The concept of white matter dementia was first introduced by Filley in 1988.It was found following behavioral neurologica researches that patients with this type of dementia manifested the dysfunctions of sustained attention,memory retrievial,frontal lobe and visualspatial function.They also had psychiatric manifestations but language and extrapyramidal function remained normal.10 diseases of white matter disorders are listed for understanding the clinical characteristics of this type of dementia.

AIM: To investigate the efficacy and safety of liduofen in the treatment of patients with osteoarthritis of the knee joint. METHODS: A randomized, double-blind, parallel-controlled, multi-centre study was adapted to compare the efficacy and safety between liduofen and Olfen-75 in 136 patients. Patients were randomly assigned into two groups: liduofen group which was received 75 mg (diclofenac) Liduofen injection (n=69) once a day for seven days and Olfen group which was received 75 mg (diclofenac) Olfen-75 injection (n=67) once a day for seven days. RESULTS: After the treatment, similar improvements for rest pain, pain on exercise, swelling of joint, pressing pain of joint, knee joint bend extend function measured using a 10 cm visual analogue scale was performed in two groups. In Olfen-75 group, the rate of efficacy was 62.69% in the 3rd day, 95.76% in the 5th day and 97.88% in the 7th day. While in liduofen group, the rate of efficacy was 57.97% in the 3rd day, 93.87% in the 5th day and 96.94% in the 7th day. In liduofen and Olfen-75 groups, the progressive rates were 56.72% and 55.07%, respectively. The total improvement rates were 89.85% and 92.54% respectively (P＞0.05), and the rates of side effects were 0% and 1.49%, respectively (P＞0.05). CONCLUSION: Liduofen is an effective and safty drug inthe treatment of patients with osteoarthritis of the knee joint. There is no significant difference on efficacy and safety between the two groups using liduofen and Olfen-75.

Objective To explore and analyze the pathogenic bacteria distribution and its prognostic factors of pneumonia patients after chronic intracerebral hemorrhage. Methods 375 pneumonia patients after chronic intracerebral hemorrhage who were treated in the rehabilitation department of Qingdao Workers' Sanatorium of Shandong Provincial Federation of Trade Unions from July 2011 to July 2013 were chosen as the research objects. The clinical data of all the subjects were collected, and the pathogenic bacteria distribution and its prognostic factors were analyzed by SPSS 17.0 statistical package. Results Good prognosis rate of the pneumonia patients after chronic intracerebral hemorrhage was 85.60%, the bacterium was the main pathogenic bacteria, accounted for 42.51%. Multiariable logistic regression analysis showed that swallowing reflex disorder (OR=12.922,P<0.01) and the combination of respiratory system disease (OR=3.327,P<0.01) were risk factors for the prognosis of pneumonia patients after chronic intracerebral hemorrhage, and chest breathing training (OR=0.695,P<0.01) was the protection factor. Conclusion The prognosis of pneumonia patients after chronic intracerebral hemorrhage is tolerable. The gram-negative bacterium is the main pathogenic bacteria. The prognostic factors of pneumonia patients after chronic intracerebral hemorrhage is concerned with swallowing reflex obstacles, other combination of respiratory system diseases and chest breathing training.In the process of clinical medical, we should strengthen the chest breathing training guidance and improve the prognosis of patients, especially in high-risk groups.

At present,stroke has become one of the diseases seriously harming the human life and the quality of life with its high morbidity,disability,and mortality.Therefore,clinicians need to find more effective indicators to identify the clinical conditions and outcomes,and guide the treatment.Studies in recent years have suggested that the biological markers have important clinical value for guiding the treatment of stroke.

Objective To evaluate the effects of curcumin on matrix metalloproteinase-9 (MMP-9)/tissure inhibitor of metalloproteinase-1 (TIMP-1) balance during limb ischemia-reperfusion (I/R)-induced lung injury in rats.Methods Twenty-four adult male Sprague-Dawley rats,aged 6-8 months,weighing 250-300 g,were randomly divided into 3 groups (n =8 each) using a random number table:sham operation group (group S) ; group I/R; curcumin + I/R group (group C + I/R).Limb ischemia was induced by occlusion of bilateral femoral arteries for 2 h followed by reperfusion for 3 h in I/R and C + I/R groups.At 2 h before ischemia,curcumin 200 mg/kg was injected intraperitoneally in group C + I/R,while the equal volume of normal saline was given instead in the other groups.Arterial blood samples were taken at 3 h of reperfusion for blood gas analysis and PaO2 was recorded.The animals were then sacrificed and the lungs were removed immediately for determination of wet/dry lung weight (W/D) ratio,myeloperoxidase (MPO) activity and MMP-9 and TIMP-1 contents.The ratio of MMP-9/ TIMP-1 was calculated.Results Compared with group S,PaO2 was significantly decreased,and W/D ratio,MPO activity,MMP-9 content and the ratio of MMP-9/TIMP-1 were significantly increased (P ＜ 0.05),while no significant change was found in TIMP-1 content in group I/R (P ＞ 0.05).Compared with group I/R,PaO2 and TIMP-1 content were significantly increased,and W/D ratio,MPO activity,MMP-9 content and the ratio of MMP-9/TIMP-1 were significantly decreased in group C + I/R (P ＜ 0.05).Conclusion The mechanism by which curcumin attenuates lung injury induced by limb I/R is related to decreased MMP-9 content,elevated TIMP-1 content and regulated balance between MMP-9 and TIMP-1 in the lung tissues of rats.

ObjectiveTo study the clinical effect of sodium aescinate on the edema of limb tibial plate fracture.Methods69 patients with edema of limb of tibial plate fracture were randomly divided into two groups,treatment group(46 cases)and control group(23 cases).Both of them were transfused with 20％ mannitol(250ml,Bid ×7days).In addition,these patients in the treatment group were treated with sodium aescinate(30mg Qd × 7days).ResultsThe repercussive effect of the edema grade in the treatment group were obviously better than those in the control group(P ＜0.05 ).ConclusionSodium aescinate had a remarkable repercussive effect on the limb edema of tibial plate fracture.

The diagnosis and treatment of age-related macular degeneration (AMD) is an international hotspot of eye research.Successful clinical applications of anti-VEGF drugs promoted both basic research and clinical practice of AMD.A number of countries and professional societies have established clinical guidelines for AMD management,including the epidemiology,risk factors,diagnosis,classification,and treatment process.These AMD guidelines are mostly based on recently published results of clinical trials,provided good model of evidence based medicine.It is urgent and necessary to have our own guideline which is suitable for Chinese patients.Reviewing and learning existed guidelines will help us to improve the clinical practice of AMD in China.

Objective:To explore the relationship between the expression of EGFR and STAT3 in human la-ryngeal papilloma and its biological behavior. Method: Reverse transcription polymerasechain reaction(RT-PCR), immunohistochemical staining and Western blot were used to evaluate the mRNA and protein expression of EGFR and STAT3(p-STAT3) in 42 laryngeal papilloma tissues and 15 samples of normal laryngeal tissue, and the rela-tionship between the protein expression of them and clinicpathological parameters was also analysized. Result: The mRNA expression levels of EGFR and STAT3 in laryngeal papilloma tissue were significantly higher than that in normal laryngeal tissue(P<0.05,P<0.01). Protein positive expression of EGFR and p-STAT3 were also detected in a significantly greater proportion of laryngeal papilloma than normal laryngeal tissue by immunohistochemistry and western blot(P<0.01,P<0.05). There was relationship between EGFR and p-STAT3 overexpression in la-ryngeal papilloma(P<0.05). The expression p-STAT3 was correlated with the recurrence and canceration of la-ryngeal papilloma(P<0.05). Conclusion: The EGFR-STAT3 signal transduction pathway may be involved in the pathogenesis of laryngeal papilloma,, and the persistent activation of STAT3 gene plays an important role in the recurrence and canceration of laryngeal papilloma.

Objective To observe the clinical value of doppler ultrasound in evaluation of the treatment outcome of alcoholic liver disease.Methods 212 patients with alcoholic liver disease were selected.Ultrasound and liver function tests were applied before and after treatment,and temperance and medicines were applied for treating.The effects were used to observe the senlitivity of ultrasound applied in evaluation the treatment outcome of alcoholic liver disease.Results Of 212 cases,95 cases were diagnosed as alcoholic fatty liver disease by ultrasound before treatment,and the detection rate before treatment was 96.70％.51 cases were diagnosed as alcoholic hepatitis and 59 cases were alcoholic cirrhosis.After treatment,there were 37 cases had abnormal ultrasound images in 43 patients with alcoholic liver disease,and the detection rate was 86.04％.And 9 cases were diagnosed as alcoholic fatty liver disease by ultrasound,12 cases were diagnosed as alcoholic hepatitis and 16 cases were alcoholic cirrhosis.Conclusion It was noninvasive,cheap,convenient and repeated by using doppler ultrasound,and it was conducive to grasp the change of the condition of the patients for doctors.Ultrasound could be chosen as the preferred method for diagnosis of alcoholic liver disease.

Objective To investigate the therapeutic effect of flupentixol and melitracen tablets for irritable bowel syndrome (IBS).Methods Relevant concerned with the therapeutic effect of Flupentixol and melitracen tablets and routine medicine were reviewed by China national knowledge infrastructure.All reviewed literatures were accessed by Jadad quality scale.Statistic data was analysed by RevMan5.0 and Stata.Results Twelve articles of randomized controlled trial were collected.Among these study,there were 1384 patients,which divided into treatment group (n =704) and control group (n =680).The results of heterogeneity showed that x2 =25.48,P =0.008,I2 =57％.Therefore the random effects model was selected.The combined relative risk is 1.39 and the 95％ CI was 1.27-1.53.Conclusion Compared with traditional treatment,flupentixol and melitracen tablets can obviously improve the therapeutic effect of IBS.