1.Effects of RNA on anti-hepatic-fibrosis in rat
Shusen LING ; Suqin LI ; Pengxiang ZHU
Chinese Pharmacological Bulletin 1986;0(04):-
Hepatic fibrosis in rat induced by intraperitoneal injection of dimethylnitroamine (DMN) was traeted by RNA (4 mg ? kg-1) and CoQ10(2. 5 mg ? kg-1) ,seperately. Normal and pathological groups were compared. In 30, 60 and 90 days treatment, rats were killed for ul-trastructural examination and measurement of serum enzymology, serum amino acids and the quantity of collagenous fibers. The results indicated that, in RNA-treated and CoQ10 treated groups, Aspartate aminotransferase (AST) and Y-glutamyl-transpeptidase(?-GT) were normal, the ratio of albunm to globulin (A/G) had significantly difference compared with controlgroup. In RNA-treated group,L-Alanine:2-Ox-oglutarate Aminotransferase(ALT), monoamine oxidase (MAO) and N-acetyl-?-glucosaminidase (NAG) decreased evidently, serum amino acids increased slightly. Ultrastructural and microscopical examination showed the degree of hepa-tocytic necrosis degeneration and the quantity of collagenous fibers in RNA-treated group were rather mild. It appeared that there were protection effects of RNA on liver enzymology and hepaticfibrosis.
2.Investigation of Factors Related to Depression in Retired Elder Army Officers
Suqin REN ; Shaoyun ZHU ; Xiyun GUO ; Xiaoqing JIA ; Xuemei LI
Chinese Journal of Rehabilitation Theory and Practice 2007;13(5):497-498
Objective To investigate the factors related to the depression in the retired old army officers in Beijing, to establish effective nursing intervention on these factors. Methods Various factors related to depression were investigate using questionnaire in 500 retired army officers. Results Among 500 subjects, 23.0% (115/500) were with minor depression, 6.4% (32/500) with moderate depression, while 1.6% with severe depression. Subjects whose wife were still alive had much less incurrence rate of depression than ones remarried or widowed. The less time after retirement and less satisfaction in life were other important factors related to depression. Conclusion Psychological care should be emphasized on widowed, freshly retired, or people feeling less satisfactory in life. Active nursing intervention should be applied to lower the harmful effect of depression on health.
3.Determination of ecdysterone in Radix Achyranthis Bidentalae by near-infrared diffuse reflectance spectroscopy
Yan BAI ; Zhenxi YU ; Suqin SUN ; Fengyun ZHU ; Dong WANG ; Zhihong CHEN
Chinese Traditional and Herbal Drugs 1994;0(09):-
Objective To determine ecdysterone content in Radix Achyranthis Bidentalae by near-infrared diffuse reflectance spectroscopy (NIRDRS) combined with partial least squares (PLS). Methods NIRDRS and PLS. Results The correlation coefficient of the quantitative mathematics model between the prediction and the true values was 0.948 9. It is feasible to appling the above established method to determination of chemical constituents in Chinese materia medica. Conclusion Compared with other methods, the method is simple, rapid, high efficient, low expenditure, no pollution and with preparation undone and is suit for large quantity of unknown samples.
4.Residual Hearing after Cochlear Implantation in Children
Lei CAI ; Qingquan HUA ; Yongmao CAO ; Kun YANG ; Suqin ZHU ; Wei CHANG ; Jun LI
Journal of Audiology and Speech Pathology 2014;(5):510-513
Objective To study the influence of cochlear implantation on residual hearing in children .Methods Behavioral audiometry were performed pre -implant and 3~21 months post -implant on thirty -four cochlear implant recipients with severe to profound hearing loss .According to follow -up time ,they were divided into 2 groups which were Group A(3~12 months ,21 cases) and Group B(≥13 months ,13 cases) .The thresholds at 250 Hz ,500 Hz ,1 000 Hz and 2 000 Hz were analyzed .Results There were 25 out of 34 patients (73 .53% ) had partial residual hearing after cochlear implantation .Comparing to the hearing loss pre -operation and post -operation , which were most obvious at 500 Hz ,followed by 250 Hz ,1 000 Hz ,2 000 Hz (P<0 .05) ,and there were significant different among different frequencies .There was significant difference at different frequencies at hearing loss thresh-olds only in Group A .But there was no significant difference in Group B .With the prolonged time after the cochlear implantation ,residual hearing at all frequencies showed a trend of recovery .Conclusion The residual hearing could be partial preserved after cochlear implant in pediatric patients with severe to profound hearing impaired ,the residu-al hearing at lower frequencies (250 Hz ,500 Hz) were less affected than those at higher frequencies .With the pro-longed time after the cochlear implantation ,the residual hearing showed a certain degree of recovery .
5.The exploration of experimental pathology teaching under the idea of translational medicine
Li FENG ; Weibin CHEN ; Lan ZHU ; Ying SUN ; Aiping WU ; Suqin ZHENG
Chinese Journal of Medical Education Research 2014;13(10):1006-1008
The basic medicine teaching must meet the clinical application,while the clinical practice should be timely feedback to basic medical teaching,which is the embodiment of the idea in the translational medicine.The experimental teaching is an important part of modern pathology teaching.We actively improve the experiment course and deepen the basic concept of translational medicine in the medical education development by adopting such approaches as using the problem-based learning method(PBL) to promote the link between basic courses and clinical pathology,integrating and optimizing the teaching content to promote the knowledge mastery and conducting molecular pathology research to promote the implementation of translational medicine.
6.Treatment results of nasopharyngeal carcinoma : a retrospective analysis of 1837 cases in a single institute
Yunsheng GAO ; Chaosu HU ; Hongmei YING ; Guopei ZHU ; Lin KONG ; Xiayun HE ; Tingting XU ; Xiaoshen WANG ; Jing YUAN ; Suqin WU ; Youwang ZHANG ; Taifu LIU
Chinese Journal of Radiation Oncology 2008;17(5):335-339
Objective To summarize our experience and treatment results of nasopharyngeal carcinoma treated in a single institution. Methods From Jan. 2000 to Dec.2003,1837 patients with histologically proven nasopharyngeal carcinoma(NPC) were retrospectively analyzed. The disease was staged according to the Fuzhou stage classification. 885 patients received cisplatin (DDP) based chemotherapy. All patients received radiotherapy to the nasopharynx and neck. The dose was 30.6-74.0 Gy, 1.8-2.0 Gy per fraction over 3.5-8.0 weeks to the primary site with 60Co γ rays or 6 MV X-rays. The dose to lymph nodes was 60-68 Gy. The residual disease was boosted by 192Ir afterloading brachytherapy,small external beam fields, conformal radiotherapy,or X-knife. Results The median follow-up time was 54(3-90) months. The 5-year overall survival(OS), disease-free survival (DFS), relapse-free survival (RFS) and distant metastasis free survival(DMSF) rates were 67.42% ,63.25% ,86.47% and 80.31% ,respectively. Clinical stage was the most significant prognostic factor,and OS was 88% ,74.8% ,65.9% ,52.4% and 20% for stage Ⅰ ,stage Ⅱ,stage Ⅲ,stage ⅣA and stage ⅣB,respectively. Gender,T,N and TNM stage were the significant prognostic factors of OS in multivariate analysis. Conclusions For NPC patients,the 5-year OS of 67.4% is achieved by conventional radiotherapy technique in our institution. Both univariate and multivariate analysis shows that gender and clinical stage are the significant prognostic factors of OS.
7.Study on the relationship between the opacity of lens and the levels of 2, 6-dinitro-4-amino-toluene (DNAT) in the urine of workers exposed to trinitrotoluene(TNT).
Zhongde ZHU ; Zhilan LI ; Fatai MI ; Suqin LIAN ; Pengcheng DONG ; Yuhua WU ; Xiaohua SUN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2002;20(1):42-43
OBJECTIVETo find out the relationship between the opacity in lens and the contents of 2,6-dinitro-4-amino-toluene(DNAT) in the urine of exposed workers.
METHODSTesting the exposed worker's lens and measuring the contents of DNAT in the urine after work.
RESULTSWhen the opacity of the lens occurred, the contents of DNAT in the urine(2.38 mg/L) of workers exposed to TNT were significantly higher than those without opacity in lens(1.44 mg/L) (P < 0.05).
CONCLUSIONThe severity of opacity of lens increased with the contents of DNAT raised in the urine. The threshold value suggested by ILO is not applicable to Chinese occupational population, which recommends the contents of DNAT(30 mg/L) in the urine for the workers exposed to TNT as biological occupational exposed limits.
Aniline Compounds ; urine ; Cataract ; chemically induced ; Environmental Monitoring ; Humans ; Occupational Exposure ; adverse effects ; Trinitrotoluene ; metabolism
8.Calcium-sensing receptor-mediated L-tryptophan-induced secretion of cholecystokinin and glucose-dependent insulinotropic peptide in swine duodenum
Xiuying ZHAO ; Yihan XIAN ; Chao WANG ; Liren DING ; Xianglong MENG ; Weiyun ZHU ; Suqin HANG
Journal of Veterinary Science 2018;19(2):179-187
This study aimed to elucidate the effect of tryptophan (Trp) on gut hormone secretion as well as the roles of the calcium-sensing receptor (CaSR) and its downstream signaling pathway in gut hormone secretion by assessing swine duodenal perfusion in vitro. Swine duodenum was perfused with Krebs-Henseleit buffer as a basal solution. Various concentrations (0, 10, and 20 mM) of Trp were applied to investigate its effect on gut hormone secretion. A CaSR antagonist was used to detect the involvement of CaSR and its signal molecules. The 20 mM Trp concentration promoted the secretion of cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP), elevated the mRNA level of CaSR, and upregulated the protein levels of CaSR, protein kinase C (PKC), and inositol trisphosphate receptor (IP3R). However, NPS 2143, an inhibitor of CaSR, attenuated the CCK and GIP release, reduced the mRNA level of CaSR, and decreased the protein levels of CaSR, PKC, and IP3R with 20 mM Trp perfusion. The results indicate that CCK and GIP secretion can be induced by Trp in swine duodenum in vitro, and the effect is mediated by CaSR and its downstream signal molecules PKC and IP3R.
Cholecystokinin
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Duodenum
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Gastric Inhibitory Polypeptide
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In Vitro Techniques
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Inositol
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Perfusion
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Protein Kinase C
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Receptors, Calcium-Sensing
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RNA, Messenger
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Swine
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Tryptophan
9.The investigation for the neuropeptides of nasal septum in perennial allergic rhinitis patient.
Qiubei ZHU ; Suqin ZHANG ; Jingxian WU ; Haihong TANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;23(8):339-342
OBJECTIVE:
To investigate the expression of neuropeptides in the nasal septum of the perennial allergic rhinitis patients, and the mechanism of the alleviation effect of nasal septum rectification to allergic rhinitis.
METHOD:
Forty-five patients with deviation of nasal septum (20 with allergic rhinitis and 25 without), who undergone nasal septum rectification in Changhai hospital during Jun to Dec, 2007, were included in this research. The levels of SP, VIP, CGRP of the nasal septum were determined by radioimmunoassay.
RESULT:
In the normal controls, the SP, VIP and CGRP levels of the nasal septal cartilages were lower than that of the nasal septal bones (P<0.05), while in the perennial allergic rhinitis patients group, there were no statistical significance between the SP, VIP levels of the nasal septal cartilages and that of the nasal septal bones (P>0.05), and the CGRP level of the nasal septal cartilages was higher than that of the nasal septal bones (P<0.05). The SP, VIP levels of the nasal septal cartilages in the perennial allergic rhinitis patients group were higher than that in the normal controls (P<0.05), and there were no statistical significance between the levels of the nasal septal bones in the two groups (P>0.05). There were no statistical significance between the CGRP levels of the nasal septal cartilages in the two groups (P>0.05), neither did that of the nasal septal bones in the two groups (P>0.05).
CONCLUSION
The SP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. The VIP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. There were no statistical significance between the CGRP levels of the nasal septum in the perennial allergic rhinitis patients and the normal controls.
Calcitonin Gene-Related Peptide
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metabolism
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Case-Control Studies
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Humans
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Nasal Mucosa
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metabolism
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Nasal Septum
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metabolism
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Rhinitis, Allergic, Perennial
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metabolism
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Substance P
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metabolism
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Vasoactive Intestinal Peptide
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metabolism
10.Effects of Olmesartan Medoxomil on Cardiac Function,Plasma NT-proBNP and Serum IL-23 in Patients with Chronic Heart Failure
Suqin ZHOU ; Jiayi TONG ; Congfei ZHU ; Yawei LI ; Lanlan ZHOU
China Pharmacy 2017;28(29):4126-4129
OBJECTIVE:To investigate the effects of olmesartan medoxomil on cardiac function,plasma N-terminal pro-brain natriuretic peptide(NT-proBNP)and serum interleukin-23(IL-23)in patients with chronic heart failure(CHF),and to evaluation its safety. METHODS:A total of 40 CHF patients selected from Lianshui County People's Hospital of Jiangsu Province during Dec. 2014-May 2016 were divided into control group and observation group according to random number table,with 20 cases in each group. Control group was given Enalapril maleate tablets with initial dose of 5 mg,po,qd(increasing gradually after one week,limiting dose of 20 mg/d)+Metoprolol tartrate tablets 25 mg,po,bid+Isosorbide mononitrate tablets 40 mg,po,qd+Furose-mide tablets 20 mg,po,bid. Observation group was additionally given Olmesartan medoxomil tablets 20 mg,po,qd,on the basis of control group. Both groups received treatment for consecutive 8 weeks. Cardiac function indexes [LVEDD,LAD,IVST,LVP-WT,LVEF,early diastolic peak E filling velocity/late diastolic peak A filling velocity(E/A)],plasma NT-proBNP and serum IL-23 levels were observed in 2 groups before and after treatment. The incidence of ADR was recorded. RESULTS:Before treat-ment,there was no statistical significance in cardiac function indexes,plasma NT-proBNP or serum IL-23 levels between 2 groups (P>0.05).After treatment,LVEDD,LAD,plasma NT-proBNP and serum IL-23 levels of 2 groups were decreased significantly, while LVEF and E/A levels were increased significantly;the observation group was significantly better than control group,with sta-tistical significance(P<0.05). There was no statistical significance in IVST or LVPWT levels between 2 groups before and after treatment,and there was no statistical significance in the incidence of ADR between observation group(25.00%)and control group(20.00%)(P>0.05). CONCLUSIONS:Olmesartan medoxomil can decrease the levels of plasma NT-proBNP and serum IL-23 in CHF patients,and improve cardiac function with good safety.