1.PHYSICAL ACTIVITY AND HEALTHY AGING IN ELDERLY PEOPLE
YUICHIRO KATO ; OSAMU KAWAKAMI ; TOSHIKI OHTA
Japanese Journal of Physical Fitness and Sports Medicine 2006;55(2):191-206
Regular physical activity has been regarded as a possible means to minimize the adverse physiological changes associated with aging, as well as to contribute to mental health and well-being in later life. To encourage increased participation in exercise among elderly people, and to emphasize the value of exercise in geriatric health care, this article provides an overview of the effects of primary care based physical activity on healthy aging. It is clear from the number of recently published papers on this topic that daily participation in 30 minutes or more of moderate physical activity should be recommended for elderly people. The results of physical activity interventions focusing on balance and resistance training in both home- and group-based exercises suggest that it is possible to improve physical functions and to prevent falls and disabilities in daily living. Multiple-element interventions (e. g., advice, as well as strategies to increase self-efficacy and motivation, and to eliminate barriers to participation), tailored to individual activity preferences, are likely to be more successful than more prescriptive single-focus interventions. A home-based physical therapy program can successfully enhance the independence of the frail elderly in community dwellings.
2.Effects of Swimming Exercise on Maximal Aerobic Capacity and Plasma Lipid-Lipoprotein Profile of Postmenopausal Women.
MITSURU HIGUCHI ; IZUMI TABATA ; YUTAKA YOSHITAKE ; MAMORU NISHIMUTA ; TOSHIKI OHTA
Japanese Journal of Physical Fitness and Sports Medicine 2001;50(2):175-184
This study was designed to evaluate effects of long-term swimming training on maximal aerobic capacity and sernm lipid and lipoprotein profile of postmenopausal women. In the first study, 12 swimming-trained postmenopausal women (age: 58±3 yrs, BMI : 22± 2 kg/m2, training distance : 3.6±1.6 km/wk, mean±SD) were compared cross-sectionally with 50 age-matched untrained women (58±5 yrs, 23±2 kg m2) . Swimming-trained women had higher maximal oxygen uptake (Vo2max) than untrained (34± 5 vs. 30± 5 ml/kg/min, P<0.05) . Serum total- and HDL-cholesterol (T-C and HDL-C) and triglyceride (TG) concentrations in swimmers were similar to those in untrained (T-C: 232±23 vs. 220±44 mg/dl, HDL-C : 69±15 vs. 72±17 mg/dl, TG : 83±21 vs. 99±67 mg/dl) . On the other hand, swimmers had higher serum LDL-cholesterol concentrations (LDL-C) than untrained women (161±28 vs. 138±25 mg/dl, P<0.05) . The second study was conducted to test the effects of a 2-year swimming program on Vo2max and serum lipid and lipoprotein concentrations of postmenopausal untrained women. After the swimming program 10 trained women (age : 59±7 yrs, BMI : 23±3 kg/m2, Vo2max : 30± 3 mlikg/min at baseline, training condition : one hour session, frequency: 1.5±0.4 times/week during the program) and 12 untrained women (60± 5 yrs, 23± 3 kg/m2, 29± 5 ml/kg/min at baseline) were retested. No change in BMI was observed in the two groups. At the 2-year follow-up, the trained women increased Vo2max (34± 5 ml/kg/min, P<0.05), whereas no change in Vo2max was observed in the untrained women (30± 5 ml/kg/min) . No changes occurred in concentrations of T-C (Trained : 238±25 233±21 mg/dl, Untrained : 236±20 236±32mg/dl), HDL-C (Trained : 70 ± 15→74 ± 16 mg/dl, Untrained: 69 ± 15→69 ± 14 mg/dl), LDL-C (Trained : 150 ±29 144±27mg/dl, Untrained : 144±15→145±23mg/dl), and TG (Trained : 90±32 74±25 mg/dl, Untrained : 115±81 106±52mg/dl) . These results suggest that although a long-term swimming program can increase maximal aerobic capacity, favorable changes in sernm lipids or lipoproteins can not be expected for postmenopausal women.
3.Study of the Inhibitory Effect of Coix lachryma-jobi L. var. ma-yuen Stapf on Carcinogenesis and Inflammation
Rihou SUZUKI ; Harukuni TOKUDA ; Nobutaka SUZUKIi ; Kazuo UEBABA ; FengHao XU ; Toshiki KAWABATA ; Tomihisa OHTA ; Shigeki OHTAKE
Japanese Journal of Complementary and Alternative Medicine 2013;10(2):75-85
Adlay( Coix lachryma-jobi L. var. ma-yuen Stapf ) is a grass crop that has long been used in traditional medicine as a nourishing food. This study investigated the inhibitory effects of adlay related substances on carcinogenesis and anti-inflammation. The hot water extract of all parts of adlay (CRD) were compared with the hot water extract of dehulled adlay (yokuinin). In addition, the Monoolein and Trilinolein components of adlay were compared.
As a screening date, antiproliferative effect of human cancer cells showed weak biological potency on physical dose response. Prevention effect of carcinogenesis and anti-inflammatory effect were also observed in all samplles. CRD showed stronger anti-UVB inflammatory effect than that of yokuinin; while yokuinin showed stronger anti-heating injury inflammatory effect than that of CRD. Moreover, Monoolein showed stronger effect than Trilinolein on both prevention effect of carcinogenesis and anti-inflammatory effect. These result indicated that these two extracts of adlay exhibited inhibitory effect on both tumor and inflammation. In addition, it is also suggested that Monoolein is more effective than Trilinolein.
4.Acute Oral Toxicity Test of Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats
Hirotaka HAYASHI ; Yasuyuki OHTA ; Takanari ARAI ; Yasuko SHIMANO ; Fumihide TAKANO ; Jeffry Michael STRONG ; Toshiki ENOMOTO ; Kazuo UEBABA ; Tomihisa OHTA ; Nobutaka SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2009;6(2):105-110
Coix lacryma-jobi L. var.ma-yuen Stapf (Coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of Coix seed has rarely been evaluated. We performed a safety test of hot water extract of all parts of Coix seed (CRD extract) in rats. CRD extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.
5.28-day Repeated Dose Oral Toxicity Test of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats
Hirotaka HAYASHI ; Takanari ARAI ; Jeffry M. STRONG ; Harukuni TOKUDA ; Yasuko SHIMANO ; Yasuyuki OHTA ; Toshiki ENOMOTO ; Kazuo UEBABA ; Tomihisa OHTA ; Nobutaka SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2009;6(3):131-135
Coix lacryma-jobi L. var.ma-yuen Stapf (coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of coix seed has rarely been evaluated. We performed a 28-day repeated dose oral toxicity test of hot water extract of all parts of Coix seed in rats. The extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.