Objective To investigate the effect of blood biochemical index and jaundice symptoms of plasma exchange on patients with severe hepatitis .Methods The clinical data of 50 severe hepatitis patients in our hospital from July 2012 to July 2013 using plasma exchange treatment were retrospectively analyzed .The patients were ana-lyzed blood biochemical changes and jaundice symptoms changes before and after treatment .Results After the treat-ment,AST,ALT,PTA,ALP,GGT,DBL,TBL,TBA and LDH were significantly decreased ,the difference was statisti-cally significant(t=7.21,7.58,4.31,11.63,10.23,8.26,4.13,16.48,7.32,all P<0.05),while TP,ALB,CHE and PA had no obvious changes;After the treatment, the jaundice symptoms of most patients disappeared or loss ,the proportion of patients with jaundice symptoms [36.0%(18/50)] was significantly lower than before the treatment (χ2 =27.06,P<0.05);The effective rate of patients with acute and subacute severe hepatitis was 70.0%(14/20), which was slightly higher than 50.0%(15/30) of patients with chronic severe hepatitis ,but the difference was not statistically significant(P>0.05).Conclusion Plasma exchange technology can effectively improve the biochemical indexes of blood of patients with severe hepatitis ,improve the symptoms of jaundice .

[Objective] To primarily explore the academic features of generations of Shanghai Cai ’s gynecological school treating uterine bleeding. [Method] Through related records of “Jiangwan Cai’s Gynecology Summary”, “Proved Recipes of General Treatment”, and following-up teachers’clinic, make study on Cai’s gynecological school’s clinical experience in treating uterine bleeding in generations and summarize the features. [Result] Cai ’s gynecological school not only paid attention to Qi and blood, searching for the primary cause of disease in treatment, regulating Chong and Ren channels, with brisk drugs, and other whole academic features, but the successors of generations also integrated and made cutthrough in inheritance, absorbed new knowledge, continually made development with respective features. Such as:4th generation Yanxianggong cleared heat at first then made warm nourishment longer; 5th generation Xiaoxianggong mostly tonified Qi and Ying and regulated and stopped bleeding; the 7th Pro. Cai Xiaosun firstly differentiated Yin and Yang, mainly sought cause, then hemostasis, afterwards applied Cai ’s periodical therapy for regulating Chong and Ren, reestablishing menstrual circle;one of the 8th successors Huang Suying director mainly uses obstruction-removing therapy in treating blood-stasis uterine. [Conclusion] Cai’s gynecological school treating uterine has obvious features, with marked cure effect, worth research and study.

Increases of platelet amount and activation are associated with tumor metastasis.Current studies reveal that platelets participate in the process of tumor metastasis via promoting immune escape,adhe-sion and angiogenesis.The direct interactions between platelets and tumor cells are also founded as an important determinant in metastasis.The functions of platelets in tumor progression and metastasis suggest that platelets could be served as new potential targets for cancer treatment.

The field of rehabilitation medicine physical therapist (PT) training and education has been relatively weak links in China, how to build a rehabilitation therapist team, we constantly explore and get a greater progress. However, most of the time is still confined to empty the contents of most theoretical level, and some basic steps and the specific contents are lacked. How to stabilize therapists team? How to position therapists? It deserves to pay more attentions.

ObjectiveTo observe the level of transforming growth factor-β1 ( TGF-31 ) in lung tissue of mice with acute lung injury induced by bleomycin. MethodsSixty Kunming male mice were randomly (random number) divided into sham operation group, model group, curcumin high dose group,medium dose group and low dose group (n =12 in each group). The models of acute lung injury were made by intratracheal instillation of bleomycin for once in the mice of model group and curcumin treated groups,and equal volume of saline was used in mice of sham operation group instead of bleomycin. Curcumin was given in doses of 200 mg· kg-1 · d-1 , 100 mg· kg-1 · d-1and 50 mg · kg-1 · d-1 to the mice of high dose group, medium dose group and low dose group, respectively 24 hours after modeling until the day before sacrifice, and the mice of sham operation group and model group were fed with equal volume of saline instead. Six mice of each group were sacrificed on the 3rd and 7th day separately for detecting lung wet to dry ratio (W/D), pathological changes of lung tissue stained with HE, and level of the transforming growth factor-β1 in the lung tissues stained with immunohistochemistry in mice of each group. Data were analyzed to express as mean ± standard deviation. -PSS11.5 statistical package was used for analysis. The comparison of the mean diversity carried out by using single factor analysis of variance. Results Morphological changes in lung tissue observed under light microscope showed that obvious morphological abnormalities,alveolar edema fluid and inflammatory cells were not found in mice of sham operation group, and lung capillaries dilated, widened alveolar septum, edema fluid and inflammatory cells infiltration in the alveolar in lung tissue were seen in mice of model group, and different degrees of pathological changes were found in mice of three curcumin treated groups, but those changes were less severe than those in mice of model group. Lung wet to dry ratio (W/D) was significantly higher in mice of model group than that in mice of sham group ( P ＜ 0. 01 ), but that in mice of three curcumin treated groups was significantly lower than that in mice of model group ( P ＜ 0. 01 ). Immunohistochemistry showed low level of TGF-β1 in lung tissue of mice in sham operation group, and the level of TGF-β1 in lung tissue of mice in model group was significantly higher than that in sham operation group ( P ＜ 0. 01 ). The level of TGF-β1 in lung tissue of mice in three curcumin treated groups was significantly lower than that in mice of model group ( P ＜ 0. 01 ),but that was still higher than that in sham group ( P ＜ 0. 01 ). ConclusionsCurcumin can inhibit the TGF-β1 in lung tissue and play a protective effect on acute lung injury induced by bleomycin, reducing the degree of lung injury. The protective mechanism may be associated with the inhibition of TGF-β1 in lung tissue.

Objective To explore the relationship between dietary factors and female breast cancer. Methods A 1∶1 matched case-control study was conducted in 175 cases with histopathological diagnosis and 175 matched controls(Apr.2004 to Jul.2005), a questionnaire about general information and dietary intakes over 10 years was used in the present investigation. Results The univariate conditional analysis showed that high intake times of fruits, vegetables and soybean food were the protective factors and the relationship between intake frequencies of fruits, vegetables and soybean food intake and breast cancer showed a dose-response manner. The multivariate analysis showed that psychological hurt was the risk factors, high vegetables and soybean food intake and more delivery times were the protective factors. Conclusion High intake times of vegetables and soybean food are the protective factors for female breast cancer.

OBJECTIVE To investigate the occupational hazard situation among medical staff and conduct effective measure and enhance the medical care.METHODS A questionnaire survey on occupational hazard had been completed among the hospitals in Fengtai District in Beijing in three years.RESULTS The rate of sharp damage of medical staff was 72.13%,from them the nurses were with highest rate(81.49%).The higher rate of sharp damage was in the operating theater(88.32%)and the surgical department(82.49%).CONCLUSIONS To assure the medical safety,we should pay more attention to the occupational hazard management.

OBJECTIVE:To improve pharmacists’ consciousness, abilities and skills on pharmaceutical services and to ensure safe and effective use of drugs in patients. METHODS: With the trainning of basic theroy, basic knowledge and basic skills for the priciple to develop technique trainning in view of pharmaceutical technicians in outpatient pharmacy, it were trained or examined by means of traditional exam and operation practice with the results analyzed. RESULTS:In the examinations of drug laws and regulations and pharmacal basic knowledge, 72.8% and 36.4% of pharmacists got excellent level respectively. In the review of prescriptions, and the use of some special drugs, pharmacists masted in sufficiency. CONCLUSIONS: The new open pharmaceutical service mode in the outpatient pharmacy calls for a higher level of expertise and skills for pharmacists, thus the training in fundamental theory, basic knowledge and essential skills are significant in our hospital.

Objective To assess the changes of serum levels of interleukin-6(IL-6) and interleukin-8 (IL-8) in pregnant women with stationary phase systemic lupus erythematosus (SLE). Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure serum IL-6 and IL-8 from 14 pregnant women with stationary phase SLE (SLE group), 12 normal pregnant women (normal pregnant group) and 12 normal non-pregnant women (group normal non-pregnant). The later two groups are set as controls. Results The IL-6, IL-8 levels in group SLE patients are (20.31?5.70) ng/L and (48.80?9.17) ng/L, significantly higher than those in normal pregnant group [IL-6, IL-8 levels are (8.40?2.49) ng/L and (21.15?5.21) ng/L, respectively, P 0.05). Conclusion Serum levels of IL-6, IL-8 may be helpful to monitor the progress of SLE during pregnancy.

Objective:To analyze the anti-infection therapy for one lung cancer patient with agranulocytosis and fever after chemo-therapy to provide pharmaceutical care and support for the rational anti-infection drug use in the patient. Methods: Clinical pharma-cists analyzed the drugs used in the patient and provided pharmaceutical care for doctors according to the examination results and diag-nosis of the patient. Results:By participating in the treatment plan, clinical pharmacists ensured the treatment for the patient was safe and effective. Conclusion:Clinical pharmacists should assist doctors in making out the treatment plan according to patients’ situation in order to promote rational drug use in clinics and reflect the value of pharmaceutical care.