Objective To observe the effects of ligustrazine intra-articular injection on cartilage degeneration in OA.To estimate and discuss the vistas of clinical application with ligustrazine intraarticular injection.(Methods)26 New Zealand white rabbits were randomly divided into 4 groups,2 rabbits in normal group,8 rabbits in model,control and experimental group,respectively.OA animal model was established in rabbits by the way of fixing right posterior knee joint with plaster cast in strecthing state in model,control and experimental group.(0.3mL) ligustrazine intra-articular injection was carried out once a week in experimental group.(0.3mL) dexamethasone in the same way was made in control group.At 6 week and 9 weeks later,optic and electron microscopic examinations were conducted to observe the pathological changes of articular cartilage of the knee of these animals.Results There was a significant difference in Mankin scale between experimental group and 3 other groups((P0.05)),and between these 2 groups the electro microscopic observation was similar.Conclusion Intra-articular injection of ligustrazine can alleviate degeneration and promote self-reparation of articular cartilage.Method of intra-articular injection of cortisocteroid has no reparation effect on OA cartilage(degeneration).

Objective To observe the clinical effects and complications of primary trigeminal neuralgia treatment with radiofrequency thermocoagulation on gasserian ganglion. Methods Under the guidance of C-arm or DSA and with Hartel method, we percutaneously punctured the oval foramen to gasserian ganglion and performed radiofrequency times. Results Pain was completed eliminated in 53 of the 56 patients, which was regarded as degree Ⅰ of clinical cure with the curativeness rate being 96.4%; 1 case was of degree Ⅱ; 1 case was of degree Ⅲ; 1 case had no effect. The rate of satisfactory effectiveness was 96.4% and the total rate of efficacy was 98.2%. No severe complications were observed. Conclusion Radiofrequency thermocoagulation is a safe and effective method to treat primary trigeminal neuralgia with few severe complications.

Objective To investigate the effect of radiofrequency ablation on serum tumor necrosis factor alpha-α(TNF-α),interferon gamma-γ(IFN-γ)and interleukin 17 (IL-17)levels in patients with lumbar disc herniation.Methods We studied 276 patients with lumbar disc herniation admitted to the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2015.The experimental group received radiofrequency thermocoagulation and target ablation decompression treatment.In the same period,133 healthy subjects were selected as control group.We collected the general information of the admitted patients and their serum before and after operation as well as serum of the control group.The changes of TNF-α,IFN-γand IL-17 levels were detected by ELISA method.Results The levels of serum TNF-α,IFN-γand IL-17 in the patients with lumbar disc herniation were significantly higher than those in the control group (P<0.05 ).Compared with those before operation,the serum levels of TNF-α,IFN-γand IL-17 were decreased significantly in the recovery phase after radiofrequency ablation (P<0.05).Conclusion Frequency thermal coagulation target ablation decompression treatment of lumbar disc herniation can not only improve pain symptoms but also reduce the systemic inflammatory reactions.Therefore,it deserves clinical application.

Objective To investigate the effect of continuous nursing based on transtheoretical model (TTM) on elderly patients with knee osteoarthitis (KOA). Methods A total of 120 elderly patients with KOA from January 2015 to December 2016 were selected and divided into observation group and control group by the random digits table method , with 60 cases in each. The observation group was given continuous nursing based on TTM, while the control group was given continuous nursing. The functions and symptoms of knee joint of the 2 groups were evaluated by Lysholm Knee Scale Scores (LKSS) and Lequesne's Indexes (LI) after 6 months of implementation and compared. The compliance of rehabilitation training, the distribution of different behavior stages and the quality of life were compared after 6 months of implementation. Results The score of LKSS of the observation group was (78.04±8.55) points, and that of the control group was (69.22 ± 7.90) points, and there was significant difference between the 2 groups (t=6.780, P<0.05). The LI of the observation group was (5.37±1.05) points, and the control group was (6.09 ± 1.60) points, and there was significant difference between the 2 groups (t =3.356, P<0.05). There were significant differences in the distributions of the compliance of rehabilitation training and different behavior stages between the 2 groups (Z=5.814, 6.910, P<0.05). The rate of completely compliance, the percentage of action and maintenance stages of the observation group was 85.00%(51/60), 53.33% (32/60), and the control group was 55.00% (33/60), 28.33% (17/60) , and there was a significant difference between the 2 groups (χ2=12.857, 7.761, P<0.05). The physical condition, symptom and other 5 life quality scores and the total score of the observation group was (26.37±3.08), (11.80±2.15), (18.66± 2.27), (14.98±2.52), (6.93±0.94), (78.69±10.36) points, and the control group was (24.22±3.32), (9.44± 1.29), (17.24±3.07), (14.06±2.07), (6.56±1.05), (71.62±12.15) points, and there was significant difference between the 2 groups (t =2.034-7.291, all P<0.05). Conclusions The application of continuous nursing based on TTM on elderly patients with KOA can significantly change the stages of healthy behavior, improve the patients' compliance of rehabilitation training and quality of life, improve the function and symptom of knee joint.

Objective To study the efficacy and safety of ultrasound-guided pulse radiofrequency(PRF)treatment of the saphenous nerve for knee osteoarthritis(KOA).Methods A total of 289 KOA patients were followed up from March 2021 to October 2023 and divided into PRF group(group A,n=142)and conservative treatment group(group B,n=147)according to different treatment methods.Pain degree(VAS),knee function(OKS),and sleep quality(AIS)of the two groups were recorded before treatment and at 1 week,1 month,3 months and 6 months after treatment;the occurrence of complications was recorded for comparison between the two groups.Results After treatment,VAS,OKS and AIS scores in both groups decreased compared with those before treatment(P＜0.001).In addition,the scores of group A showed a gradual downward trend 6 months after surgery,while the scores of group B showed an overall upward trend 6 months after surgery.The scores of VAS and OKS were significantly lower in group A than in group B from 1 week to 6 months after surgery(P＜0.001).The AIS score of group A was much lower than that of group B from 1 month to 6 months after surgery(P＜0.001).There was no significant difference in the incidence of complications between the two groups(P=0.236).Conclusion Ultrasound-guided PRF treatment of the saphenous nerve is better than conservative treatment because it can better reduce pain and improve knee joint mobility and sleep in patients with KOA.

Objective:To comprehensively evaluate the clinical efficacy and safety of pulse radiofrequency therapy for knee osteoarthritis (KOA) with cardiovascular disease (CVD).Methods:A total of 132 patients with knee osteoarthritis (KOA) and cardiovascular disease (CVD) admitted to the First Affiliated Hospital of Xi′an Jiaotong University from March 2022 to February 2024 were randomly divided into two groups using a random number table method. Group A (65 cases) received ultrasound-guided pulse radiofrequency treatment of the hidden nerve, while group B (67 cases) received oral etoposide tablets and intra-articular injection of sodium hyaluronate. Basic data such as age, gender, height, weight, body mass index (BMI), knee joint function grading (K-L grading), and distribution of cardiovascular disease types were recorded between the two groups. The degree of knee joint pain [Visual Analog Scale (VAS) score] and Knee Joint Function Score (OKS), Athens Insomnia Scale (AIS) scores and incidence of complications. were compared between the two groups at 1 week, 1 month, 3 months, and 6 months after treatment.Results:The VAS score of group A showed a slow decreasing trend from 1 week to 6 months after treatment. The VAS score of group B decreased to the lowest level one week after treatment and gradually increased within 6 months after treatment. The VAS scores of both groups improved after 1 week of treatment and at 1, 3, and 6 months of treatment compared to preoperative levels ( F=703.955, P<0.001), and the degree of postoperative pain improvement in the group A was better than that in the group B ( F=106.575, P<0.001). The OKS of both groups decreased significantly after 1 week of treatment and at 1, 3, and 6 months of treatment, and the time effect was statistically significant ( F=2 233.447, P<0.001). The OKS of the group A was lower than that of group B after 1 week of treatment and at 1, 3, and 6 months of treatment, and the difference was statistically significant ( F=141.214, P<0.001). The AIS scores improved significantly after 6 months of treatment compared to preoperative levels ( F=1 044.424, P<0.001), and the group A had better AIS scores than the group B at 1, 3, and 6 months of treatment, with statistically significant differences ( F=124.864, P<0.001). There was no statistically significant difference in postoperative complications between the two groups ( P>0.05). Conclusions:Ultrasound guided pulsed radiofrequency treatment of KOA with CVD can significantly alleviate postoperative pain, improve joint mobility and sleep quality, and is more effective than traditional conservative treatment of oral etoposide tablets combined with intra-articular injection of sodium hyaluronate.

[Objective] To compare the clinical efficacy of pulsed radiofrequency (PRF) in patients with acute herpes zoster neuralgia (AHN) and postherpetic neuralgia (PHN). [Methods] A retrospective analysis was made on 287 patients with thoracic herpes zoster related pain. The patients were divided into acute herpes zoster neuralgia group (group AHN, within 3 months) and PHN group (group PHN, over 3 months) according to the onset time of herpes zoster. Pain degree (VAS), sleep quality (AIS), anxiety and depression (GAD-7 and PHQ-9) at 1 week, 1 month, 3 months, 6 months and 12 months after the procedure were analyzed and compared between the two groups. [Results] The scores of VAS, AIS, GAD-7 and PHQ-9 significantly decreased in both groups after surgery (P<0.001). The four scores decreased more in AHN group than in PHN group from 1 to 12 months after surgery (P<0.001). After 12 months of follow-up, there were fewer cases of taking oral pregabalin and opioids in the former group than in the latter group (P=0.001). [Conclusion] PRF has a good therapeutic effect on herpes zoster related pain and is better than PHN in relieving pain, improving sleep and anxiety and depression in AHN, or can prevent PHN.