Introduction: Diabetes mellitus (DM) is a disease that can cause complications in the kidneys. Centella asiatica extracts have the potential to inhibit pancreatic, liver and kidney tissue damage. This study was intended to determine the potential of C. asiatica extract in inhibiting kidney damage in an animal model of DM. Methods: Male Wistar rats were used in 5 treatment groups namely non-DM, DM, and DM with C. asiatica extract Dose 1 (250mg / kg), Dose 2 (500mg / kg) and Dose 3 (1000mg / kg). Changes in body weight, blood sugar, serum urea, kidney weight, glycosuria, and urine volume were observed in all treatment groups. Results: There were no significant differences between treatment groups on changes in blood glucose concentration, body weight, and serum ureum. However, C. asiatica treated group showed significantly lower value of urine volume, glycosuria, and kidney weight compare to those on Non-DM and DM groups. Decrease in blood glucose, although not significantly different, affects glucose urine excretion. Conclusion: C. asiatica extract has the potential to inhibit kidney damage in rats with DM through prevent the increase of urine volume, glycosuria, and kidney weight.