The functions and service of WeChat platform in domestic academic libraries were summarized in order to find out the satisfied aspects ( such as its response speed, interface design and operation) and unsatisfied aspects (interaction efficiency, push quality and popularization) of users with the functions and service of WeChat plat-form. Measures should be taken for improving the unsatisfied aspects in order to meet the users' requirements, and suggestions were put forward for optimizing the functions of WeChat platform and perfecting its service, such as atta-ching importance to the WeChat public platform construction and improving its service in order to transform the aca-demic libraries into intelligent libraries.

Female ; Humans ; Hypopharynx ; Infant, Newborn ; Pharyngeal Diseases ; pathology ; Polyps ; pathology

This paper introduced the concept of humanistic therapy and its connotation and application in the field of surgery, the spiritual essence and the docking and bioethics.The authors also analyzed the perioperative patients need humanistic therapy, including technology, ethics, psychology, the needs of the practice; discusses the humanistic therapy in clinical practice,includes:practice conditions, personnel, measures and problems.

Actins ; metabolism ; Adult ; Aged ; Carcinoma, Squamous Cell ; metabolism ; pathology ; Female ; Humans ; Laryngeal Neoplasms ; metabolism ; pathology ; Lymphatic Metastasis ; pathology ; Lymphatic Vessels ; metabolism ; pathology ; Male ; Middle Aged ; Vascular Endothelial Growth Factor C ; metabolism

Bladder tumor is the most common genitourinary tumor in Korea. Papillomatous growths of bladder submit to transurethral resection if diagnosed early but in invasive tumors there is still considerable disagreement about the proper treatment. We herein made clinical observation on 27 cases of bladder tumors during 1 year from January, 1977 to December . 1977. The results are as follows: 1. The rate of bladder tumor accounted for 5 % of total patients admitted to the Department of Urology. 2. The age distribution is between 36 and 73 years of age, showing the highest incidence in 51 to 60 years of age (37.1%) and 70.4 % of patients with bladder tumor are seen in 51 to 70 age groups. 3. The most common symptom was gross hematuria(74.1%). 4. Clinical staging was done by bimannual pelvic examination under the anesthesia, I.V.P. and cystoscopy with deep muscle biopsy. 5. Methods of treatment were operation only in 12 cases, operation followed irradiation in 11 cases, preoperative irradiation in 1 case and adriamycin instillation with irradiation in 1 case. 6. Operations were T.U.R. in 7cases, partial cystectomy in 8cases, total cystectomy with ileal conduit in 7 cases, ileal conduit with hypogastric artery ligation in 1 case and ureter ocutaneostomy in 1 case.
Age Distribution ; Anesthesia ; Arteries ; Biopsy ; Cystectomy ; Cystoscopy ; Doxorubicin ; Gynecological Examination ; Humans ; Incidence ; Korea ; Ligation ; Ureter ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; Urinary Diversion ; Urology

A Clinical study was made on 41 cases of bilateral urinary stones who were admitted to Yonsei Medical Center, Severance Hospital during the period from January, 1962 to December, 1976. The results of this study may be summarized as follows: 1. During the period the total urinary stone patients were 997 and the ineidense of bilateral stone was 4.1 %. 2. 80 percents of the patients with bilateral stones were seen in 21-50 age groups. 3. Urinary infection was complicated in 63 % and staphylococcus coagulase positive was most common. 4. Urine acidity was over than pH 75 1n 6 patients and less than pH 5.5 in 2 patients. 5. In blood chemistry hypercalcemia was revaled in 7 patients. BUN was more than 20 mg % in 10 patients and creatinine was more than 2mg % in 7 patients. 6. The most common chief complaints were flank Pain which was in 31 patients. The next was gross hematuria which was in 21 patients. Total anuria was noted in 2 patients. 7. the location of bilateral urinary stone was most common in one kidney and one ureter which was in 15 cases. 8. The excretory urography revealed mild hydronephrosis in 21 cases, marked hydronephrosis in 9 cases, nonvisualization in 4 cases, delayed visualization in 19 cases and nephrogram only in 11 cases. 9. In the past history, immobilization and trauma was seen in 1 case respectively and the remaining cases there could not be noted the specific causative factors in the stone formation. 10. Operation was done in 33cases, endoscopic management in 7 cases, and kidney bisection in two cases.
Anuria ; Chemistry ; Coagulase ; Creatinine ; Flank Pain ; Hematuria ; Humans ; Hydrogen-Ion Concentration ; Hydronephrosis ; Hypercalcemia ; Immobilization ; Kidney ; Staphylococcus ; Ureter ; Urinary Calculi* ; Urography

OBJECTIVETo observe the effect of Spleen-invigorating Prescription (SIP) on dendritic cell function in patients with chronic hepatitis B.

METHODSA total of 60 patients with chronic HBV of Pi-deficiency syndrome type were enrolled and randomized to 2 groups, 30 in each group. Patients in the control group were given intramuscular injection with human interferon alpha 1b, 3 times a week, while those in the treated group were given orally with SIP twice a day, the therapy lasted for 6 months. Dendritic cells (DCs) were isolated from peripheral blood and cultured, then the expression of surface markers, HLA-DR, CD86, CD80, CD40, CD14 and CD11c were detected before and after treatment by flow cytometry, and the function of DCs was also evaluated by mixed lymphocyte reaction (MLR) determination once before treatment and once after treatment.

RESULTSThe expressions of DCs' surface CD86, CD80, CD40 and CD11c in the treated group were higher (P < 0.05, P < 0.01) and the changes of stimulating index, IFN-gamma and IL-12 were superior in the treated group to those in the control group (P < 0.05).

CONCLUSIONSSIP can significantly improve DC's function, so, one of mechanisms of SIP in improving clinical efficacy may be the regulation of immune function.

Adult ; Antiviral Agents ; therapeutic use ; B7-1 Antigen ; analysis ; B7-2 Antigen ; analysis ; Dendritic Cells ; cytology ; drug effects ; immunology ; Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Hepatitis B, Chronic ; drug therapy ; immunology ; Humans ; Interferon-alpha ; therapeutic use ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Phytotherapy ; Syndrome ; Yang Deficiency ; drug therapy ; Young Adult

The study aims to identify the related substances in fasudil hydrochloride by hyphenated techniques. A WondaSil C18 (250 mm x 4.6 mm, 5 microm) column was used for the separation of the related substances with a mixture of methanol and ammonium acetate buffer solution as the mobile phase by gradient elution. The structures of the related substances were speculated by electrospray positive ionization LC-TOF/MS accurate ion mass and MS/MS determination and elucidation, and verified further through synthesis and spectroscopic analysis. Fasudil hydrochloride and the related substances were separated under the established HPLC condition. Three related substances in fasudil hydrochloride were characterized by hyphenated techniques. The hyphenated LC-MS method is useful for the identification of related substances in fasudil hydrochloride and the results obtained are valuable for its manufacturing process and quality control.
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine ; analogs & derivatives ; chemistry ; Calcium Channel Blockers ; chemistry ; Chromatography, Liquid ; Drug Contamination ; Quality Control ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry ; Vasodilator Agents ; chemistry

ObjectiveTo study the relationship between expression of a3 chain of collagen Ⅸ (COLIXA3)mRNA in the population exposed to fluorine and fluorosis,in order to reveal the role of COLIXA3 gene in the pathogenesis of endemic fluorosis.MethodsTwelve cases of mild drinking water-born skeletal fluorosis were selected as case groups in Regiment 123 and 128 of Xinjiang Production and Construction Corps Seven Division,6cases of healthy people living in fluorosis areas for more than 10 years as a internal control group and 6 heathly cases living in non-fluorosis areas for more than 10 years as a external control group.The expression of COLIXA3mRNA of peripheral blood lymphocyte of skeletal fluorosis patients and control groups were determined by using SYBR Green Ⅰ chimeric fluorescent method for real-time quantitative PCR.ResultsThe results of the relative expression of COLIXA3 mRNA of case group,internal control group and external control group were 2.16 ± 0.62,1.06 ± 0.09 and 1.05 ± 0.12,respectively.The COLIXA3 expression in case group was significantly higher than that of the internal control group and the external control group (all P ＜ 0.05),while the difference of COLIXA3expression between the internal control group and the external control group was not significantly different (P ＞0.05).ConclusionsFluorine contributes to the expression of COLIXA3 mRNA in peripheral blood lymphocyte,and the expression is up to 2 times higher than that of the control groups,meaning potential biomarkers.

Objective To study the COLIXA3 gene polymorphism of patients with fluorosis and to explore the pathogenesis of COLIXA3 gene in endemic fluorosis.Methods Fifty one cases of patients with drinking-water borne fluorosis were selected as the case group in Xinzhou city,Shanxi province and 28 cases of healthy people were as the control group.Dental fluorosis was detected by Dean method and skeletal fluorosis was examined by X-ray.COLIXA3 of exon 5 gene product of 103 points was amplified by PCR and the gene locus genotype was sequenced.Results Ten cases of mild dental fluorosis,14 cases of moderate dental fluorosis,15 cases of severe dental fluorosis were detected among the 51 patients.The control group was free of dental fluorosis.All the 51 cases of patients with fluorosis had varying degrees of skeletal fluorosis,mainly osteosclerosis lesions,accounting for 86.27％(44/51 ),and mild skeletal fluorosis patients were all osteosclerosis lesions,and osteosclerosis lesions and multiple skeletal lesions were found among moderate and severe skeletal fluorosis patients in the case group,while control group had no skeletal fluorosis.The differences between genotypes of frequency distribution of AA,Aa,aa of COLIXA3 of case and control groups were not statistically significant [96.08％(49/51 ),3.92％(2/51 ),0.00％(0/51) and 96.43％(27/28),3.57％(1/28),0.00％(0/28),x2 =0.94,P ＞ 0.05].ConclusionsCOLIXA3 gene polymorphism is not significantly correlated to fluorosis.