Objective To study the effect of pronase to improve the nasogastric tube obstruction.Methods 52 patients with nasogastric tube obstruction were randomly divided into pronase group and routine treatment group. The effect to improve nasogastric tube obstruction was observed.Results The total effective rate of the pronase group (92.3%)was significantly higher than the routine treatment group(69.2%)(χ2 =11.60,P <0.01).Conclusion The effect of pronase to improve the nasogastric tube obstruction is better than the routine treatment.