The short time antibacterial effect of tetracaine hydrochloride was studied. S. aureus, Coagulase Negative Staphylococcus and P. aeruginosa were each incubated with tetracaine hydrochloride(preservative free) for 18 hours or for 2 minutes and then diluted and cultured on nutrient agar plate. Colony counts were done after 18 hours. In cases of 18 hours incubation, there was no growth of microbials in 0.5%, 0.1% tetracaine hydrochloride, but there was no inhibitory effect of 0.02% of tetracaine hydrochloride on growth of microbials, irrespective of inoculum amount. In cases of 2 minutes incubation with 0.5% tetracaine hydrochloride, there was no difference between the amount of microbial inoculum and colony count. Above in vitro study indicates that tetracaine hydrochloride has no inhibitory effect on bacterial growth in short time exposure less than 2 minutes.
Agar ; Coagulase ; Staphylococcus ; Tetracaine*

The short time antibacterial effect of tetracaine hydrochloride was studied. S. aureus, Coagulase Negative Staphylococcus and P. aeruginosa were each incubated with tetracaine hydrochloride(preservative free) for 18 hours or for 2 minutes and then diluted and cultured on nutrient agar plate. Colony counts were done after 18 hours. In cases of 18 hours incubation, there was no growth of microbials in 0.5%, 0.1% tetracaine hydrochloride, but there was no inhibitory effect of 0.02% of tetracaine hydrochloride on growth of microbials, irrespective of inoculum amount. In cases of 2 minutes incubation with 0.5% tetracaine hydrochloride, there was no difference between the amount of microbial inoculum and colony count. Above in vitro study indicates that tetracaine hydrochloride has no inhibitory effect on bacterial growth in short time exposure less than 2 minutes.
Agar ; Coagulase ; Staphylococcus ; Tetracaine*

The effect of anesthetic duration of epinephrine and morphine mixture with hyperbaric tetracaine on spinal anesthesia was studied at Tague Catholic University Hospital. Fifty-two pa- tients, ASA physical status I-II, were selected randomly and divided them into 4 groups as follows: Group A; Only 0.5% hyperbaric tetracaine 14 mg injection. Group B; Mixture of 0.5% hyperbaric tetracaine 14 mg and morphine 0.15 mg injection. Group C; Mixture of 0.5% hyperbaric tetracaine l4 mg and epinephrine 0.2 mg injection. Group D; Mixture of 0.5% hyperbaric tetracaine 14 mg, morphine 0.15 mg and epinephrine 0.2 mg injection. The results of motor block onset, motor block duration, sensory block onset and sensory block duration were as follows: 1) Motor block onset; There were no statistical differences between each groups. 2) Motor block duration; The duration of motor blocks were significantly longer in group C and D than group A. The duration of motor block was significantly longer in group D than group B. 3) sensory block onset; There were no statistical differences between each groups. 4) Sensory block duration, The duration of sensory blocks were significantly longer in group D than group A, B and C. These results suggested that the effect of anesthetic duration of epinephrine and morphine mixture with local anesthetics simultaneously on spinal anesthesia were more prolonged than tetracaine injeetion only and injection of tetracaine, epinephrine mixture.
Anesthesia, Spinal* ; Anesthetics, Local* ; Epinephrine* ; Morphine* ; Tetracaine

Phenylephrine hydrochloride has been widely used in ocular theraphy and examination, such as the treatment of uveitis and glaucoma and examination of the eye ground. In this study, mydriatic action of single instillation of 10% phenylephrine hydrochloride solution was compared with that of combined instillation of 10% phenylephrine hydrochloride solution and 0.5% tetracaine drops in 110 brown eyes. The following results were obtained; 1) In 55 eyes, the diameter of the pupil reached more than 7 mm about 45 minutes after instillation of 10% phenylephrine hydrochloride solution. 2) In case of combined instillation of 0.5% tetracaine solution and 10% phenylephrine hydrochloride solution, the onset of mydriasis was delayed. 3) In the case of combined instillation of 0.5% tetracaine and 10% phenylephrine hydrochloride solution with 5 and 10 minutes interval, the action of mydriasis was acceralated. 4) After tonometry, the action of mydriasis was more acceralated.
Glaucoma ; Manometry ; Mydriasis ; Phenylephrine* ; Pupil ; Tetracaine ; Uveitis

The anesthetic properties on blockade of tourniquet pain of hyperbaric tetracaine (T-caine) and bupivacaine (marcaine) with or without epinephrine administered intrathecally were compaired in randomized study involving fourty healthy surgical patients. This investigation employed solutions of the two agents with or without epinephrine that contained equal dose (13 mg), concentration (0.5%), and volume (3ml). No statistically significant difference in height, anesthetic time, tourniquet time, tourniquet pressure, and sensory blockade level were observed between the four groups. Tourniquet pain or inadequate anesthesia did not occur in epinephrine-mix groups, But occurred in 20% of the patients in the tetracaine (t-caine) group & bupivacaine (marcaine) group each other. The results suggest that equal concentrations and dosages of hyperbaric tetracaine (T-caine) and bupivacaine (Marcaine) possessed similar anesthetic qualities on blockade of tourniquet pain following subarachnoid administration.
Anesthesia ; Bupivacaine* ; Epinephrine ; Humans ; Tetracaine* ; Tourniquets*

In an attempt to observe the influence of the spinal anesthesia on the systolic blood pressure, 350 cases of the spinal anesthesia ranging from 16 to 60 years of age were analyzed. The spinal anesthetics in this study was hyperbaric solution of 0.5% tetracaine in 6 or 10% D/W. The 350 cases were put into 4 groups by their preanesthetic systolic blood pressure and by post anesthetic dermatome of sensory block, and then the alteration of blood pressure in systolic of each group was studied. The results obtained are as follows. 1) The maximal fall of blood pressure was seen at 10 min. after spinal anesthesia. 2) Of the groups of the same sensory block dermatome, the fall of the more prominent in the higher initial systolic blood pressure group. 3) Of the groups of the same initial systolic blood pressure, the fall of was more prominent in the higher sensory block dermatome group. 4) The most prominent fall of the systolic blood pressure during spinal anesthesia was seen on the highest sensory block dermatome and initial systolic blood pressure.
Anesthesia, Spinal* ; Anesthetics ; Blood Pressure* ; Tetracaine

59 males and females were tested for the purpose of measuring the basic lacrimation under topical anesthesia of cornea and conjunctiva with 0.5% pontocaine using Toyo No.5 filter paper of 4.5 X 35mm in size. The total mean is 1.52mm/min and the means of male and female are 1.65mm/min and 1.37mm/min respectively. The mean of persons under 30 years of age is 1.68mm/min and that of over 30 years is 1.31mm/min. The means of male and female under 30 years of age are 2.12mm/min and 1.16mm/min and those of over 30 years are 1.01mm/min and 1.60mm/min respectively. The difference between means under 30 years and that of over 30 years in male is statistically significant but other differences are statistically not significant. The difference between auther's and other's values is, I suppose, derived partly from different filter paper used, and smallness of the number of person is another factor influenced.
Anesthesia ; Conjunctiva ; Cornea ; Female ; Humans* ; Male ; Tetracaine

The effect of anesthetic volume on the spread of hypobaric tetracaine were sutdied after intrathecal injection in thirty patients with prone jackknife and 15 degree Trendelenburg position for perinal surgery. The patients were assigned randomly into the one of three groups divided by the 3, 4, or 5 ml of volume of anesthetic solution. The results show that the volume of tetracaine in distilled water with hypobaric spinal anesthesia in prone jackknife and l5 degree Trendelenburg position had a important effect on the anesthetic dermatomal levels in spite of slightly rapid onset with large. volume. Therefore, we concluded that for the perianal surgery in prone jackknife position, as the volume of the anes- thetic solution with hypobaric spinal anesthesia, 3 or 4 ml of the volume are sufficient to get the adequate anesthetic levels.
Anesthesia, Spinal* ; Head-Down Tilt ; Humans ; Injections, Spinal ; Tetracaine ; Water

Under the general anesthesia the effect of topical anesthesia on the incidence of oculocardiac reflex was investigated by preoperative instillation of 0.5% tetracaine into the 48 eyes during horizontal strabismus muscle surgery. In all cases, recession was done first. The results were as followings: 1. The incidences of oculocardiac reflex in treated and control group were 33% and 71% respectively and the difference was statistically significant(p<0.025). 2. The reduction in the incidence of oculocardiac reflex was noted both in recession and resection. But there was no statistically significant difference between treated group and control group in resection. 3. The incidence of oculocardiac reflex was not related with age, sex, type of strabismus, kind of muscles and type of surgery.
Anesthesia* ; Anesthesia, General ; Incidence ; Muscles ; Reflex, Oculocardiac* ; Strabismus ; Tetracaine

Anesthetics, Local* ; Animals ; Papillary Muscles* ; Procaine ; Rats* ; Tetracaine