No abstract available.
Superoxide Dismutase* ; Superoxides*

No abstract available.
Animals ; Rats* ; Superoxide Dismutase* ; Superoxides*

There is growing evidence that oxygen-derived free radicals(OFR's) play a role in the pathogenesis of pancreatic diseases, especially of acute pancreatitis. Many types of experimental ex vivo and in vitro pancreatitis can be inhibited by superoxide dismutase and catalse. (continue...)
Hyperamylasemia* ; Oxygen* ; Pancreatic Diseases ; Pancreatitis ; Superoxide Dismutase

No abstract available.
Animals ; Mice* ; Skin* ; Superoxide Dismutase* ; Superoxides*

No abstract available.
Gingiva* ; Periodontitis ; Protein Isoforms* ; Superoxide Dismutase* ; Superoxides*

Study on oxidant stress status in rat with carrageenan-induced inflammation and intervention’s ability with Artocarpus tonkinensis extract and the aqueous extract (unidentified scientific name), collected in Phu Tho. Results: carragenin 1% injection into sole of the foot of white mice that caused paw edema in mice after 4 hours. The edema status gained medium value of 118.98±15.94mg in sole of the foot. Mivce was preventively administrated by oral diclofenac. Flavonoid extract from Artocarpus tonkinensis leaves and the aqueous extract in studying doses had reduced clearly edema. There were significantly decreases in SOD activities of inflammation mice and increases of MDA level - an indicator of lipid superoxide reaction - in correlation with inflammation status of different mice groups. There was a positive correlation between edema level of mice groups and MDA levels
Plants, medicinal ; Superoxide Dismutase ; Mice ; Carrageenan ; Inflammation

To study the effects of different pH HEPES-KH reperfusate solution on immature myocardial protection, isolated perfused Langendorff model from immature rabbit hearts were developed formed. Control group (C) was perfused only with pH 7.4 HEPES-KH solution for 90 min. Ischemia/reperfusion group (group I/R) was perfused with pH 7.4 HEPES-KH solution before ischemia or after ischemia. Experimental group (group E), after ischemia, was perfused with pH 6.8, pH 7.1 and pH 7.4 HEPES-KH solutions for 5 min, 5 min, and 20 min, respectively. The left ventricular function recovery, MWC, LDH and CK leakage, MDA, ATP content, and SOD activity were determined. Our results showed that the left ventricular function recovery, ATP content and SOD activity in group E were higher than those of group I/R (P < 0.05). MWC, MDA content, LDH and CK leakage in group E were lower than those of group I/R (P < 0.05). These findings suggested that pH paradox might be one of important mechanisms for immature myocardial ischemia-reperfusion injury, and acidic perfusate, at the beginning of reperfusion, might attenuate pH paradox and ameliorate functional recovery in isolated perfused immature rabbit hearts.
Myocardium/metabolism ; Random Allocation ; Superoxide Dismutase/metabolism

This study was undertaken to know whether the UV-irradiation of the skin causes changes in the superoxide dismutase(SOD) activities. After shaving, the back skin of the rabbit was irradiated with UV light ranging from 280 to 320 nm of wavelengths from Burdick lamb (UV800) in doses of either 0.5, 1.0 or l.5 J/cm2. The skin was removed imrnediately after irradiation and the enzyme activity was assayed by the method of McCord ad Fridovich (xanthine-xanthie oxidase system), One unit of the SOD activity was defined as the amount of the enzyme required to inhibit the rate of reduction of cytochrome c by 50%. The protein content of the enzyme was determined by biuret method. The SOD activity of the skin irradiated with 1.0 J/cm was 7. 78 + 1.62 unit/mg protein(Mean+SD; n=10), significantly higher than that of the control(nonirradiated) group(5.62+1.57 unit/mg protein; n=l0). No significant changes were found in the skins irradiated with 1.5 and 1.5 J/cm. This finding indicates that UV irradiation is capablc of increasing the SOD activitiea in the rabbit skin, and suggests that increased superoxide formed by UV irradiatiun induces the increased SOD activies.
Biuret ; Cytochromes c ; Oxidoreductases ; Skin* ; Superoxide Dismutase* ; Superoxides* ; Ultraviolet Rays

No abstract available.
Catalase ; Erythrocytes* ; Glutathione Peroxidase ; Humans ; Infant, Newborn* ; Superoxide Dismutase

OBJECTIVE: To investigate the protective effects and potential mechanisms of tea polyphenols intervention on excess alcohol intake induced liver injury in rats. This study established the animal model of chronic liver injury rats induced by alcohol. Our results will provide experimental evidence for the effects of tea polyphenol on chronic alcoholic liver injury. METHODS: Alcohol-induced liver injury rat models were established, and the tea polyphenols intervention was performed in the meantime. After 8 weeks, rats were anesthetized, and visceral fat and liver samples were separated, weighted and stored. Visceral fat content was evaluated in fat/body weight ratio. Liver lipid accumulation was assessed by liver index and the result of Oil Red O staining. Hepatic superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, total antioxidant capacity assay (T-AOC) and glutathione peroxidase (GSH-Px) activity were detected. And fatty acid translocase (FAT/CD36) protein level in liver was detected. RESULTS: Compared with the control group rats, the fat/body weight ratio, SOD/MDA, T-AOC and GSH-Px activity of chronic liver injury rats were decreased significantly (<0.05,<0.01). Meanwhile the liver index, FAT/CD36 protein level and lipid deposition in liver of chronic liver injury rats were increased (<0.01). Compared with chronic liver injury rats, the tea polyphenols intervention increased fat/body weight ratio (<0.05), and significantly increased SOD/MDA, T-AOC and GSH-Px activity (<0.01). Meanwhile the tea polyphenols intervention reduced liver index (<0.01), FAT/CD36 protein level (<0.01) and lipid deposition in liver. CONCLUSIONS Tea polyphenols intervention can improve lipid deposition and oxidative stress in chronic alcoholic liver, which is concurrent with decreased FAT/CD36 protein expression on the hepatocyte membrane.
Animals ; Antioxidants ; Liver ; Malondialdehyde ; Polyphenols ; Rats ; Superoxide Dismutase ; Tea