A comparison of simple true-false questions (STFQ) and multiple choice questions (MCQ) plus multiple true-false questions (MTFQ), in the same contents was done at the graduation examination of our department (on 1987. 12. 7.). The mean score of STFQ was 83.7 mark and its standerd deviation was 4.6 mark, and in MCQ plus MTFQ the value was 77.1, 9.0, respectively. At the same student, the mark of STFQ and MCQ plus MTFQ was correlated. We concluded that the handling of the question with high percent of correct answer was induction of the individual total item check method. Then, evaluation got more validity.

Objectives: To analyze the effect of human placental extracts (HPEx) on hepatocellular carcinoma cells in vitro. Methods: The hepatocellular carcinoma cell lines, namely, HLE and Huh-7, were used. The cells were subjected to a growth assay using the formazan dye method; the effect of combination treatment with sorafenib and HPEx was also assessed. The preventing normal cell damage effect of HPEx was analyzed by virtual therapy where possible; the experimental protocol was constructed on the basis of pre- and post-sorafenib treatment data. Cytotoxicity was measured by lactate dehydrogenase (LDH) assay. Results: HPEx caused significant dose-dependent suppression in the growth of HLE and Huh-7 cells. These tumor cells were significantly suppressed by combination treatment with HPEx and sorafenib. In addition, HPEx potentiated sorafenib sensitivity against tumor cells, and significantly prevented sorafenib-induced cytotoxicity in primary cultured rat hepatocytes under all designed experimental conditions. Specifically, pre-treatment with HPEx had a greater effect than post-treatment with HPEx. Conclusion: HPEx suppresses tumor cell growth, potentiates sorafenib efficacy, and has a preventing normal cell damage effect; this triple functionality of HPEx makes it a useful agent for liver cancer therapy.

Generally, sport players of boxing or football who contact roughly with other players use mouth guard during match or game to prevent the breaking of jow boneor bursting of soft oral cavity. Moreover, mouth-guard are used for the purpose to lighter the load to root of teeth and to improve the skill and power of sport's player.
The purpose of this study was to examine the charactaristic of unfitted by H shape-mouth guard compared to U shape mouth guard.
The following results were obtained.
1. The H shape-mouth guard of this study could reduce the impact to 1/7 level.
2. A relative decrease in ventilation level was shown when H shape mouth guard fitted.
3. With reference to respiratory function, reduction of the amount of oxygen up-take was not observed at heart rate lower than 170 beats/min, and in this case a player feells subjective symptom of stiffing.

We have developed a mouth guard which has revolutionized the shape and material of the conventional mouth piece. The H shape mouth guard has the unique shape like that of an H. Even with the new shape of the mouth piece it does not hinder the performance of the wearer. The following are the fundamental data collected by our group. In this study we examined its influences on leg power, the carry (the distance a golf ball is hit) and the motion of the club head during a tee off.
The results are as follows:
1) By wearing or setting the mouth guard, the variation of leg power, measured with a Sybex II, showed an increase at selected angular verocity. The rate of increase averaged aproximately 15%.
2) The amount of work in anaerodush, an intensive, but short exercise, increased significantly by 1.25 seconds.
3) As for golf, all four of the test subjects joint performance increased their carries by 5.2 to 11.6 yards, using a 1st wood.
4) Also the fluctuation of the head of the club decreased from 7.3 cm to 3.6 cm on average.
Our group have found that the new H shaped mouth guard can absorb shock as well as not hinder the performance of the individual who is wearing it. Thus, the H shape mouth guard can be worn during sports to enhance the participant's performance.

The purpose of this study was to examine the effect of physical inactivity, produced by prolonged bed rest, on the excitability of the spinal motor neuron pool in humans, using the activity of soleus H-reflex.
Eight healthy male subjects underwent continuous bed rest with 6 degree head-down tilt for 20 days (BR group) . Ten different healthy male subjects maintained their usual daily life during the observation period for 20 days (control group) . Recruitment curves of H-reflex and M-wave were obtained from every subject. H slope/M slope (H slp/M sip) which shows the excitability of spinal motor neurons was calculated by using data in the recruitment curve.
The H sip/M sip in the BR group significantly increased after BR, compared to the pre-BR values (p<0.05) . In the control group, however, there were no significant differences in the H slp/M sip between the pre and the post-observation values. At the baseline, the H slp/M sip showed no significant differences between the BR group and the control group. After the BR, the H slp/M sip in the BR group significantly increased compared to the control group after the observation period (p<0.05) .
This study suggests that the excitability of the monosynaptic spinal motor neuron pool is facilitated by physical inactivity during BR.

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
5-Methoxytryptamine/pharmacology ; Acetylcholine/pharmacology ; Animal ; Calcium/metabolism ; Guinea Pigs ; Pancreatic Ducts/metabolism* ; Pancreatic Ducts/drug effects ; Secretin/pharmacology ; Serotonin/pharmacology ; Serotonin/metabolism* ; Serotonin/analogs & derivatives* ; Vasodilator Agents/pharmacology

No abstract available.
Animal ; Bicarbonates/metabolism* ; Biological Transport/physiology ; Pancreatic Ducts/metabolism* ; Perfusion

In the Guideline for treatment of chronic headache published by Japanese Headache Society, Ibuprofen and Acetaminophen are proposed for the acute treatment of migraine in children. But prophylactic treatment of pediatric migraine is not established. We report the efficacy of Kampo medicine for preventing migraine in children and childhood periodic syndromes. We use a variety of Kampo medicine for 9 pediatric migraine and periodic syndromes patients from 8 to 15 years old. All 9 patients improve their headache and associated symptoms including abdominal pain, vertigo, nausea and vomiting. After treatment the mean average of Headache Impact Test-6 (HIT-6) improve from 63.66 points to 45.77 points. Kampo medicines is effective for migraine in children and childhood periodic syndromes.