Aims: Herbal and medicinal plants bioactive compounds of Jatropha curcas, Piper nigrum and P. betle have been shown to possess therapeutic properties. This study investigates the presence and characterization of phytochemical compounds as well as to evaluate the antimicrobial activities of the methanolic crude extract of the leaves and seeds of J. curcas, P. nigrum L. and P. betle. Methodology and results: The study on antibacterial and antifungal efficacy of the crude extracts of leaves and seeds were carried out using standard disc diffusion method. The crude extracts were found to exhibit an average response of antimicrobial activity with the inhibition zones ranged from 3% to 28% for antibacterial and from 21% to 79% for antifungal activity. Among all extracts, the leaf extract of P. betle showed a good antibacterial activity against Staphylococcus aureus and excellent antifungal properties against Aspergillus niger and A. flavus. The phytochemical screening analysis revealed the presence of saponin, tannins, glycosides, terpenoids, reducing sugar, flavonoid and anthraquinones. However, phlobatannins was not present. Total phenolic content (TPC) and total flavonoid content (TFC) were highly detected in the crude extract of P. betle and recorded as 13.33 mg of gallic acid equivalents, GAE (mg/ 100 mg sample) and 0.88 mg of RE (mg/100 mg sample), respectively. GC-MS analysis of the bioactive compounds reveals the presence of diethyl phthalate, 2-hexadecen-1-ol (Phytol), hexadecanoic acid, piperine, phenol and other minor compounds. Conclusion, significance and impact of study: The study suggested that P. betle has a potential as a source for antimicrobial agent from plants extracts. Nevertheless, further studies are needed to elucidate their precise mechanism of action.
Therapeutics

The randomized Controlled Trial is the standard design to prove the effectiveness of drugs or other forms of interventions. In this type of clinical research, individuals are randomly assigned (randomization) to either of the two or more groups, one with the intervention the other without the intervention being tested or another intervention. When done properly, it can provide the best evidence of effectiveness
Therapeutics

The objectives of national program of antituberculosis during 2001-2010 were to reduce to 50% of incidence and 50% of prevalence in order to reduced the morbidity rate, mortality rate of tuberculosis; early detect 75% of patients with the pulmonary tuberculosis with M. tuberculosis in the sputum; and reduce maximally the risks of drug resistance by successful treating 85% of patients under deployment of strategy of DOTS for 100% of tuberculosis patients
Tuberculosis ; therapeutics

We study 101 subjects including 44 men and 60 women who were defined that they got Atherosclerosis by vascular ultrasound. Upper 80% in the population are the middle aged and elderly subjects. The average of age: 61+/-9.32.The important measurable risk factor of atherosclerosis is disorders of lipid metabolism, the second is hypertension, the third is diabetes. The significant clinical event of atherosclerosis vascular disease is myocardial ischemia. The ratio of different cardiovascular and neurological events is relatively low, approximately 4-8%. We use simvastatin, fibrate, acid folic and omega 3 as therapeutic intervention on atherosclotic lesions.
Artherosclerosis ; therapeutics

Idiopathic scoliosis with Cobb angle between 20o and 40o is more common in female than in male, especially in adolescent girls (10 to 16 years). 18 patients with idiopathic scoliosis were treated at B¹ch Mai Hospital using TLSO brace jacket. The result showed that this brace jacket is convenient and does not impede the activities. It can correct about 30% in initiation. The level of correction decreases over time of bracing and after removing brace. After 2 years, there were 9 cases have improved by 50% in curve. The brace can prevent progress of scoliosis with Cobb angle of 40o.
Scoliosis ; Therapeutics

A study on female patients with ages of 15-30, and immunothrombocytopenic haemorrhage has shown that the severe anemia occurred mainly due to metrorrhagia (80%). For patients treated actively by corticoids that platelet has been a good response, it should not use corticoids within continuous 6 months while they should have a treatment course before menstruation for a week and followed by 4 days. All 7 patients treated actively responded with corticoids.
Hemorrhage ; Therapeutics

Maduxin ointment is totally extracts from the leaves of the Maduca pasquieri and has been applied in burn treatment in Vietnam since 1987. We studied the effects of Maduxin on the collagenization at burn wounds by following up the changes of OH-Pro content at slaked lime burn wounds - a popular type of burn in Vietnam in comparison with the effects of SSD in burn treatment. Our study was carried out in 21 slaked lime burn patients who were treated at the Vietnam Burn Institute from May to September 1997. The results indicated that OH-Pro concentration increases related to collagen synthesis during the burn wound healing. In the slaked lime burn wounds treated by Maduxin OH-Pro level in burn tissue increases more than in the wounds treated by Silvesufadiazin during the healing.
Hydroxyproline ; Therapeutics

Plication of horizontal recti with many advantages in the treatment of strabismus has been applied by many authors in the world, but not yet in Vietnam. Objectives: to evaluate the results of this surgery that applied in Vietnamese. Methods: Prescriptive, longitudinal prospective study that had been done in Hanoi National Institute of Ophthalmology from 9/2003 to 9/2004. Results: In postoperative period, 83.3% of cases with exotropia and 89.6% of cases with esotropia are well corrected after 6 months, 100% of operated eyes are well healed with a smooth conjunctive scars and 52.62 % of operated patients have got a full binocular vision after 3 months following up. The rate of the eyes with suspected amblyopia is reduced from 18.8% to 9.8%, with moderate amblyopia is also reduced from 8.8% to 2.4% by 6 months postoperatively, but the rate of the eyes with severe amblyopia is not significantly changed after surgery. Conclusion: Plication of horizontal recti is a safe, effective method for correction of strabismus, especially when it is necessary to do surgery on many extra-ocular muscles in the same eye.
Strabismus ; Therapeutics

Retrospective study from January 1999 to October 2003 on 90 patients of acute necrotizing pancreatitis (ANP) treated at Viet Due Hospital in which demonstrated: male patients represented 56.7%; alcoholism 18.9%. The interval between onset syndrome and operation was: less than 48 hours: 14.4%; from 2 to 14 days: 74.4%; more than 14 days: 11.2%. Surgical procedures were performed: resection for the necrotic tissue and ample drainage (86 cases), pancreatectomy of head part and main part was done on 2 cases, abscess drainage for 2 cases; jejunostomy: 67 cases; biliary: 53 cases; management of other lesions for 3 cases; postoperative complication was presenting 35.6%; the mortality was 18.9%. This study showed that necrotizing pancreatitis did not well respond to medical treatment. The best time to take operation is on the third day still onset the syndrome. The surgical procedures as resection for necrotic tissue and drainage is most often management. Ample pacreatectomy is not employed due to it cause high mortality, can be up to 100%. Regarding patient nutrition, the jejunostomy is more effective and it can control infection as well. The biliary drainage can be indicated if bile duct was obstructed.
Pancreatitis , Therapeutics

A study on the current status of malaria and the efficacy of interventions among migrants was carried out in one district with high malaria transmission in Central Highland - Vietnam from 2002-2004. The findings of the study showed that: The malaria prevalence of clinical and parasite were high in the migrant, especially among new comers (clinical rate: 5.2% and parasite rate:4.3%). These rates were higher than that in local people (clinical rate:5.0% and parasite rate: 3.1%) and were still high in the year 3 and decreasing after 3 years. The applied interventions for migrant were: strengthening of the health education, improvement of community health workers and they were effective. The prevalence and incidence of malaria were reduced from 3.9 to 0.65% and 45.3 to 28.1/1000 population, respectively, after 3 years. The malaria rate was reduced by 40-60% compared with that in the control group.
Malaria ; Therapeutics