OBJECTIVE: To investigate the retinal toxicity of different doses of moxifloxacin after intravitreal injection into rabbit eyes. METHODS: Eight male rabbits were divided into four groups; 2 rabbits each were injected intravitreally with moxifloxacin 48 ug, 240 ug, 480 ug, and normal saline solution. Ocular toxicity was assessed at day 3 and day 7 by slit-lamp biomicroscopy, ophthalmoscopy, and histology. RESULTS: All eyes showed no abnormalities on histologic evaluation. No relevant complications were found during slit-lamp biomicroscopy and indirect ophthalmoscopy. CONCLUSION: Intravitreal injection of 480 ug or less of moxifloxacin did not produce retinal toxicity histologically in rabbit eyes.
Animal ; MOXIFLOXACIN ; ENDOPHTHALMITIS ; INTRAVITREAL INJECTIONS

Purpose: To study the use of low temp ophthalmic cautery tip in performing continuous curvilinear capsulorhexis and the effect of heat produced by cautery on the corneal endothelium Materials and Methods: The tip of an ordinary low temp ophthalmic cautery was improvised with the use of stylet of a Simcoe I&A, fashioned like a Sinskey IOL manipulator. 20 rabbits were used in this experiment -10 right eyes served as cases and 10 left eyes as controls. In the experimental eyes, viscoelastic was injected prior to a 7mm capsulorhexis; in the control eyes, no capsulorhexis was done. The cornea of both experimental and control were removed in toto and submitted for histopathologic studies Results: A complete capsulorhexis was performed in all 10 experimental eyes. The anterior capsular flap adheres to the advancing cautery tip; continuous and circular capsulorhexis was observed. There was no significant difference observed between the experimental and control groups regarding endothelial cell loss Conclusion: The modified low temp ophthalmic cautery tip produced a complete capsulorhexis, with no effect on the corneal endothelium.
Human ; Aged ; Middle Aged ; PHACOEMULSIFICATION ; CAPSULORHEXIS ; CRYSTALLINE LENSCAPSULE ; CAUTERY