Injury of the nail bed is commonly encountered in the emergency department. Despite the importance of initial management, difficulties such as long duration of operation and need of skill hinder the practice. Tissue repair with tissue adhesives, like 2-N-butylcyanoacrylate (Histoacryl(TM)), is a common replacement for suture repair. Here we describe a case of nail bed injury, which was repaired with Histoacryl(TM), and the method of repair.
Emergencies ; Nails ; Sutures ; Tissue Adhesives

No abstract available.
Fibrin Tissue Adhesive* ; Fistula* ; Tissue Adhesives*

Objective: To compare the tensile strength of fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage to conventional nylon 10-0 sutures in sealing central linear corneal lacerations. Methods: An experimental in-vitro study was performed on 74 porcine eyes. A 27-gauge needle connected to an infusion system with balanced salt solution was inserted into the anterior chamber and the bottle height was adjusted accordingly. Full-thickness central corneal lacerations were created using a 3.2 mm keratome knife for the initial incision and enlarged by a 5.2 mm knife. The wounds were sealed with fibrin glue (Tisseel®), 2-octyl cyanoacrylate (Dermabond®), liquid ocular bandage (OcuSeal™), and nylon 10-0 with 3 sutures. Tensile strength of the wounds was measured by recording the bottle height above the level of the porcine eyes before leakage was detected and this was converted to IOP values. One-way ANOVA and post hoc t-test were used to analyze the data. Results: Mean maximum IOP where leakage was resisted for the nylon 10-0 suture group was 52.37 ± 7.16 mm Hg. The mean maximum resisted IOP for the fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage was 46.34 ± 12.64 mm Hg, 55.13 ± 10.46 mm Hg, and 56.99 ± 8.27 mm Hg respectively. There was no significant difference between the sutures and all of the adhesives groups (p=0.08, p=0.34, and p=0.08) and between 2-octyl cyanoacrylate and liquid ocular bandage (p=0.57). 2-Octyl cyanoacrylate and liquid ocular bandage demonstrated higher mean IOP as compared to the fibrin group (p = 0.024 and p = 0.007). Conclusion Fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage were shown to be effective in sealing 5.2 mm linear corneal lacerations, with 2-octyl cyanoacrylate and liquid ocular bandage being superior to the fibrin glue.
Tissue Adhesives ; Tensile Strength ; Fibrin Tissue Adhesive

PURPOSE: To study tissue adhesive effectiveness in with laceration at various body sites. METHODS: From January 2007 to December 2009, we collected the data of laceration patients treated using tissue adhesive in the emergency department of a university hospital. Data concerning treatment satisfaction were collected twice and analyzed. RESULTS: Of the 8665 patients with laceration, 196 (mean age 23 years, 106 males) were treated using tissue adhesive. Many of the 196 patients were <15-years-of-age. Involved body sites mainly comprised head/neck, followed by the upper extremities. The procedure was the most rapid of all treatments. CONCLUSION: Emergency physicians can reliably use tissue adhesive treatment for various lacerations in the emergency setting.
Emergencies ; Humans ; Lacerations ; Tissue Adhesives ; Upper Extremity

Broncho-esophageal fistula is a disease of varying etiologies. Spontaneous fistula occurs as a result of malignancy, radiotherapy or inflammatory disease. The majority of fistulas are caused by iatrogenic causes. Treatment of fistula usually consists of surgery and conservative management. Recently, it has been reported that broncho-esophageal fistula can be treated endoscopically using tissue adhesive agent such as Histoacryl(R) and fibrin glue. We report a case of broncho-esophageal fistula as a complication of tuberculosis that was successfully treated by radiological Histoacryl(R) injection therapy with a review of literatures.
Fibrin Tissue Adhesive ; Fistula* ; Radiotherapy ; Tissue Adhesives ; Tuberculosis

2-Octylcyanoacrylate(Dermabond(R)) has an eight-carbon alkyl derivatives that is less inflammative with stronger adhesive property than its short chain derivatives (ie. 2-ethylcyanoacrylate, 2-butylcyanoacrylate).1 To assess the effectiveness of the tissue adhesiveness of 2-octylcyanoacrylate with dermal suture for the closure of head and neck incision wound, 20 patients who underwent thyroidectomy at Asan Medical Center were studied. Ten patients underwent skin closure with paper adhesive and the other 10 with the new tissue adhesive, 2-octylcyanoacrylate. At the time of 2 weeks and 3 months respectively, the incisions were evaluated by authors. Photographs of the incisions were rated using a visual analogue scale by 2 plastic surgeons who had no idea of the method of skin closure. The length of time required for skin repair was increased(161 seconds 2-octylcyanoacrylate vs 65 seconds paper adhesive), and the incision closed with tissue adhesive had similar cosmetic scores(84mm 2-ocylcyanacrylate vs 82.5mm paper adhesive). But the satisfaction of patient was higher in 2-octylcyanoacrylate group. The practical advantages of tissue adhesives are easy application, convenience of taking early showers and no need of suture removal. In conclusion, 2-octylcyanoacrylate is found to be an effective method of skin closure in clean head and neck incisions.
Adhesiveness ; Adhesives ; Chungcheongnam-do ; Head ; Humans ; Neck ; Skin ; Sutures ; Thyroidectomy* ; Tissue Adhesives ; Wounds and Injuries*

Adhesives ; therapeutic use ; Animals ; Humans ; Neurosurgical Procedures ; methods ; Rabbits ; Tissue Adhesives ; therapeutic use

Inadvertent perforation of the globe, granuloma and hypersensitivity reaction have been recognized complications of the strabismus surgery. We performed experimental strabismus surgery with No.240 retinal band and histoacryl(group I), histocracyl only(group II), 6-0 vicryl(group III) in rabbit model to determine whether these techniques can replace the classic suture and decrease its complications. We measured maximum adhesion power by force gauge and observed histopathologic findings after sacrificing four rabbits at 1 day, 1 week, 4 week, and 8 weeks, respectively following experimental strabismus surgery. There were chronologically increasing tendency of adhesion power in all groups but no statistically significant differences among three groups. Pathologically inflammatory and foreign body reactions were decreased with time and there were no differences of inflammatory reactions among three groups. At four weeks after the experiment, there was encapsualation lined with loose fibrous tissue around the band in group I.In conclusion, We found that experimental strabismus surgery with tissue adhesives and No.240 retinal band showed good adhesion power and minimal tissue reaction. So, it is possible to do posterior fixation suture with tissue adhesive and No.240 retinal band in classic strabismus surgery.
Foreign Bodies ; Granuloma ; Hypersensitivity ; Rabbits ; Retinaldehyde ; Strabismus ; Sutures* ; Tissue Adhesives*

The ideal method of wound closure should be simple, rapid, inexpensive, painless, and bactericidal, and should achieve optimal cosmetic results. Tissue adhesives offer many of these characteristics. Until recently, the only commercially available tissue adhesive was 2-butylcyanoacrylate. A new tissue adhesive, 2-octylcyanoacrylate (Dermabond(R)), offers several advantages over 2-butylcyanoacrylate. It is more pliable and less brittle. To compare a new tissue adhesive, 2-octylcyanoacrylate, with standard wound closure techniques for the repair of open wound, two groups of each 20 rats were studied. Two groups were similar for demographic and clinical characteristics. Photographs taken at three months were rated by seven plastic surgeons blinded to the method of closure. There was no difference between two groups for appearance or complication. In conclusion, wound treated with Dermabond(R) and standard wound closure techniques have similar cosmetic results 3 months later, and Dermabond(R) is a faster method of wound repair that has cosmetic results similar to the use of sutures.
Animals ; Rats* ; Sutures ; Tissue Adhesives ; Wound Closure Techniques* ; Wounds and Injuries*

In order to compare the amount of surgically induced astigmatism among sutureless group(Group 1),10-0 nylone suture group(Group 2),and using tissue adhesive group(Group 3),we analysed a series of rabbit cataract surgery cases in these three groups. We performed cataract surgery on 30 eyes of 15 rabbits by Irrigation and aspiration technique. After cataract surgery,10 eyes by sutureless technique,10 eyes were closed by conventional 10-0 nylon suture technique, and 10 eyes by tissue adhesive(Beriplast) technique.We collected keratometric data before and after surgery(At 1,2,4,8 weeks).In postoperative astigmatic change,three groups had the distinct features in the evolution for postoperative astigmatism.The group 1 showed early against-the-rule(ATR)astigmatism,which advanced ATR and showed about 0.5D astigmatic change at 8 weeks.The group 2 showed early with-the-rule(WTR)astigmatism about 1.13D,which advanced toward ATR from 1week.The group 3 showed little ATR about 0.2D,which was minimal change in astigmatism.At 8 weeks after operation,there was no signifi-cant difference in the astigmatic change among the three groups(P>0.05), which were no complications observed. In this study,the tissue adhesive(Beriplast)seem to be a simple,effective and less induced astigmatic changing corneoscleral suture technique than other suture techniques
Astigmatism* ; Cataract* ; Nylons ; Rabbits ; Suture Techniques ; Sutures ; Tissue Adhesives*