Objective:To study and assess therapeutic effect of Fei Laoning in accessory treatment of pulmonary tuberculosis of retu treatment.Methods:67 cases of return treatment with positive tuberculomyces were randomly divided into a treatment group of 3 cases and a control group of 33 cases.They were all treated by the program,3Pa(H)L2VZ(TH)E(Ak)/6Pa(H)L2V,wit Feilaoning added to the treatment group for 3 months.Results:One,three and six months after treatment,the returning negativ rates for the bacterium in phlegm were 61.8%,94.1%,97.1%and 30.3%.75.8%,78.8%;the absorption rates of foci wer 73.5%,94.1%, 97.1% and 36.4%,75.8%,81.8% in the treatment group and the control group,respectively,with significan differences between the two groups(P

P53 gene (exon7～8) mutatins and p53 proteins and HPV 6，11，16，18-DNA were examined in 49 cervical carcinoma by immunohistochemistry, polymerase chain reaction (PCR) and single strand conformation polymorphism (SSCP) in order to investigate their role and mutual relation and clinical significance in the onco genesis of cervical carcinoma. The results showed that first, p53 proteins posit ive rate was 48.98％, and not outstandingly related to the differentiation and the invasive degree of cervical carcinoma(P＞0.05); the defects of P53 gene (exon7～8) were not found but P53 (exon7～8) mutations were detected in 7 of 49(14.29％) cervical carcinoma; then, HPV16-DNA positive rate was much higher than HPV6,11,18-DNA positive rate respectively(P＜0.001),and the different HPV-DNA was simultaneously tested in one cerv ical carcinoma; last, not all cases of P53 mutations had p53 proteins posi tive, but the cases of P53 mutations and p53 proteins negative certainly had HPV infections, and HPV positive cases were much more than its negative one in the cases of p53 proteins positive(P＜0.001). These results proved that the oncogenesis of cervical carcinoma is mainly associated with HPV16 infections, and second related to P53 (exon7～8) mutations. p53 proteins positive results from P53 mutations or/and HPV infections in cervical carc inoma.

BACKGROUND: Great concerns haven been given increasingly on inhibition of nutrient with antioxidation efficacy on lipid peroxidation and its effect on prevention of cardiac vascular disease.OBJECTIVE: To probe into the effects of plantain seed that acts on eliminating oxygenic free radical and antioxidation on lipid metabolism and antioxidation in rats.DESIGN: Randomized control experiment was designed.SETTING: Experimental Room of Pharmacology and Toxicology of New Drug in Hebei Province.PARTICIPANTS: The experiment was performed in Experimental Room of Pharmacology and Toxicology of New Drug in Hebe Province from January to December 2004, in which, 40 SD rats were employed, provided from Hebei Experimental Animal Center, of healthy grade I, mass weighted (210±22) g and of either sex. They were randomized into 5groups, named, blank control, positive control, low dosage experiment group, moderate dosage experiment group and high dosage experiment group, 8 rats in each one.METHODS: In blank control, the rats were bred everyday with basic forage that was tallied with AoAc animal nutrient criteria and they were free of drinking. In positive control, the rats were bred with high-lipid forage and free of drinking. In the groups of low, moderate and high dosages of plantain seed, the rats were bred with 2.5 g/kg, 5 g/kg and 15 g/kg plantain seed successively besides high-lipid forage and they were free of drinking. The weight was measured and the food intake was recorded every week. Fasting blood was collected to check total cholesterol in serum once every two weeks. The experiment was end in 12 weeks. Under anesthesia,the blood was collected from hypogastric aorta to check the level of serum blood lipid and the activities of superoxide dismutase (SOD) and catalase.After blood collection, the heart and liver were extracted immediately for management to measure SOD activity and content of lipid peroxide (LPO)in myocardial tissue and the activities of catalase and glutathione peroxidase in liver tissue.MAIN OUTCOME MEASURES: Level of blood lipid and activities of SOD and catalase in rats.RESULTS: Forty rats were employed and all entered result analysis. [1]Serum total cholesterol: It was lower significantly in high dosage group compared with positive control [(1.40±0.13, 1.83±0.13) mmol/L, P ＜ 0.05].[2] Serum SOD activity: It was lower remarkably in positive control compared with blank control [(174.29±10.33, 193.19±.7813) NU/mg, P ＜ 0.05].[3] LPO content in serum: It was higher significantly in positive control compared with blank control [(3.64±0.26, 2.91±0.50) mmol/mg, P ＜ 0.05]and it was lower significantly in moderate dosage group compared with positive control (3.13±0.26, 3.64±0.26, P ＜ 0.05). [4] Activity of catalase in liver tissue: It was lower remarkably in positive control compared with normal control (34.64±3.26, 44.72±2.67, P ＜ 0.05) and it was higher remarkably in moderate dosage group compared with positive control (44.84±3.79,34.96±3.64, P ＜ 0.05).CONCLUSION: Plantain seed reduces the levels of total cholesterol,triglycerin (TG) and LPO in serum and increases SOD activity. At the concentration of 15 g/kg, plantain seed acts most remarkably on eliminating oxygenic free radical and antioxidation and alleviates lipid metabolic disturbance.

Objective To study the effect of the PDCA management on safety management of venous transfusion by indwelling needles?.Method The measures included standardizing nurses manipulation,improving the management system related to venous transfusion,and regulating details management process for tube fixing and dressing and tube maintenance.Results The rates of unstandardized maintenance and obstruction of tubes after the enforcement of details management were significantly lower than those before its enforcement(P<0?05).Conclusions PDCA management is effective for standardizing nursing implementation and ensuring the safety of venous transfusion by indwelling needle?

Objective To assess the therapeutic effect of esomerphrazole in treating patients with gastroesophageal reflux disease (GRED) between Han and Inner Mongolia populations.Methods Those who underwent endoscopic examination and had reflux disease questionnaire (RDQ) >12 from March 2006 to March 2008 were selected. The patients were divided into Han group and Inner Mongolia group with 120 each. All patients were received esomerphrazole 20 mg daily for 6 weeks. The patients were evaluated by RDQ questionnaire at 2nd, 4th and 6th week, and were reexamined by gastroscopy at 6th week. Results After two weeks, effective rate of 50% was achieved in both groups, but it was higher in Han group than in Inner Mongolia group at 4th and 6th week. After 6 weeks, the curative rate of RE was higher in Han group than in Inner Mongolia group. Conclusion The different nations ancl habits result in the different efficacy of esomerphrazole, which may be improved by prolonging time of medication and changing habits.

0.1).Not all cases of p53 mutations were with p53 protein positive.Conclusion:p53 (exon 7 8) mutation is not a main factor for the structural abnormality of p53 protein in the oncogenesis of cervical cancer.

Objective: To investigate the influence of histamine content in nasal mucosa on blood flow. Methods: Sixty guinea pigs were randomly devided into control group and allergized group and guinea pigs were sacrificed before nasal challenge with allergen and immediately after nasal challenge, at 24, 48, 72 h. The content of histamine in nasal mucosa was examined. Nasal mucosa blood flow was examined in all guinea pigs before sacrifice. The data were analyzed using linear correlation and linear regression. Results: As compared with normal guinea pigs, the content of histamine and blood flow in nasal mucosa of allergic rhinitis guinea pigs were significantly increased before challengd with allergen( P

Objective: To investigate the effect of Plantago asiatica L. on antioxidation in rats. Methods: The antioxidative enzymes and LPO of serum, heart, and liver tissues were determined. Results: The activities of superoxide (SOD) in serum and heart were significantly lower than that of the control. The lipid peroxide (LPO) level in serum and heart was markedly higher than that of the control. Serum and liver catalase (CAT) activities in rats fed with high fat were decreased. Activities of liver glutathione peroxidase (GSH Px) in high fat rats were decreased significantly. The production of SOD activities in serum and liver and GSH Px in liver were increased significantly in rats maintained on Plantago asiatica L. supplemented diets, meanwhile serum and heart LPO were reduced. Conclusion: 15g/kg Plantago asiatica L. can increase the antioxidation against lipid peroxide in hyperlipidemic rats.

Objective To evaluate the value of magnetic source imaging(MSI) in localizing the epileptic foci of patients with histologically proved grey matter heterotopia(GMH) and seizure. Methods MSI examinations were performed on 8 patients with GMH and seizure. The location of the epileptic foci defined by MSI was compared with the results of the ECoG. After imaging examinations, all patients received operation with 13-48 months follow up to observe the effectiveness of the operation. Results Among the 8 patients, 1 had hippocampal sclerosis,2 had focal cortical dysplasiaof type Ⅰ B and 1 had focal cortical dysplasia of type Ⅱ B. MRI showed normal findings in 2 cases, subcortical heterotopia in 4 cases, and nodulor heterotopia in 2 cases with one having schizencephaly. The epileptic foci defined by MSI were at right temporal lobe in 2 cases, left frontal lobe in 2 cases, biparietal lobe in1 case, left parietal lobe in 1 case, left temporal lobe in 1 case, and left frontal-parietal lobe in 1 case. The epileptic foci defined by MSI were completely overlaid with area of GMH in 4 cases, closely behind the area of GMH in case, and partly overlaid with area of GMH in 1 cases with size larger than that of the latter. One patient showed two epileptic foci with one located within the area of GMH and the other one 2 centimeters anterior to the area of GMH.One case's epileptic focus located 2 centimeters posteolateral to the area of GMH . The locations of the epileptic foci defined by MSI showed no difference with those defined by ECoG in all patients. According to Engel classification of treatment effect of epilepsy, 6 patients achieved Engle class Ⅰ ( seizure free after operation ), and 2 patients Engel class Ⅳ ( no changes in the frequcenty of occurrence of seizures before and after operation ). Conclusion MSI can noninvasively and precisely localize the epileptic foci before operation in patients with GMH and seizure.

Objective To assess the value of magnetic source imaging (MSI) in localizing the linguistic center of auditory function of epileptic patients before operation. Methods Epileptic focus and the linguistic center of auditory function in 24 patients were localized with MSI before operation. And the relationship between epileptic focus and auditory language area was observed. Results The linguistic center of auditory function was localized in left temporal lobe in 14 patients, in right temporal lobe in 5 patients and in bilaterial temporal lobe in 5 patients. Epileptic focus was localized in left temporal lobe in 14 patients, in left temporal lobe and left parietal lobe in 1 patient, in right temporal lobe in 4 patients, in right temporal lobe and parietal lobe in 1 patient, in left frontal lobe and left temporal lobe in 1 patient, in right frontal lobe, right temporal lobe and parietal lobe in 1 patient, and in bilaterial temporal lobe in 2 patients. Epileptic focus was superimposed with the linguistic center of auditory function in 10 patients, while was not superimposed with the linguistic center of auditory function in 10 patients. The epileptic focus was localized in front of the linguistic center of auditory function in 3 patients, in behind of the linguistic center of auditory function in 1 patient. The lesion of the patient suffered from dysembryoplastic neuroepithelial tumor was not excised completely because the epileptic focus was superimposed with the linguistic center of auditory function, and the patient appeared language functional disturbance after operation in short period, remaining auditory hallucination occasionally after operation. Conclusion Epileptic focus and the linguistic center of auditory function can be localized accurately and the relationship between them can be observed clearly with MSI. MSI is useful to reduce the occurrence of language disturbance after operation.