The primary purpose of this study was to investigate whether the baseball pitchers have asymmetric characteristics of muscle thickness (MT) in upper extremities, trunk, and lower extremities because of repetitive pitching. The secondary purpose of this study was to investigate the relationship between MT and ball speed. Twenty-six college baseball pitchers participated in this study. Twenty-six sites were selected to quantify the asymmetric characteristics of MT. The MT was measured by a B-mode ultrasound. The ball speed, measured by a radar gun, was used to quantify the pitching performance. The MT of forearm, subscapula, and chest in dominant side (pitching side) were significantly greater than those in nondominant side, and the MT of abdomen, lateral abdomen, and anterior thigh in nondominant side were significantly greater than those in dominant side. On the other hand, the MT of forearm in both sides and the MT of lateral abdomen in dominant side were significantly and positively correlated with ball speed. These results suggest that asymmetric muscle thickness in upper extremity, trunk, and lower extremity in baseball pitchers resulted from repetitive pitching, and the MT of forearm and lateral abdomen are related to the ball speed.

Hamstring muscles form a multi-articular muscle group that crosses the hip and knee joints. It has been said that the imbalance in the hamstrings:quadriceps strength ratio (H:Q ratio) due to weaker hamstring muscles results in an increased susceptibility to hamstring strains and anterior cruciate ligament injuries. Four different hamstrings trainings, Hip Lift (HL), Single-leg Deadlift (DL), Leg Curl (LC), and Nordic Hamstrings (NH), were conducted and compared in the effect on conventional H:Q ratio. After the training of two months, significant increase of hip extension torque and H:Q ratios in the hip joint were found in the DL group, and significant increase of knee flexion torque and H:Q ratios in the knee joint were found in the LC group (P < 0.05). As a conclusion, DL and LC training could be practical for hamstrings injury prevention.

A 54-year-old man, involved in a motor vehicle collision, was transferred to our hospital. He was hemodynamically stable. A CT scan of the chest demonstrated traumatic aortic dissection and a mediastinal hematoma with hemothorax of left side. Endovascular aortic repair using a homemade device was immediately performed, and a completion angiogram revealed complete exclusion of the aortic injury, with no extravasation. A postoperative CT scan revealed satisfactory placement of the endograft, with no extravasation. The patient was discharged on the 13th postoperative day. Endovascular aortic repair was useful and minimally invasive therapy in this case for the treatment of traumatic thoracic aortic rupture.

A 79-year-old man was transferred to our hospital because of massive hematemesis. Contrast-enhanced CT scan demonstrated extravasation of contrast medium into the jejunum. Therefore, we diagnosed primary aortoenteric fistula and performed an emergency operation. At surgical exploration, the jejunum was closely adherent to the normal-sized aorta. The fistula was present between the anterior wall of the aorta and the jejunum. Operative reconstruction was performed with in-situ grafting and a pedicled omentum flap was placed around the graft. The postoperative course was uneventful, and there has been no evidence of infection during the follow-up period of 1 year.

We here report two cases of successfully treated secondary aorto or iliac arterial-enteric fistula after graft replacement for abdominal aortic aneurysm. Case 1: A 80-year-old man who complained massive anal bleeding had undergone Y-shaped graft replacement for abdominal aortic aneurysm 22 years previously. Computed tomography demonstrated an aneurysm and hematoma formation at the anastomosis of the right graft limb and the right common iliac artery. Preoperative angiography showed no leak of contrast medium at the distal anastomosis of the right graft limb. A presumptive diagnosis of secondary iliac arterial enteric fistula was made, therefore, we performed an emergency operation. Extra-anatomic bypass preceded the removal of the right graft limb, partial resection and direct reconstruction of the ileum by the retroperitoneal approach. His postoperative course was uneventful and he was discharged on the 19th postoperative day. Case 2: A 77-year-old man who had received Y-shaped graft replacement of an abdominal aortic aneurysm 9 years previously was transferred to our hospital because of sudden onset epigastralgia and massive hematemesis. Gastroduodenoscopy revealed a fresh blood clot in the third portion of the duodenum where it was compressed by for surrounding pulsatile environment. An emergency computed tomography showed aneurysm formation without extravasation of contrast medium in the duodenum at the proximal anastomosis of the prosthetic graft. A secondary aortoenteric fistula was highly suspected and emergency operation was performed. Extra-anatomic bypass preceded the removal of the graft body, infrarenal aortic stump closure, duodenal closure and the greater omentum was used to fill defects. He underwent successful staged abdominal wall closure due to bowel edema making primary closure impossible. His postoperative course was uneventful and he was discharged on the 26th postoperative day.

Objective: The Japanese risk management plan (RMP) contains the risk minimization action plans for important potential risks of drugs.  One of the basic risk minimization action plans is reminding on package insert; however, we found that some potential risks were not described in package inserts.  In this study, we investigated the description of potential risks on package inserts.
Design: Document analysis.
Methods: We collected all posted RMP documents and the package inserts of corresponding products from the Pharmaceutical and Medical Devices Agency website on January 31, 2015 and investigated the risk minimization action plans of important potential risk items and whether the items had been described in each package insert.
Results: Of 268 important potential risk items in 81 products, 56 items were not described on package insert.  The major reason for not including the risk items on the package insert was “causality was not indicated sufficiently” and some items had no written reason.
Conclusion: About 20% of important potential risks are not described in package inserts.  Because most post-marketing pharmacovigilance plans depend on spontaneous reporting by healthcare personnel, description on package insert, the most frequently referred drug information resource, should be considered.

Recoarctation, systemic hypertension, aortic aneurysm and intracranial aneurysm are generally observed within a certain period after the surgical procedure for aortic coarctation, which is known as a systemic diseases caused by not only morphological abnormalities but also arterial functional abnormalities of artery. Here, we report a case who showed complications of recoarctation, hypertension and subarachnoid hemorrhage after surgery for aortic coarctation. A 17-year-old boy originally presented to our hospital with upper extremity systemic hypertension. Recoarctation after surgery for aortic coarctation was diagnosed in his childhood, following which hypertension was followed while he received continuous treatment with anti-hypertensive drugs. He was hospitalized with sudden headache and loss of consciousness. Since subarachnoid hemorrhage was diagnosed by computed tomography, clipping of intracranial aneurysms was performed. After the clipping procedure, he underwent percutaneous intravascular stenting angioplasty. However, the pressure gradient remained and sufficient dilatation was not obtained because of the hypoplastic anatomical distal aortic arch (from the left internal carotid artery to the site of recoarctation) due to the development of collateral circulation with rib notch. At age 21, extra-anatomical bypass (from the ascending aorta to the descending aorta) was performed because of persistent upper extremity systemic hypertension. However, systemic hypertension continued to require antihypertensive medication.

We reporte the initial results of open stent-grafting (OSG) applied with a Matsui-Kitamura (MK) stent in the treatment of thoracic aortic aneurysm (TAA). From August 2005 to March 2011, OSG for TAA was applied in 35 cases (male/female, 29/6, 58∼86 years old, mean age 71). During deep hypothermic circulatory arrest with antegrade selective cerebral perfusion, the stent graft was delivered through the transected proximal aortic arch, followed by arch replacement with a 4-branched prosthesis. Concomitant procedures included 1 coronary artery bypass graft, 1 mitral valve replacement and 2 pacemaker implantations. Operative mortality within 30 days was 5.7% (respiratory failure in 1 and ischemic enteritis in 1). There was 1 in-hospital death due to brain stem infarction. Perioperative morbidity included 2 (5.7%) stroke, 5 (14.3%) spinal cord injuries (paraplegia in 1, paraparesis in 1 and transient paraparesis in 3) , and 1 (2.9%) temporary hemodialysis. Ten patients (28.6%) were intubated for more than 72 h. There was no complication with the graft-related incident. These initial results suggested the OSG method applied with a MK stent is a useful surgical procedure for the treatment of TAA.

Objective : We examined the utility of distal perfusion (DP) in open stent grafting (OSG) for the treatment of thoracic aortic aneurysm. Methods : Fifty patients who underwent OSG were categorized into two groups (the Non-DP group and the DP group) based on the presence or absence of distal perfusion in OSG. There was no statistically significant difference between the two groups with regard to patient characteristics. Results : There was no statistically significant difference between the two groups with regard to operation time, but, cardiopulmonary bypass time (178±22 min vs. 193±18 min ; p <0.01) and aortic cross clamp time (84±23 min vs. 106±19 min ; p<0.01) were significantly longer in the DP group. Lower-body circulatory arrest time (46±11 min vs. 20±5 min ; p<0.001) was significantly longer in the Non-DP group. Postoperative paraplegia and paraparesis occurred in one case each in the Non-DP group, whereas permanent spinal cord ischemia did not occur in the DP group. Postoperative intubation time (72.6±40.1 h vs. 40.1±34.7 h ; p<0.05) was significantly longer in the Non-DP group. There were two in-hospital deaths due to stroke and respiratory failure in the Non-DP group, and one in-hospital death due to respiratory failure in the DP group. The postoperative maximum value of BUN (38.5±15.6 mg/dl vs. 30.8±9.8 mg/dl ; p<0.05) and s-Cr (1.9±1.0 mg/dl vs. 1.3±0.4 mg/dl ; p<0.01) were significantly higher in the Non-DP group. Conclusion : DP in OSG was an effective method for prevention of spinal cord ischemia, and for protection of respiratory and renal function.