Pierre Robin Sequence commonly presents with upper airway obstruction secondary to craniofacial anomalies and can be managed with several treatment modalities. In mild cases, non-invasive postural management is a good treatment option. Prone position has been established as the posture of choice to reduce potential upper airway obstruction. We report a case of Pierre Robin Sequence with airway obstruction that did not respond to prone position but responded to supine position with slight tilting of the head.