1.Fluorescein angiographically evident diabetic maculopathy: A review
Philippine Journal of Ophthalmology 2003;28(2):60-68
Objective: To characterize diabetic maculopathy seen in the Philippines, specifically, the associated factors, the various lesions seen on fluorescein angiography, and the visual acuity associated with these lesions Design: Descriptive study - cross sectional Participants: 127 patients (254 eyes) with diabetic retinopathy based on the fluorescein angiography done at the Eye Referral Center in 1993 Results: 116 (91.34 percent) patients have maculopathy, majority of which is bilateral (84.25 percent). Age (p=0.675), sex (p=0.357), hypertension (p=0.742), duration of diabetes (p=0.778) and myopia (p=0.742) were not significantly associated with maculopathy. However, severity of retinopathy (p=0.001) was significantly associated with it. Fluorescein angiographic findings are macular staining (83.86 percent), perifoveal capillary dropout or macular ischemia (10.76 percent), and preretinal traction and membrane (5.38 percent). Microaneurysm (72.65 percent) is the most common lesion associated with macular staining, followed by capillary leakage (4.04 percent), cystoid macular edema (3.59 percent), perifoveal capillary dropout with microaneursym (2.24 percent), and capillary with microaneursym leakage (1.34 percent). Exudates are associated with microaneurysm, perifoveal capillary dropout or their combination. Vision was found to be marginally statistically different between the normal and maculopathy group (p=0.0505). The worst vision was seen in macular ischemia and preretinal traction and membrane with mean visual acuity of 0.18 and 0.25 respectively Conclusion: Severity of the retinopathy is the only variable significantly associated with maculopathy in this study. Good vision does not necessarily indicate a normal macula. Detailed examination and fluorescein angiography regardless of duration of diabetes should be done.
Human
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Middle Aged
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Adult
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ANGIOGRAPHY
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DIABETIC RETINOPATHY
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RETINA,DISEASES
2.A comparison of retinoblastoma cases in the Philippines
Roland Joseph D. Tan ; Gary John V. Mercado ; Patricia E. Cabrera ; Paulita Pamela P. Astudillo ; Rolando Enrique D. Domingo ; Josept Mari S. Poblete ; Charmaine Grace M. Cabebe ; Adriel Vincent R. Te ; Melissa Anne S. Gonzales ; Jocelyn G. Sy ; Beltran Alexis A. Aclan ; Jayson T. So ; Fatima G. Regala ; Kimberley Amanda K. Comia ; Josemaria M. Castro ; Mara Augustine S. Galang ; Aldous Dominic C. Cabanlas ; Benedicto Juan E. Aguilar ; Gabrielle S. Evangelista ; John Michael Maniwan ; Andrei P. Martin ; Calvin Y. Martinez ; John Alfred A. Lim ; Rena Ivy Bascuna ; Rachel M. Ng ; Kevin B. Agsaoay ; Kris Zana A. Arao ; Ellaine Rose V. Apostol ; Beatriz M. Prieto
Philippine Journal of Ophthalmology 2024;49(2):106-114
OBJECTIVE
This study compared the demographics, clinical profile, treatment, and outcomes of retinoblastoma patients seen at medical institutions in the Philippines between two time periods: 2010 to 2015 and 2016 to 2020.
METHODSThis was a multicenter, analytical, cohort study using review of medical charts and databases of retinoblastoma patients seen in 11 medical institutions from 2010 to 2020.
RESULTSThere were 636 patients (821 eyes) included in this study: 330 patients were seen in 2010 to 2015 while 306 in 2016 to 2020. More cases per annum were seen in the latter timeline. The number of patients with unilateral disease was not significantly different between the two time periods (p=0.51). Age at onset of symptom, age at initial consultation, and delay in consult were also not significantly different between the two time periods (p > 0.05). Patients had significantly different distributions of intraocular grades (p < 0.0001) and systemic staging (p < 0.0001) between the two time periods. Enucleation was the most common surgical treatment performed in both timelines. There was significant difference in the status of patients based on the need for systemic chemotherapy (p < 0.01). There was significant difference in outcome between the two time periods, including the proportions of living and deceased patients.
CONCLUSIONThis study compared the most comprehensive data on retinoblastoma patients in the country. There was no improvement in early health seeking behavior based on similar age at initial consult and delay in consult. Enucleation remained the most common treatment mode as opposed to chemotherapy due to similar percentage of patients with unilateral disease, an indication for enucleation rather than chemotherapy.
Human ; Retinoblastoma ; Philippines ; Epidemiology ; Treatment ; Therapeutics