Both westernization of diet and lifestyle habits and chronic inactivity have accelerated the obese population in Japan. Obesity is defined as being a condition in which the excessive energy is stored in the body as fat. Irrespective of organs and tissues, excessive fat accumulation impairs their structure and function, that is, ectopic adiposis. These days, the rapid increase in the number of adult people with abnormal liver function associated with obesity is largely attributed to an increase in the incidence of non-alcoholic fatty liver disease (NAFLD), a chronic liver disease accompanying fat accumulation. In Japan, about 30% of obese people suffer from NAFLD. About 10% of NAFLD progresses to non-alcoholic steatohepatitis (NASH). NASH is a progressive disease leading to liver cirrhosis. Any treatment with consensus other than diet restriction and exercise training is ineffective for the prevention of onset and progression of NAFLD. The important thing is a practice of suitable amounts of exercise, since it maintains muscle volume, increases the utilization of glucose, and attenuates insulin resistance, all of which may contribute to a decease in hepatic fat accumulation levels. It may be of great significance to practice exercise training for patients with chronic liver disease for improving the liver pathophysiology of NAFLD. In this review, first, the onset mechanism for NAFLD in obese subjects is summarized; second, beneficial effects of exercise on liver pathophysiology of NAFLD are reviewed based on the data from a weight reduction program consisting of dietary restriction plus aerobic exercise; and finally, medical support of obese patients with NAFLD in Tsukuba University Hospital are introduced.

A 65-year-old man was referred to our service complaining of intermittent claudication of his left leg. During preoperative examinations, he was found to have bilateral isolated internal iliac artery aneurysms. As it was strongly suspected that ischemic colitis or gluteal ischemia would be caused if his bilateral internal iliac arteries were ligated during aneurysm surgery, his right internal iliac artery was reconstructed using a prosthetic graft. His postoperative course was uneventful. As aneurysm of the internal iliac artery is rare, there are few reports about reconstruction of the internal iliac artery. Technical details and pitfalls of internal iliac artery aneurysm surgery were discussed.