Type 2 diabetic patients are usually accompanied by dyslipidemia.The cardiovascular residual risk is still high in these patients,even with glycemia,blood pressure,and plasma lipids well controlled.In this review,the relationship of plasma lipids and changes in lipoprotein particles with cardiovascular risk is discussed.

PTEN gene is considered to be the first discovered tumor suppressor gene with dual specificity phosphatase activity.The research has shown that the increasing popularity of PTEN rests on its important roles in cancer cell growth,differentiation,signaling transduction and cell apoptosis.Besides,the mutation of PTEN is related to cancer initiation and progression.The recent advances on PTEN gene in malignant tumors will be reviewed in this paper.

Objective To explore relationship between magnetic resonance imaging (MRI) performance and lipid levels in pa-tients with lacunar infarction (LI) .Methods 68 patients with LI were retrospectively analyzed ,62 cases patients without heart ce-rebrovascular disease in the same period were choosen as control group ,the multivariate logistic regression was used to analyze the relationship between MRI performance ,the changed level of lipid .Results A total of 299 lacunar lesions were detected by MRI ,in which there were 58(19 .40% )in the left cerebral hemisphere ,26(8 .70% ) in the right hemisphere ,73(24 .41% ) in the bilateral basal ganglia ,27 (9 .03% ) in thalamus ,54 (18 .06% ) in the lateral ventricles corona radiata ,39 (13 .04% ) in brainstem ,and 22 (7 .36% ) in cerebellum .TC ,TG ,LDL-C and Ox-LDL levels in LI patients were significantly higher than the controls (P<0 .05) , while HDL-C levels were significantly lower than the controls (P<0 .05) .Multivariate Logistic regression analysis showed that relative risk of TC ,TG ,LDL-C ,HDL-C and Ox-LDL to LI were 1 .56 ,1 .27 ,1 .39 ,1 .46 and 1 .44 .Conclusion The MRI manifestations and lipid levels of LI have a certain degree of correlation ,and elevated blood lipid levels may be important risk factors for LI .

Objective:To study the variation of X chromosome centromeric Alpha Satellite DNA in Klinefelter's syndrome patients,their parents and normal individuals and to discuss the mechanism of Klinefelter's syndrome X chromosome nondisjunction.Methods:The multi-copies of a 2Kb tandem repeat unit on X chromosome of centromeric Alpha Satellite DNA were simultaneously amplified with reasonable primers by (representative sampling of multiple repetitive units,rep)PCR,and the mechanism of X chromosome aneuploidy resulted by abnormal structure of centromere was investigated.Results:1774bp,570bp and 1410bp,583bp,220 bp (three short fragments are resulted by deletion in alpha satellite DNA) were detected in Klinefelter's syndrome patients,their parents and normal karyotype controls.There were 1774bp and 1410bp DNA fragments in all of samples.The relative frequencies of 570bp and 583 bp were significantly higher in Klinefelter's syndrome patients than in normal karyotype controls,the 220bp was not found significantly different in the three groups.Conclusion:Deletion in the region of Alpha Satellite DNA is present at centromeres of all human X chromosome,while Klinefelter's syndrome patients and their parents show higher frequency than normal individuals.These results imply that analysis of deletion on X-specific ?satellite of the parents during the pre-pregnancy and pregnancy plays a important role either in estimating the risk of repruducing Klinefelter's syndrome or in providing the guideline for prenatal chromosome diagnosis of villus and amniotic fluid.

The roots ofApium graveolens L. have been widely used in Uighur Medicine. Research has shown that roots ofApium graveolens L. has good clinical efficacy in the aspects of liver protection and lipid decreasing, hyperlipidemia treatment and so on. This article reviewed research on the chemical components, extraction process, and pharmacological action of roots ofApium graveolens L. so far, with purposes to better develop and utilize roots of Apium graveolens L., and provide references for follow-up study.

Objective To investigate the influnce of dexamethasone pretreatment on the expression of ICAM 1 and neutrophil infiltration in brain tissue of hypoxic ischemic neonatal rats Methods Forty eight neonatal rats were made to model with hypoxic ischemic encephalopathy(HIE) The control group and the dexamethasone group were respectively injected intraperitoneally with normal saline 10 ml/kg, dexamethasone 0 1 mg/kg before hypoxia ischemia;all animals were killed 24 hours after hypoxia ischemia Immunocytochemistry was used to determine the absorbency of ICAM 1 The damage grade of neurocytes and leukocyte infiltration were recorded for the histopathological study Results Compared to the control group,the mean absorbency(A) of ICAM 1, the damage grade of neurocytes and neutrophil infiltration of the dexamethasone group were all obviously decreased( P

Objective To discuss the methods and effects of replantation to treat complex thumb severance. Methods 56 cases of complex thumb severance combined with soft tissue defects were treated with simple vessel transplantation, veno flap transplantation, dorsal index digital island flap transplantation, digital artery transfer, transfer of radial index digital artery pedicled island flap, or veno arteriolization. The soft defects were repaired by the transfer of extensor index finger tendon and superficial ring finger flexor tendon. Results 50 cases survived and 6 cases failed, with the survival rate being 89%. 42 cases were followed up for 5 to 25 months. The function of the treated thumbs was assessed as excellent in 10, good in 25 and bad in 7. The excellent and good rate was 83%. Conclusion Complex thumb severance can be treated by unconventional replantation so as to achieve good effects.

Objective To investigate the effect of different administrations of insulin-like growth factor 1(IGF-1) on cerebral hypoxia-ischemia injury in neonatal rats.Methods Forty neonatal rats were divided into four groups: control group, nasal-treated group, intravenous-treated group and sham-operated group. The two treat groups were given IGF-12.5?g (dissolved in 0.1 ml NS) intravenously or by nasal immediately after hypoxia, respectively. Normal saline (0.1 ml) was used intravenously in control group and only disassociation of common carotid artery was performed in sham-operated group. The animals were killed 24 hours after hypoxia. The expression of caspase-3 protein was determined by immunohistochemistry method, also pathological change was studied under light microscope.Results Compared to the control group, the expressions of caspase-3 protein in treat groups were obviously decreased (all (P

In order to improve the scientificity and rationality of materiel management,we developed the materiel management system and realized the computerizing of material management. This system can solve all problems in material computerizing which occur during the process from the material application to its abandonment. Aiming at solving disadvantages in human management,the utilization of this system will greatly reduce the staff's work load,enhance the working efficiency and make the material management standardized.

Through the network medical teaching and guidance system,the live video of clinical medicine activity can be multicast by MPEG2 code and MPEG4 code simultaneously on the LAN or WAN.It may meet the request of different network bandwidth,realize the bidirectional audio or video frequency at the same time,and satisfy the clinical teaching or guidance need.The client port can be deployed in the random terminal on LAN or WAN,while the user with the authorization can see the high clear surgery image in real time at any place,make communication through the bidirectional audio and video system,and even remotely control the camera's lens angle and focus for perfect video effect.