〔Abstract〕 The paper discusses the basic concept , pattern and implementation methods of the semantics -based electronic health re-cords information organization and points out the electronic health records is the basis for realizing the community medical health service network system .The fundamental objective of the electronic health records information organization is to serve the vast information con -sumers, producers and transmitters .

Since 1980s,the ultrasonography has been applied to diagnose cruciate ligament injury of the keen joint and undergone continuous development.At present,cruciate ligament injury of the keen joint can be diagnosed by many examination methods,such as X-ray,arthroscopy,magnetic resonance and ultrasonography.X-ray and arthroscopy are invasive.Magnetic resonance is accurate,but expensive.Ultrasonography could clearly display the anatomic and damaged structure of the cruciate ligament.Ultrasonography is an economical,practical,and noninvasive diagnostic method,and it is valuable in diagnosis of the injured cruciate ligamengt of the knee joint.This manuscript comprehensively analyzes the development of functional anatomy,biomechanics,clinical manifestation,type of damage and imaging features of the injured cruciate ligamengt of the knee joint.The imaging examination of posterior cruciate ligament used by high-frequency and low-frequency ultrasound is valuable for diagnosis of injured anterior cruciate ligament.

As a treatment of noninvasive,safe,effective,and easy to operate,external counterpulsation has been widely used in the treatment of ischemic heart disease.The treatment mechanism of external counterpulsation may improve collateral circulation and hemodynamics.Therefore,it can provide a new measure for the treatment of cerebrovascular disease.However,the efficacy and safety of external counterpulsation in the treatment of ischemic stroke still need to be confirmed by a large sample clinical trial.

Objective To evaluate the accuracy of spectral entropy including response entropy(RE)and state entropy(SE)as a new electroencephalographic measure of depth of sedation during general anesthesia.Methods Twenty ASA Ⅰ or Ⅱ patients aged 20-55 yr undergoing elective abdominal surgery were studied.Anesthesia Was induced with intravenous propofol,fentanyl and vecuronium.After tracheal intubation anesthesia was maintained with sevoflurane inhalation and intermittent iv boluses of fentanyl and vecuronium.BP,HR,SpO2,spectral entropy(Datex-Ohmeda)and BIS(Aspect Medical)were monitored during anesthesia.Loss of eyelash reflex and unresponsiveness to verbal stimulus and mild prodding and shaking were considered to be signs of loss of consciousness(LOC).The time of regaining consciousness Was defined as the time when patients started responding to verbal commands.RE,SE and BIS were recorded before anesthesia(baseline),10 min before LOC,immediately after LOC,immediately after tracbeal intubation,1 h after skin incision,10 min before regaining consciousness immediately after consciousness was regained and 10 min after extubation.Results There were sisnificant changes in RE,SE and BIS during the transition from consciousness to LOC.The RE,SE and BIS values for LOC were 76,73 and 68 with sensitivity of 94%,95%and 92%and specificity of 92%,94%and 91%respectively.The accuracy of RE.SE and BIS in predicting LOC was 93%,95%and 94%respectively.The RE,SE and BIS values for regaining consciousness were 82,75 and 70 with sensitivity of 95%,95%and 91%and specificity of 93%,96%and 93%respectively.The accuracy in predicting regaining of consciousness was 98%,96%and 97%respectively.Conclusion Entropy index Can accurately monitor level of sedation during general anesthesia.

BACKGROUND:There are many reports on the effects of low-to-moderate intensity endurance exercise on mitochondrial biogenesis in the skeletal muscle, but there is no understanding about the high-intensity endurance exercise. It has not been reported whether the high-intensity endurance exercise influence the mitochondrial biogenesis in the skeletal muscle through 5′-adenosine monophosphate-activated protein kinase (AMPK)/silent information regulator factor 2 related enzyme 1 (SIRT1) signal molecules. OBJECTIVE: To investigate the effect of AMPK/SIRT1 signaling cascade on the mitochondrial biogenesis in the skeletal muscle during different intensities of endurance exercises. METHODS:Forty-two male Sprague-Dawley rats were randomly divided into sedentary group, moderate-intensity exercise group and high-intensity exercise group. Moderate-intensity exercise load was 28 m/min, 60 min/d;high-intensity exercise load was 38 m/min, 60 min/d. In both exercise groups, the rats had 5 days of exercise and 2 days of rest within 1 week, and the exercise lasted for totaly 7 weeks. The animals of exercise groups were kiled immediately, 6 hours and 24 hours after exercise. Quantitative PCR was used to detect peroxisome proliferators γ activated receptor coativator-1α (PGC-1α) and SIRT1 gene expression, and western blot to detect phosphorylated-AMPK (P-AMPK) and SIRT1 protein expression. RESULTS AND CONCLUSION:(1) Immediately, 6 hours, 24 hours after moderate-intensity exercise, PGC-1α mRNA expression in the skeletal muscle was 362% (P < 0.01), 675% (P < 0.01) and 116% of that in the sedentary group, P-AMPK protein expression was 112%, 165% (P < 0.05), 129% (P < 0.05) of that in the sedentary group, the expressions of SIRT1 protein and mRNA were 55% (P < 0.05), 86%, 103% and 109% (P < 0.05), 155%, 132% (P < 0.05) of those in the the sedentary group, respectively. (2) Immediately, 6 hours, 24 hours after high-intensity exercise, PGC-1α mRNA expression in the skeletal muscle was 274% (P < 0.01), 130% (P < 0.05), 68% (P < 0.05) of that in the sedentary group, the expression of P-AMPK protein was 235% (P < 0.01), 166% (P < 0.05), 160% (P < 0.05) of that in the sedentary group, the expressions of SIRT1 protein and mRNA were 199% (P < 0.01), 166% (P < 0.05), 164% (P < 0.05) and 255% (P < 0.01), 292% (P < 0.01), 122% of those in the sedentary group, respectively. These findings indicate that (1) 7 weeks of moderate-intensity endurance exercise significantly increased PGC-1α gene expression in the skeletal muscle, and its mechanism may involve AMPK/SIRT1 signaling cascade; (2) 7 weeks of high-intensity endurance exercise significantly inhibited PGC-1α gene expression at 24 hours after exercise,and this process was carried out in an AMPK/SIRT1 signal cascade independent manner.

Background and purpose:Cisplatin-based concurrent chemoradiotherapy(CCRT) has become the standard treatment for locally advanced cervical cancer(LACC) . But no marked survival benefi t was found for stage Ⅲ-ⅣA patients,and the high toxicity of cisplatin warrants evaluation of other chemotherapeutic agents to increase effi cacy and decrease toxicity. This study was done to evaluate the effi cacy and toxicity of paclitaxel(TXL) and nedaplatin(NDP) administered concurrently with radiotherapy followed by consolidation chemotherapy in the treatment of locally advanced squamous cell cervical carcinoma(LASCC) . Methods:29 Patients with LASCC(FIGO stage ⅡB-ⅢB) were enrolled into this study from February 5,2007 through December 10,2007. The median age was 48 years old(35-64) . Radiotherapy included external beam radiotherapy to pelvic(stageⅡB 45Gy,stage Ⅲ 50 Gy) and 192Ir brachytherapy(stageⅡB 50 Gy,stage Ⅲ 35Gy) . TXL 35 mg/m2 and NDP 20 mg/m2 were given every week for 6 weeks concurrently with radiotherapy. After one month of CCRT,TXL 135 mg/m2 and NDP 60mg/m2 were administered every 3 weeks for 4 cycles. Results:All patients completed CCRT. For the consolidation chemotherapy,25 patients received 4 cycles,2 patients 3 cycles and 2 patients 2 cycles. The clinical complete response rate was 89.7%(95%CI,78.6%-100%) ,partial response rate 10.3%(95%CI,0-21.4%) After a median follow-up of 14 months(range,8.7-18.8 months) ,the disease-free and overall survival rates were 86.2%(95% CI,73.7%-98.7%) and 96.7%(95% CI 90.2%-100%) ,respectively. One patient died due to disease progression.During CCRT,Grade 3 leukopenia occurred in 3.6%(6/169) of the cycles,Grade 3 diarrhea 0.6%(1/169) ;During consolidation chemotherapy,Grade 3 leukopenia and neutropenia occurred in 8.7%(9/104) of the cycles. There were 2 patients who developed Grade 3 late rectum toxicity. Conclusion:CCRT with paclitaxel and nedaplatin followed by consolidation chemotherapy is well tolerated and effective in patients with LASCC. A prospective randomized trial to compare this treatment strategy with standard CCRT seems to be worthwhile.

Objective:To explore the relationship among procrastination behavior,meta -cognitive and emotion of university students.Methods:A total of 468 undergraduates from 4 universities were surveyed by GPS,PANAS and MCQ-30.Results:①The undergraduates from liberal arts colleges reported more procrastination behavior than those from science colleges.② Cognitive confidence,positive beliefs,uncontrollability/danger,tendency to control thoughts,and negative emotion positively correlated to procrastination behavior;cognitive self-consciousness and positively emotion negatively correlated to procrastination behavior.③ Cognitive confidence,uncontrollability/danger and negative emotion could positively predict procrastination behavior.④Negative emotion mediated the relationship between uncontrollability/danger and procrastination behavior.Conclusion:Uncontrollability and danger are a significant predicator of procrastination behavior,and negative emotion has a significant mediation effect on the relationship between uncontrollability/danger and procrastination behavior.

Objective To analyze the main causes of sources of stress for nurses in cardiovascular department. Methods We selected 110 nurses from three class-one hospitals in Chengdu and divided them into the nurses in cardiovascular department (the research group) and nurses in other departments (the control group). We compared the two groups in the following aspects: family, society, interpersonal relationship, work nature and work strength, continuing education and professional demand. In view of the high spirit stress existed in nurses in cardiovascular department, some corresponding stress-relief strategies were adopted. Results Two groups were statistically different in social, interpersonal relationship, work nature and work strength, continuing education and professional demand. While in the aspect of family, no difference was seen. Conclusions nurses in cardiovascular department had high spirit stress in social, interpersonal relationship, work nature and work strength, continuing education and professional demand. To analyze sources of stress and stress-relief strategy for them could improve physical and psychological health of them and thus enhance nursing quality.

Endostatin is an antitumor molecular targeting angiogenesis of tumor and plays an inhibitory role in tumorigenesis through inhibiting pathological angiogenesis, proliferation and metastasis of tumor. As increasing drugs for targeting therapy aim in clinic, endostatin has become one of hot spots of research on combined treatment of cancer in recent years.

Objective To observe the effect of Chinese medicine of Gukang(GK) on bone mineral density(BMD) in osteoporosis rats.Methods Seventy-two female SD rats were randomized into 6 groups: pseudo-operation group,model group,nilestriol group(in the dose of 1mg/kg),and high-,middle-and low-dose GK groups(9.6,4.8 and 2.4 g?kg-1?d-1 respectively).Rat models of osteoporosis were induced by removal of bilateral ovaries.Three months after operation,the rats were given the corresponding medicine according the experimental design.After treatment for 3 months,in-vivo BMD as well as the in-vitro BMD in the isolated left femur and tibia was detected with dual energy X-ray bone densitometer.Results The in-vivo general BMD and lumbar BMD of the model group were decreased(P