1.EFFECTS OF “LIVING HIGH AND TRAINING LOW” ON PULMONARY CIRCULATION HEMODYNAMICS AND ENDOTHELIAL NITRIC OXIDE SYNTHASE PROTEIN EXPRESSION IN PULMONARY ARTERY OF RATS
TOMOYA KASHIWAGI ; TOMONOBU SAKURAI ; KAZUHIRO MINAMI ; KENTA SUZUKI ; OSAMU KASHIMURA
Japanese Journal of Physical Fitness and Sports Medicine 2009;58(2):285-294
The present study was to evaluate endothelial nitric oxide synthase (eNOS) protein expression and hemodynamics of pulmonary circulation in rats of "Living high and Training low" (LH+TL). The Sprague Dawley strain of male rats were used at the age of 9 weeks. They were divided according to four conditions of a living low (LL) group, living low and training low (LL+TL) group, living high (LH) group and LH+TL group, for 10 days. We assessed the effects of LH+TL on exercise-induced pulmonary arterial pressure and blood lactic acids under sea-level altitude in catheter-implanted conscious rats. Also, we measured the pulmonary artery under anesthesia and analyzed eNOS protein expression by western blot analysis. The blood lactate levels in the LH+TL rats decreased after maximal treadmill running compared to LL, LL+TL and LH rats (p<0.05). The increase in pulmonary arterial blood pressure with exercise was significantly lower in the LH+TL group than in the LL group (p<0.05). The eNOS protein expressions of pulmonary artery were higher in the LH+TL group than in the LL group (p<0.05). This study indicates that LH+TL reduced the increase of pulmonary arterial blood pressure with exercise at below sea-level altitude. In addition, eNOS protein expressions were enhanced in the pulmonary arteries of LH+TL rats. Thus, we conclude that the high altitude training of LH+TL was a useful method for improvement of endurance exercise ability and this improvement may be associated with pulmonary arterial response.
2.A Case of Primary Chylopericardium in Which Three-Dimensional Computed Tomography Scan with Lymphangiography Was Useful
Noriyuki Kato ; Hajime Sakurai ; Tomonobu Abe ; Hiroki Hasegawa ; Sadanari Sawaki ; Takahisa Sakurai ; Junya Sugiura
Japanese Journal of Cardiovascular Surgery 2006;35(4):246-250
A 36-year-old previously healthy woman with cardiomegaly on a routine chest X-ray was given a diagnosis of primary chylopericardium after pericardial puncture revealed milky effusion. Endoscopy-assisted ligation of the thoracic duct and creation of a pericardial window was performed. The operation was greatly facilitated by the preoperative three-dimensional CT scan with lymphangiography that precisely demonstrated the distribution of the thoracic duct and other lymphatic ducts.
3.A Report of Consideration for Physician's Recognition Award (PRA) in American Medical Association.
Nobuya HASHIMOTO ; Haruhiko SAITO ; Makoto AOKI ; Masahiko HATAO ; Tomonobu KAWANO ; Hideya SAKURAI ; Tadashi MATSUMURA ; Osamu NISHIZAKI ; Toshiro OHMURA ; Shoichi SUZUKI
Medical Education 2000;31(3):153-157
The committee of continuing medical education in Japan Society for Medical Education discussed on PRA of American Medical Association [AMA]. We have first analyzed the brochure of PRA for the members of AMA, and then prepared the questionnaire for AMA. We were able to obtained the answers to the questionnaire which were sent to AMA through courtesy of Japanese Medical Association (JMA). It was realized that AMA emphasizes an importance of PRA for medical practice to the patients; nevertheless acquisition rate of PRA is actually low, and so AMA proceeds with efforts towards completion of PRA.