
Masahiro TODA ; Kanehisa MORIMOTO ; Sanae FUKUDA ; Takashi UMEDA ; Shigeyuki NAKAJI ; Kazuo SUGAWARA
Environmental Health and Preventive Medicine 2001;6(2):113-116
The purpose of this study was to investigate the effect of weight reduction prior to a competition on the salivary cortisol level for first-rate judo players. Subjects were divided into three groups by the weight reduction rate. On the day before the competition, the cortisol levels of the low- and high-weight reduction group showed a tendency to decrease and were significantly lower than that of the non-weight reduction group (p<0.05). However, with regard to the change in the stress indices, there was a difference between the high- and low-weight reduction groups. In the high-weight reduction group alone, there was a significant increase in the stress indices on the day before the competition (p<0.05). These findings suggest that the HPA axis is affected during the relatively early stage of weight reduction and mental stress is increased at the higher weight reduction rate.
Reduction (chemical)
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Weight
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competition
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Salivary
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Levels
8.Physical Load of Labors upon the Farmers Engaged in Raising Silk Worms
Masashi Nakamura ; Koichi Yukawa ; Humio Hirata ; Takashi Ikeda ; Yumi Ishihara ; Masashi Sugawara ; Haruaki Chirifu ; Kazue Morimoto ; Nobuko Noda ; Mutsuyoshi Tsuchimoto ; Kazuo Sugawara
Journal of the Japanese Association of Rural Medicine 1981;30(4):763-772
Investigation on the working time, energy expenditure and fatigue were carried out for members of three families engaged principally in raising silk worms.
Group examinations of physical conditions and blood constituents and survey of nutritional intake were performed on the residents, including the above families, in a community in Fukueisland, Nagasaki-prefecture.
The results were as follows;
1) The average values of energy expenditure on a most busy day in a raising period of silk worm calculated to be 3150 kcal (max. 3500 kcal) for males, 2340 kcal (max. 2890 kcal) for females of the above three families. Their working times on this day were about 14 hours.
2) The physical fatigue of the subjects was estimated by means of Fliker frequency, near point and threshold of patellar reflex. Remarkable changes of these values were found, suggesting the heavy physical load of the raising works, and the changes were more remarkable in olders and females than in youngers and males.
3) Donaggio's reaction and Na/K in the first urine of morning were investigated at an interval of five days during one period of silk worm raising.
The Donaggio's reaction values were increased about two times higher in the latter term, on the other hand Na/K dropped in the former term of the period.
4) The group examinations of the inhabitants in the community showed that the body fat of silk raising farmers were fewer than that of the farmers engaged in other kinds of farming reported by the present authors.
Blood values (Ht, Hb and TP) of them in 1975 were lower than in 1974, because one more raising period was added and so the physical load of them might be greater in '75 than in '74.
5) The nutritional intakes of silk raising farmers were almost as same as these of the farmers in other districts.
9.Relationship between Clozapine-Induced Electroencephalogram Abnormalities and Serum Concentration of Clozapine in Japanese Patients with Treatment-Resistant Schizophrenia
Yuka Sugawara KIKUCHI ; Takashi KANBAYASHI ; Tetsuo SHIMIZU
Psychiatry Investigation 2019;16(4):279-284
OBJECTIVE: The objective of this study was to investigate the relationship between the serum concentration of clozapine (C-CLZ), N-desmethylclozapine (N-CLZ) and the daily dose of CLZ (D-CLZ), and the relationships among CLZ and electroencephalogram (EEG) abnormalities. METHODS: Twenty-eight patients were recruited to this study, but 8 patients were excluded because clozapine was discontinued before the post-treatment measurement of EEG or C-CLZ. Ultimately, 20 patients (6 men, 14 women) with an average age of 36 years were enrolled. The subjects were divided into EEG normal and abnormal groups. C-CLZ and N-CLZ were measured at 4, 12, 26, and 52 weeks after initiating CLZ administration. RESULTS: All patients had normal baseline EEG signals, and 8 patients showed EEG abnormalities later. There were significant correlations between C-CLZ and D-CLZ, and between N-CLZ and D-CLZ. The C-CLZ/D-CLZ, N-CLZ/D-CLZ, and C-CLZ/N-CLZ ratio were not significantly different between the EEG normal and EEG abnormal groups. The EEG abnormal group had significant higher proportion of patients with high intra-individual variability in their C-CLZ/D-CLZ ratio. CONCLUSION: There is no relationship between C-CLZ and EEG abnormalities. However, patients with high intra-individual variability in their C-CLZ/D-CLZ ratio had greater possibility of exhibiting EEG abnormalities.
Asian Continental Ancestry Group
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Clozapine
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Electroencephalography
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Humans
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Male
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Schizophrenia