Bone metastases occur in patients who have developed prostate cancer, and severely compromise the patient's quality of life. Here, we evaluated the quality of life in our inpatients diagnosed with prostate cancer with multiple bone metastases and bone pain. In our study, we evaluated pain using a pain diary, investigated the palliative effects of opioid dose, and assessed the quality of life using SF-36. The administration of chemotherapy and zoledronic acid (ZA) resulted in pain palliation, an anti tumor effect and improvements in the quality of life. We suggest that the administration of ZA might be an effective clinical strategy for multimodality advanced solid cancer therapy. We conclude that a 'combined' examination, in which a pain diary evaluating pain is considered in association with an SF-36 assessment evaluating quality of life is crucial to patient care. Palliat Care Res 2008 ; 3(2) : 308-315

Recently our intensive attention has been drawn to the effects of the air pollution on the respiratory organs. The authers have studied the vital capacity and timed vital capacity of the adults and children living in the Spa (hydrogen sulfide containing acid Spring Kusatsu) and the sulfur mine where the atomospheric air contains a small quantity of H₂S under 2ppm in spa and SO₂ under 1ppm in spa, and following results were obtained;
1. There was no significant difference in height and body weight among the children in the mine, the spa and the control district.
2. In the mine, many children complained of subjective symptoms concerning the respiratory organs.
3. Elevated vital capacity was found in the mine children.
4. There was no significant difference in the timed vital capacity between the control and the spa children.
5. In the control and the spa, the height showed the highest correlation to the vital capacity with men and the body weight to the vital capacity with women.
Concerning the partial correlation except the age factor, there was a higher correlation between the vital capacity and body weight than between the vital capacity and the height both with boys and girls.
6. Our results supported the Hewlett-Jackson's fomula in regression equation which can be used to predict the vital capacity.
7. There was no significant difference in the vital capacity of the residents between the two mines, which have different environmental and occupational conditions each other.
8. Concerning the timed vital capacity, there was no significant difference between these mines, but it was lower in the mine workers than in the office workers of the mine.
9. No significant difference in the timed vital capacity was proved between the smoker and non-smoker in the mine.

Older adults tend to lose the opportunities and abilities to pursue hobbies and perform various activities. Club activities provided in the community for old people seem to be beneficial in that the activities prevent them from becoming housebound, and improve overall QOL. In the present study, we conducted a survey by sending out self-answered questionnaire to 424 elder residents in rural areas. We collected information about their life circumstances, the presence or absence of physical pain, activities of Daily Living (ADLs), the degree of enjoyment from activities on the list, the frequency of going out, PGC morale scale and so on. The activities enjoyed frequently by the elderly were bathing, eating and watching TV. The degrees of enjoying eating and bathing showed positive correlations with the PGC morale scale, but the degree of enjoying gambling correlated negatively with the scale. A regression analysis was performed with the PGC morale scale as dependent variables. As a result, a significant model was structured to predict the life sati of the aged by making interpersonal distress, enjoyment derived from gambling, basic ADLs, physical pain and dwelling alone as indepeudent variables. These results will assist us in providing adequate health care to pelple of advanced age.
Morale ; pleasurable emotion ; Academic degree ; Bathing self care ; Activities

The aim of this study was to develop a new method for the determination of NO2 levels encountered in clinical settings as well as in environmental studies, using a bi−component atmospheric pressure ionization mass spectrometry(APIMS). Hydrogen (1%) diluted in pure argon was ionized by corona discharge in the first ionization component. Fifty ml of the analyte diluted in 250ml of composite air or carbon dioxide (CO2) was introduced into the second ionization component and analyzed. When composite air was used as the sample carrier gas, NO in the analyte was oxygenated and there was an increase in the NO2 content from that in the original analyte. However, when CO2 was used as the sample carrier gas, the level of NO2 in the analyte could be determined because CO2 did not change the NO2 content from that in the original analyte. A calibration curve with good linearity was obtained using the UG−410 APIMS system, with a regression equation of Y(%)=5.513*10-2 X(ppb) and a detection limit of 0.9ppb. Since APIMS detects NO2 directly within its system, the concentration of NO does not need to be measured. This system may be of great help in the accurate detection and determination of the concentration of low levels of NO2 during inhaled NO therapy
Carbon Dioxide ; ionization ; Spectrum Analysis, Mass ; Direct type of resin cement ; Adjudication