1.A Case of Persistent Sciatic Artery with Arteriosclerosis Obliterans
Susumu Hosoda ; Shougo Isomura ; Akira Shiikawa
Japanese Journal of Cardiovascular Surgery 2013;42(6):462-465
Persistent sciatic artery (PSA) is a very uncommon congenital malformation. Its incidence is estimated to be 0.01-0.06%. In this article, we have described the case of 59-year-old woman presenting with a left lower limb ischemia. She had a good pulse in her femoral artery. However, no pulsation of her left popliteal, pedal and posterior tibial artery was observed. The ankle brachial index (ABI) was 1.05 on the right side and 0.65 on the left side. Preoperative angiography and CT scan showed that persistent sciatic artery had been branched from left internal iliac artery and the distal side had completely occluded. This persistent sciatic artery had no aneurysmal changes. The left superficial femoral artery was hypoplastic. Blood supply to the left peroneal artery, anterior and posterior tibial arteries by collateral arteries was detected. The left leg ischemia was diagnosed due to chronic occlusion of the persistent sciatic artery. Then, the bypass grafting was performed from the left common femoral artery to the above-knee popliteal artery using an ipsilateral reversed great saphenous vein graft. Postoperatively, ABI improved to 0.89 on the left side.
2.Concomitant Repair of Annuloaortic Ectasia, Aortic Regurgitation, and Pectus Excavatum in Marfan Syndrome
Yuki Nakayama ; Akira Shikawa ; Yoshikazu Ayusawa ; Susumu Hosoda
Japanese Journal of Cardiovascular Surgery 2010;39(2):99-103
Marfan syndrome may include cardiovascular disease co-exising with thoracic deformities. A 24 year-old man given a diagnosis of Marfan syndrome and annuloaortic ectasia (AAE), aortic regurgitation (Ar) and pectus excavatum, was referred to our hospital due to the rapid dilatation of a root aneurysm. Chest computed tomography showed a root aneurysm measuring about 60×55 mm in diameter with mild Ar. Moreover, the sternum, which had been displaced in a posterior direction, contacted with the root aneurysm and heart. The heart was deviated to the left, because of compression from the sternum. We performed a concomitant repair of AAE and Ar and pectus excavatum with partial sternal turnover and elevation, and Bentall procedure. First, median skin incision was made, and dissected to the sternum. The ribs and cartilage below the third rib were cut, and the sternum was transected at the two-thirds point. The root aneurysm and heart were visible so it was easier to operate than a post median sternotomy. A cardiopulmonary bypass was established by ascending aortic perfusion, right atrial drainage and pulmonary arterial venting. The Bentall procedure was done using a Carrel patch methods. The removed sternum was formed flat and turned over, and sternum elevation was perfomed using sternal wire, after cutting and removing the excess ribs and costal cartilage. The postoperative course was uneventful with good hemodynamic and respiratory function. Concomitant surgery provides good operative exposure, which can avoid accidental aneurysm laceration, although operation time is longer and operative invasion and bleeding are greater than in staged operations.
3.Report on Group Study about Audio-visual Teaching Technology
Shigeru HAYASHI ; Kenichi UEMURA ; Nobutaka DOBA ; Masahiko HATAO ; Motokazu HORI ; Kazumasa HOSHINO ; Saichi HOSODA ; Hitoshi ISHIKAWA ; Tsutomu IWABUCHI ; Taketoshi SUGIYAMA ; Susumu TANAKA ; Yasuyuki TOKURA
Medical Education 1983;14(3):209-213
5.Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?
Tsukasa Yoshida ; Susumu Hijioko ; Waki Hosoda ; Nobumasa Mizuno ; Kazuo Hara ; Hiroshi Imaoka ; Vikram Bhatia ; Masahiro Tajika ; Mohamed A Mekky ; Makoto Ishihara ; Tatsuji Yogi ; Kenji Yamao
Innovation 2014;8(4):124-125
Background: The WHO classified pancreatic neuroendocrine neoplasms (pNEN)
in 2010 as G1, G2, and neuroendocrine carcinoma (NEC), according to Ki67
labeling index (LI). However, the clinical behavior of NEC is still not fully studied.
We aimed to clarify the clinicopathological and molecular characteristics of
NECs.
Methods: We retrospectively evaluated the clinicopathological characteristics,
KRAS mutation status, treatment response, and the overall survival of eleven
pNEC patients diagnosed between 2001 and 2014 according to the WHO 2010.
We subclassified WHO-NECs into well-differentiated (WDNEC) and poorlydifferentiated
NEC (PDNEC), the latter further subdivided into large and small
cell type.
Results: The median Ki67 LI was 69.1% (range, 40% - 95%) and the median
tumor size was 35 mm. 11 WHO-NECs were subclassified 4 WDNEC and 7
PDNEC, and further separated PDNEC into 3 large cell and 4 small cell subtypes.
Comparisons of WDNEC vs. PDNEC revealed hypervascularity on CT, 50% (2/4)
vs. 0% (0/7) (P = 0.109); median Ki67 LI, 46.3% (40% - 53%) vs. 85% (54% -
95%) (P = 0.001); KRAS mutations, 0% (0/4) vs. 85.7% (6/7) (P = 0.015); response
rates to platinum-based chemotherapy, 0% (0/2) vs.100% (4/4) (P = 0.067) and
median survival, 227 vs. 186 days (P = 0.227).
Conclusions: The WHO-NEC category may be composed of heterogeneous
disease entities, namely WDNEC and PDNEC. These subgroups tended to exhibit
differing Ki67 and KRAS mutation profiles, and distinct response to chemotherapy.
Further studies for the re-evaluation of the current WHO 2010 classification is
warranted.
6. Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?
Tsukasa YOSHIDA ; Susumu HIJIOKO ; Waki HOSODA ; Nobumasa MIZUNO ; Kazuo HARA ; Hiroshi IMAOKA ; Vikram BHATIA ; Masahiro TAJIKA ; Mohamed A Mekky ; Makoto ISHIHARA ; Tatsuji YOGI ; Kenji YAMAO
Innovation 2014;8(4):124-125
Background: The WHO classified pancreatic neuroendocrine neoplasms (pNEN)in 2010 as G1, G2, and neuroendocrine carcinoma (NEC), according to Ki67labeling index (LI). However, the clinical behavior of NEC is still not fully studied.We aimed to clarify the clinicopathological and molecular characteristics ofNECs.Methods: We retrospectively evaluated the clinicopathological characteristics,KRAS mutation status, treatment response, and the overall survival of elevenpNEC patients diagnosed between 2001 and 2014 according to the WHO 2010.We subclassified WHO-NECs into well-differentiated (WDNEC) and poorlydifferentiatedNEC (PDNEC), the latter further subdivided into large and smallcell type.Results: The median Ki67 LI was 69.1% (range, 40% - 95%) and the mediantumor size was 35 mm. 11 WHO-NECs were subclassified 4 WDNEC and 7PDNEC, and further separated PDNEC into 3 large cell and 4 small cell subtypes.Comparisons of WDNEC vs. PDNEC revealed hypervascularity on CT, 50% (2/4)vs. 0% (0/7) (P = 0.109); median Ki67 LI, 46.3% (40% - 53%) vs. 85% (54% -95%) (P = 0.001); KRAS mutations, 0% (0/4) vs. 85.7% (6/7) (P = 0.015); responserates to platinum-based chemotherapy, 0% (0/2) vs.100% (4/4) (P = 0.067) andmedian survival, 227 vs. 186 days (P = 0.227).Conclusions: The WHO-NEC category may be composed of heterogeneousdisease entities, namely WDNEC and PDNEC. These subgroups tended to exhibitdiffering Ki67 and KRAS mutation profiles, and distinct response to chemotherapy.Further studies for the re-evaluation of the current WHO 2010 classification iswarranted.
7.A Surgical Case of Infective Endocarditis Complicated by Severe Valvulare Regurgitation and Coronary Artery Embolism in Which Cardiogenic Shock Occurred before Surgery
Atomu HINO ; Susumu HOSODA ; Takeshi KATSUBE ; Akira SHIIKAWA
Japanese Journal of Cardiovascular Surgery 2019;48(1):47-50
A 45-year-old woman with moderate mitral regurgitation due to mitral valve prolapse developed respiratory discomfort after cellulitis and visited our hospital. Electrocardiogram showed ST elevation in V2, V3, V4 and serum creatinine kinase was high. Transthoracic echocardiogram revealed large mitral and aortic vegetation with severe valvular regurgitation and anterior wall motion asynergy. On computed tomography and magnetic resonance imaging, splenic infarction and right renal infarction cerebral infarction on right sided frontal white matter (1 cm in diameter) was revealed. These findings led to a diagnosis of acute heart failure due to severe regurgitation and coronary artery embolism with infective endocarditis, thus we performed an emergency cardiothoracic surgery. After general anesthesia, she suffered severe hypotension despite the injection of a high dose of catecholamine, then developed persistent ventricular tachycardia. We started cardiopulmonary resuscitation, and percutaneous cardiopulmonary support. After obtaining stable hemodynamic status, we performed surgery. The intraoperative examination showed vegetation (2 cm in diameter) on each aortic cusp, large vegetation on the anterior and posterior mitral leaflet, rupture of the posterior leaflet choreae tendineae, and vegetation on the wall of the left atrium. We performed maximal possible debridement of the infected tissue. Subsequently, we performed mitral valve replacement and aortic valve replacement, tricuspid annuloplasty. We finished surgery without cardiopulmonary support. After tight control, the patient was discharged on the 52nd postoperative day. The patient showed no recurrence of infection during 9 months of follow-up. Cases of coronary embolism with infective endocarditis are rare and have high mortality, and their treatment is still controversial.