Quantitation of Metronidazole by reversed phase liquid chromatography using Supelco LC-ABZ column and a mobile phase containing an acid aqueous phase (pH Metronidazole ; Tablets

Study on some methods used to quantify berberine chloride showed that the UV measuring and volumetric titration methods did not express only amount of berberine chloride itself. It is necessary to apply high- performance liquid chromatography (HPLC) to achieve the optimal conditions for better splitting, higher accuracy…in order to apply more widely in testing products commonly in market with many components combined to berberine chloride. To find out optimal methods, which are suitable with condition of present some pharmaceutical units, it is necessary to experiment continuously methods such as UV measuring and volumetric titration,… using HPLC method to compare.
Berberine ; Tablets

Sustained release film coated tablets containing dexchlorpheniramine maleate were prepared in such a structure as two-third of drug were dispersed in Eudragit RS 100 to form insoluble matrix that gradually releases drug by diffusional mechanism, the rest was dispersed in the immediate release part. The core tablets were compressed by a wet granulation process and the film coated tablets by a routine film coating process with Eudragit E suspension. The formed coated tablets have suitable technical characteristics. The third formulation with Eudragit RS- drug ratio 2:1 has got the dissolution extent and the release rate in vitro similar to those of Polaramine 6mg repetabs. They also meet the requirements invitro release rate versus time for sustained release capsules containing Chlorpheniramine maleate by USP XXIII. Therefore, these film coated tablets with dexchlorpheniramine maleate may be candidates for a sustained release dosage form
dexchlorpheniramine ; Tablets

A microbiological extract of pollen, Cernilton was administered orally in dose of four tablets daily for 14 to 36 days in 25 cases of chronic prostatitis and following results were obtained. 1) Of the cases, 13 cases' (72%) Were improved and 7 cases(28%) were. not improved.. 2) No deleterious side effect were observed.
Pollen ; Prostatitis* ; Tablets

A microbiological extract of pollen, Cernilton was administered orally in dose of four tablets daily for 14 to 36 days in 25 cases of chronic prostatitis and following results were obtained. 1) Of the cases, 13 cases' (72%) Were improved and 7 cases(28%) were. not improved.. 2) No deleterious side effect were observed.
Pollen ; Prostatitis* ; Tablets

Chronic prostatitis has various symptoms and many problems in management. Recently a lipidosterolic extract of Serenoa Repens, Permixon has been reported to reveal potential antiandrogenic and anti inflammatory activities on prostate. Then we used Permixon on chronic prostatitis and following results were obtained. Permixon is administered orally in dose of 160mg., b.i.d. for 60 days in 31 cases of chronic prostatitis in 1st group, Permixon 160mg, with Cipro-floxacin 500mg, b.i.d. in 35 cases in 2nd group and Placebo 2 tablets, b.i.d. in 30 cases in 3rd group. In 1st group 36 cases(77.4%) were improved, 29 cases(82.8%) in 2nd group and 7 cases (23.3 %) of 3rd group were improved. Permixon is an effective drug in chronic prostatitis and there was no changes in laboratory findings and negligible side effects were noticed
Prostate ; Prostatitis* ; Serenoa* ; Tablets

Testing of pharmaceutical dosage forms for in vitro drug release and dissolution characteristics is very important for ensuring batch-to-batch quality control and to optimize formulations during product development. The ideal system for evaluating the drug release characteristics of poorly water-soluble drug formulations (as nifedipine tablets) is to maintain “sink conditions”. Flow-through dissolution systems (e.g. USP XXIV apparatus 4) can be used to over come solubility limitations. In this study, a flow-through dissolution system was installed to evaluate two sustained release nifedipine tablets (Adalat retard 20 mg and Nifedipine retard 20 mg- Life Pharma). The dissolution profiles prove that this system with the pump rate of 14-16 ml/min offers a method to evaluate nifedipine tablets, especially sustained release formulations.
Nifedipine ; tablets ; Pharmaceutical Preparations

Twenty-three bacteriologically positive leprosy patients were randomly selected from a leprosarium, randomly divided into four treatment groups, and given vaying dosages of Isoprodian, the tablet contained INAH 175mg, Prothionamide 175mg and DDS 50 mg, for five months. Group I: Initial 1/2 tablet dose per week with 1/2 tablet increment every weeks until 12 tablets were being consumed w.
Humans ; Leprosy* ; Prothionamide ; Tablets

Artemisinin and its derivatives are nowadays among the most effective antimalarials. However, the relapse rate with artemisinin and related compounds is relatively high. In order to overcome this, some experimental formulations of prolonged release tablet of artesunat are tested. The chosen formulation met the following demands: after an effective loading concentration of the active compound, there is a steady release of maintenance dose during 8 hours.
Artesunate ; Pharmaceutical Preparations ; tablets

On basis of colour reaction of artersunate with hydroxylamine hydrochloride in alkaline medium and then with ferric chloride solution in acidic medium, a method for assay of artersunate in tablets is proposed. The results of the determination are validated and they show that the method is precise, accurate, linear in studied range and relatively specific. While there is no more specific method, this method may be applied in determination of artersunate in tablets in place of current methods.
Artersunate ; spectrophotometry ; tablets