The current study aims to investigate the validated measures used to assess anxiety in Malaysia through a systematic review. The PsycINFO and MEDLINE databases, and 28 local journals were used to search for published papers in this particular area. Twenty articles met the inclusion criteria and reviewed. The results showed that majority of the studies have validated self-report inventories, rather than structured clinical interviews. The preferred measures validated were Depression Anxiety and Stress Scale, Hospital Anxiety and Depression Scale, and General Health Questionnaire-12 item. The psychometric properties of the validated measures were also reported in this review. In general, the measures have a wide range of reliability, validity, and factor structures. However, not all of the studies adhere to the standard procedures for adapting Western-based measure. The limitations of the studies under review were also being highlighted
systematic review

Background: The early stage of cancer can be asymptomatic. Thus, different strategies were utilized to increase breast screening attendance which resulted in better treatment outcomes. Therefore, this review aimed to provide evidence on the effectiveness of the different approaches of breast screening uptake in improving screening attendance. Objectives: The primary objective of this systematic review was to determine the effectiveness of the different approaches to breast screening uptake in improving screening attendance. The secondary objective was to identify the socio-geographic profile that affects the screening uptake. Methods: Online databases, such as PubMed and Cochrane Central Register of Controlled Trials, were searched for studies published between January 2010 to December 2020. This review only included comparative randomized clinical trials involving humans as the research participants. In addition, reference lists of included studies were reviewed to identify additional relevant papers. Results: The study included the review of 12 randomized controlled trials. Seven studies were conducted in a European setting, two in the United States of America, another two studies in Asia, and one study conducted in Canada. The intervention strategy to increase screening uptake were diverse in different studies. Ten of these studies used multiple strategies, while the remaining two studies utilized individualized strategies. Most of the studies were individual-based interventions. One study was a group-based intervention. The results showed that these interventions increase the uptake of breast cancer screening than no intervention at all. Conclusions The review confirmed that any interventions to increase breast screening uptake showed favorable outcomes in increasing breast screening attendance. However, the effectiveness of any one specific intervention cannot be made as these interventional studies greatly varied in terms of their intervention, study population, and geographical area.
Systematic Review

Background: Child well-being is an important outcome and has received attention from researchers for decades. Until recently, there has been difficulty in drawing conclusions from these studies because of the wide variety of measures used. Objective: This systematic review aims to summarize and assess the measurement properties of existing child well-being instruments presented in the literature. Methods: This systematic review will focus on studies that evaluated the psychometric properties of instruments to measure the well-being of children ages two to seven. The search strategy will aim to locate studies in the English language completed from 2000 to 2023. The databases to be searched include MEDLINE via PubMed, CINAHL Plus, and Psychology & Behavioral Sciences Collection via EBSCOhost. Proquest Dissertations and Theses, Google Scholar, and Research Gate will be used to search unpublished studies. Following the search, all identified citations will be collated in Mendeley. The full text of selected citations will be uploaded to JBI-SUMARI, assessed in detail against the inclusion criteria, and critically appraised using the COSMIN Risk of Bias checklist by two independent reviewers. Data will be extracted using JBI-SUMARI by one reviewer and verified by another. Findings will be reported using a narrative synthesis and tables. If possible, a meta-analysis will be performed. The evidence for each measurement property for each instrument will be compared against acknowledged standards for appropriate measurement characteristics using the COSMIN-proposed "criteria for good measurement properties." Expected Results: This systematic review will provide further evidence regarding the measurement properties of instruments used to measure the well-being of children, specifically in the early years. The findings of this study will be disseminated through a conference presentation and publication in a peer-reviewed journal PROSPERO registration number CRD4202342T8953
Systematic Review

Background: Seborrheic keratosis is a benign skin tumor removed through electrodessication, cryotherapy, or surgery. Alternative options may be beneficial to patients with contraindications to standard treatment, or those who prefer a non-invasive approach. Objectives: To determine the effectiveness and safety of topical medications on seborrheic keratosis in the clearance of lesions, compared to placebo or standard therapy. Methods: Studies involving seborrheic keratosis treated with any topical medication, compared to cryotherapy, electrodessication or placebo were obtained from MEDLINE, HERDIN, and Cochrane electronic databases from 1990 to June 2018. Results: The search strategy yielded sixty articles. Nine publications (two randomized controlled trials, two non-randomized controlled trials, three cohort studies, two case reports) covering twelve medications (hydrogen peroxide, tacalcitol, calcipotriol, maxacalcitol, ammonium lactate, tazarotene, imiquimod, trichloroacetic acid, urea, nitric-zinc oxide, potassium dobesilate, 5-fluorouracil) were identified. The analysis showed that hydrogen peroxide 40% presented the highest level of evidence and was significantly more effective in the clearance of lesions compared to placebo. Conclusion Most of the treatments reviewed resulted in good to excellent lesion clearance, with a few well-tolerated minor adverse events. Topical therapy is a viable option; however, the level of evidence is low. Standard invasive therapy remains to be the more acceptable modality.
Keratosis, Seborrheic ; Systematic Review

A systematic review summarizes the results of a number of individual studies that address a focused clinical question. It may be accompanied by a meta-analysis, which is a quantitative method of combining the results of all these studies in order to come up with a summary statistic of the overall effect of an intervention. Single studies may be unrepresentative of the total body of evidence, that is why combining the results of several studies in a systematic review increases precision, provides better estimates of effect, and includes a greater range of patients thus facilitating better clinical decision making. This must be done in a systematic and reproducible manner.
Systematic Review ; Meta-Analysis

Systematic reviews and meta-analysis combine results and analysis of data from different primary studies (e.g. cross-sectional studies, case-control studies, cohort studies) conducted on similar or related research topics. They are secondary studies that guide clinical decision-making, delivery of care and policy development. This article aims to discuss how to conduct a systematic review and meta-analysis. The steps in conducting a systematic review and meta-analysis include: 1) Identify the purpose including formulating the research question and validating the purpose of the literature scan, 2) Formulate the objectives, 3) Literature search including selection of studies based on population, intervention, comparison and outcome, 4) Retrieval of full text articles, 5) Critical appraisal of articles, 6) Data extraction, 7) Data analysis and 8) Writing the final report. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) is a useful guide in conducting and write systematic review and meta-analysis. While ethics approval is not usually required for systematic review and meta-analysis, authors of such study should still observe good practices including avoiding plagiarism, maintaining transparency and ensuring data accuracy.

BACKGROUND

Sarcopenia is a multifactorial disease with a progressive decline in skeletal muscle mass, muscle strength, and physical performance. Curcumin is a nutraceutical investigated for its anti-inflammatory and antioxidant properties. It is inexpensive, accessible, and considered a safe and practical approach to help alleviate symptoms of sarcopenia and improve muscle mass and function. Objective: This systematic review aims to obtain more conclusive evidence on the effectiveness of curcumin among adults 40 years and above with sarcopenia in improving muscle pain, strength, performance, and muscle morphology.

This systematic review aims to obtain more conclusive evidence on the effectiveness of curcumin among adults 40 years and above with sarcopenia in improving muscle pain, strength, performance, and muscle morphology.

The review will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. It will focus on any interventional studies on curcumin for adults diagnosed with sarcopenia, with the following outcomes: clinically significant improvement in pain, muscle strength and performance, quality of life, and improvement in muscle morphology. Studies completed until 2024 will be included. The databases to be searched include PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL Plus (EBSCOhost), Embase, and Web of Science. The identified citations will be collated in Zotero and uploaded to Covidence© to be assessed using the eligibility criteria and systematically reviewed by two independent reviewers. The CASP Randomised Controlled Trial Checklist will be utilized to assess the quality of the included studies.

The results will serve as a groundwork for future sarcopenia research among allied health specialists, particularly those in the field of physiotherapy - students, healthcare practitioners, and academicians (PROSPERO registration number: CRD42023448750).

Introduction: Uncontrolled hypertension can lead to increased morbidity and mortality secondary to end-organ damage. Community-based health interventions promote health changes in a community setting and have been shown to promote better and more cost-effective healthcare. Existing meta-analyses on community-based interventions in hypertension control are confined to a certain country, have high risks of bias, and have shown heterogeneous results. A gap in the applicability of these conclusions necessitates the present study Objective: Synthesize available evidence on the effectiveness of community-based interventions in addition to standard of care in the control of blood pressure among hypertensive adults. Methods: A meta-analysis of randomized and non-randomized controlled trials among hypertensive adults was conducted. A literature search from various search engines and electronic databases such as PubMed, Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, Google Scholar, Proquest, medRvix, and Grey literature was done by the investigators. Separate forest plots were generated for each desired outcome. Results: Six studies were included. The pooled estimates showed a trend in favor of community-based interventions in the control of blood pressure [RR = 0.86, 95% CI 0.62 to 1.19, p = 0.37], reduction of systolic blood pressure, reduction of diastolic blood pressure [MD = -2.52, 95% CI -3.64 to -1.28, p < 0.001] and medication adherence [RR = 0.82, 95% CI 0.72 to 0.93, p = 0.0025]. However, there was high heterogeneity across studies. Subgroup analysis showed a favorable trend with lower heterogeneity in decreasing diastolic BP in particular, among community health worker-led interventions, and those involving health education and/or physical activity Conclusions/Recommendations Adherence to the current standard of care in the management of hypertension is still advised. There appears to be a trend towards control of blood pressure with community-based interventions; and a reduction of diastolic blood pressure with interventions that are led by community health workers involving health education and/or physical activity. There is a need to empower community health workers and conduct additional studies on the specific community-based interventions targeting communities as a whole whenever resources and current health restrictions allow
Hypertension ; Systematic Review ; Meta-Analysis

BACKGROUND: Alopecia areata (AA) is an autoimmune hair disorder, with the clinical variants ophiasis and extensive variants AA totalis and universalis, having poor response to therapy. Oral steroids are used to treat the severe variants, requiring prolonged therapy, which leads to side effects while discontinuation leads to high relapse rate. Azathioprine is a steroid-sparing agent for the severe AA forms.

OBJECTIVE: To review the current evidence on the therapeutic efficacy and adverse effects of azathioprine for severe forms of alopecia areata

METHODS: Published articles utilizing azathioprine for alopecia areata were obtained until July 2018 from PubMed, MEDLINE, Cochrane Library, TRIP database, HERDIN, and Google Scholar.

RESULTS: Seven articles underwent a full-length review. Clinical variants include patchy, diffuse, steroid-resistant, reticulate, totalis, universalis, ophiasis, and sisaipho. Doses ranged from 2 to 2.5 mg/kg/day or weekly 5 mg/kg pulse therapy. Initial response ranged from 6 to 12 weeks, with almost complete resolution by 32 weeks. Response was sustained for 6 months upon discontinuation, with only 14% relapsing at 2.5 months. Adverse effects were gastrointestinal discomfort, elevated liver function tests, and myelosuppression.

CONCLUSION: There is emerging evidence on the efficacy and safety of azathioprine for the treatment of extensive forms of alopecia areata. Randomized-controlled trials are needed to evaluate its efficacy.

Background: Amyotrophic lateral sclerosis is one of the neurodegenerative disorders with very limited treatment options owing to its progressive course and diverse pathophysiology. Majority of patients succumb to death within three to five years after the onset of symptoms, mostly due to respiratory failure. This study aimed to determine the efficacy and safety of ultra-high dose methylcobalamin versus placebo among patients with early-stage amyotrophic lateral sclerosis in terms of slowing down functional decline. Methods: MEDLINE, CENTRAL, and Google Scholar databases were searched from inception up to September 23, 2023. The impact of treatments was measured by risk ratios with 95% confidence interval. The overall certainty of the evidence was evaluated using GRADE. Results: No significant difference was detected for the outcome median change in the ALSFRS-R score for the whole cohort. Post-hoc analyses showed that ultra-high-dose methylcobalamin decreased ALSFRS-R scores (p=0.003 for 50 mg and p=0.01 for all methylcobalamin groups) in a dose-responsive manner. Mean difference was 1.97 in favor of methylcobalamin (95% CI, 0.44- 3.50; P = .01). Conclusion Ultra-high dose methylcobalamin can reduce ALSFRS-R scores of patients in its early stage but the scarcity of clinical trials makes it difficult to support a robust conclusion. Ultra-high dose methylcobalamin therapy remains to be investigational.
Amyotrophic Lateral Sclerosis ; Systematic Review